Treatment of Posttraumatic Stress Disorder: A State-of-the-art Review

Current Neuropharmacology, Год журнала: 2023, Номер 22(4), С. 557 - 635

Опубликована: Май 3, 2023

Abstract: This narrative state-of-the-art review paper describes the progress in understanding and treatment of Posttraumatic Stress Disorder (PTSD). Over last four decades, scientific landscape has matured, with many interdisciplinary contributions to its diagnosis, etiology, epidemiology. Advances genetics, neurobiology, stress pathophysiology, brain imaging have made it apparent that chronic PTSD is a systemic disorder high allostatic load. The current state includes wide variety pharmacological psychotherapeutic approaches, which are evidence-based. However, myriad challenges inherent disorder, such as individual barriers good outcome, comorbidity, emotional dysregulation, suicidality, dissociation, substance use, trauma-related guilt shame, often render response suboptimal. These discussed drivers for emerging novel including early interventions Golden Hours, interventions, medication augmentation use psychedelics, well targeting nervous system. All this aims improve symptom relief clinical outcomes. Finally, phase orientation recognized tool strategize position step progression pathophysiology. Revisions guidelines systems care will be needed incorporate innovative treatments evidence emerges they become mainstream. generation well-positioned address devastating disabling impact traumatic events through holistic, cutting-edge efforts research.

Язык: Английский

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Burnout and post-traumatic stress disorder symptoms among medical staff two years after the COVID-19 pandemic in Wuhan, China: Social support and resilience as mediators

Journal of Affective Disorders, Год журнала: 2022, Номер 321, С. 126 - 133

Опубликована: Окт. 21, 2022

Язык: Английский

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COVID-19 and mental health services in Sub-Saharan Africa: A critical literature review

Comprehensive Psychiatry, Год журнала: 2024, Номер 131, С. 152465 - 152465

Опубликована: Фев. 17, 2024

The COVID-19 pandemic has wrought a profound impact on mental health in Sub- Saharan Africa, exacerbating existing disparities and rendering individuals undergoing treatment particularly susceptible. This comprehensive critical review delves into the scope, nature, extent of services while concurrently elucidating pivotal lessons exemplary practices learnt from periods lockdown.

Язык: Английский

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Astrocyte-derived lactate in stress disorders

Neurobiology of Disease, Год журнала: 2024, Номер unknown, С. 106417 - 106417

Опубликована: Янв. 1, 2024

Stress disorders are psychiatric arising following stressful or traumatic events. They could deleteriously affect an individual's health because they often co-occur with mental illnesses. Considerable attention has been focused on neurons when considering the neurobiology of stress disorders. However, like other conditions, recent studies have highlighted importance astrocytes in pathophysiology stress-related In addition to their structural and homeostatic support role, actively serve several functions regulating synaptic transmission plasticity, protecting from toxic compounds, providing metabolic for neurons. The astrocyte-neuron lactate shuttle model sets forth supply under intense activity. Lactate also plays a role as signaling molecule recently studied regarding its antidepressant This review discusses involvement brain energy metabolism further reflects emerging

Язык: Английский

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Trends and factors influencing the mental health of college students in the post-pandemic: four consecutive cross-sectional surveys

Frontiers in Psychology, Год журнала: 2024, Номер 15

Опубликована: Июль 17, 2024

The long-term impact of COVID-19 on the mental health and well-being college students, specifically trends over time after full removal restrictions, has not been well-studied.

Язык: Английский

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Mental health and insomnia problems in healthcare workers after the COVID-19 pandemic: A multicenter cross-sectional study

World Journal of Psychiatry, Год журнала: 2024, Номер 14(5), С. 704 - 714

Опубликована: Май 15, 2024

BACKGROUND Healthcare workers (HCWs) are at increased risk of contracting coronavirus disease 2019 (COVID-19) as well worsening mental health problems and insomnia. These can persist for a long period, even after the pandemic. However, less is known about this topic. AIM To analyze health, insomnia problems, their influencing factors in HCWs COVID-19 METHODS This multicenter cross-sectional, hospital-based study was conducted from June 1st, 2023 to 30th, 2023, which half-year end emergency. Region-stratified population-based cluster sampling applied provincial level Chinese HCWs. Symptoms such anxiety, depression, were evaluated by Generalized Anxiety Disorder-7, Patient Health Questionnaire-9, Insomnia Severity Index. Factors symptoms identified multivariable logistic regression. RESULTS A total 2000 participants invited, response rate 70.6%. 1412 [618 (43.8%) doctors, 583 (41.3%) nurses 211 (14.9%) nonfrontline], 254 (18.0%), 231 (16.4%), 289 (20.5%) had insomnia, respectively; severe found 58 (4.1%), 49 (3.5%), 111 (7.9%) participants. Nurses, female sex, hospitalization symptoms; moreover, death family or friends factor symptoms. During outbreak, most [1086 (76.9%)] participating received psychological interventions, while nearly all [994 (70.4%)] them public education. Only 102 (7.2%) individual counseling COVID-19. CONCLUSION Although sleep relieved pandemic, they still faced challenges greater risks than did general population. Identifying would help providing targeted interventions. In addition, although major proportion have education, interventions insufficient.

Язык: Английский

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The Hospitalized COVID-19 Subjects and Post-traumatic Stress Disorder

Опубликована: Янв. 1, 2025

Язык: Английский

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Prevalence and influencing factors of occupational burnout among healthcare workers in the Chinese mainland during the late 2022 Omicron COVID-19 outbreak: a multicenter cross-sectional study

BMC Public Health, Год журнала: 2025, Номер 25(1)

Опубликована: Янв. 15, 2025

China witnessed an Omicron COVID-19 outbreak at the end of 2022. During this period, medical crowding and enormous pressure on healthcare systems occurred, which might result in occurrence occupational burnout among workers (HCWs). This study aims to investigate prevalence associated mental conditions, such as depressive symptoms, anxiety, PTSD perceived social support, resilience, mindfulness HCWs Chinese mainland during outbreak, explore potential risk protective factors influencing HCWs. A multicenter cross-sectional was conducted working from January 5 February 9, 2023. total 6552 participants were recruited by convenience sampling. Data collected demographic characteristics, burnout, PTSD, online questionnaires. Descriptive analyses performed describe participants' characteristics. Univariate-Multivariate used determine burnout. The results showed that disorders, 44.56%, 70.75%, 47.87%, 37.49%, respectively. Older age, female gender, higher income, more doses vaccine, a level mindfulness, support Working nurses, department currently taking charge treatment patients, high contracting due work, work intensity, anxiety symptoms Tailored interventions should be implemented alleviate disorders

Язык: Английский

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The status and influencing factors of death anxiety among Chinese college students under the COVID-19 pandemic: a cross-sectional study

BMC Public Health, Год журнала: 2025, Номер 25(1)

Опубликована: Янв. 22, 2025

To comprehend the current state of death anxiety among Chinese college students during COVID-19 pandemic, analyze its influencing factors, and provide recommendations for mitigating these students. From March to May 2023, utilizing a cluster sampling method, from three universities in Changzhou, Jiangsu, were selected as research participants. The investigation employed general information questionnaire, PTSD Checklist DSM-5 (PCL-5), Version Templer-Death Anxiety Scale (CT-DAS), brief version Big Five Inventory (BFI-10). Multivariate linear regression analysis was performed examine factors pandemic. total average score this study 44.35 ± 8.21. There positive correlation between scores both symptoms neuroticism (r = 0.134, 0.255, P < 0.01), negative extraversion, agreeableness, conscientiousness, age (r=-0.135, -0.049, -0.172, -0.093, all 0.01). indicated that gender, age, place origin, infection, scores, neuroticism, conscientiousness significant (all 0.05). Death pandemic is relatively high associated with personality traits. Appropriate intervention strategies can be formulated based on factors.

Язык: Английский

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Fear of COVID-19, traumatic growth, and traumatic stress symptoms: the mediating role of basic psychological needs

Frontiers in Psychology, Год журнала: 2025, Номер 15

Опубликована: Янв. 23, 2025

Although COVID-19 brought many negative psychological consequences, people also experienced growth. The present study investigated why this happened and hypothesized that self-determination theory’s (SDT’s) basic needs (BPNs) may play a role in explanation. Based on SDT, cross-sectional both the satisfaction frustration of BPNs mediated associations between fear COVID-19, post-traumatic growth (PTG), stress (PTS) symptoms. A sample 391 Peruvian adults (70.6% women; M age = 35.04, range 18 84) responded to several valid reliable questionnaires: Fear Scale (FCV.19S); Basic Psychological Needs Satisfaction Frustration (BPNSFS); Impact Event Scale-Revised (IES-R); Post-Traumatic Growth Inventory (PTGI). results showed need association PTG, positive PTG. In addition, direct effect was found from toward PTS importance considering SDT’s explaining PTG after experiencing COVID-19.

Язык: Английский

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