The anti-cancer effectiveness of some heterocyclic compounds containing sulfur atom

Results in Chemistry, Год журнала: 2025, Номер unknown, С. 102182 - 102182

Опубликована: Март 1, 2025

Язык: Английский

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Green Biocatalyst for Ultrasound-Assisted Thiazole Derivatives: Synthesis, Antibacterial Evaluation, and Docking Analysis

ACS Omega, Год журнала: 2024, Номер 9(12), С. 13666 - 13679

Опубликована: Март 12, 2024

The catalytic activity of chitosan (Cs) and grafted Cs led to the preparation terephthalohydrazide Schiff's base hydrogel (TCsSB), which was then investigated as an eco-friendly biocatalyst for synthesizing novel thiazole derivatives. TCsSB exhibited greater surface area higher thermal stability compared Cs, making it a promising biocatalyst. We synthesized two series thiazoles via reaction 2-(2-oxo-1,2-diphenylethylidene) hydrazine-1-carbothioamide with various hydrazonoyl chlorides 2-bromo-1-arylethan-1-ones, employing ultrasonic irradiation using catalyst. A comparative study between revealed yields than TCsSB. methodology offered advantages such mild conditions, quick times, high yields. could be reused multiple times without significant loss potency. chemical structures newly compounds were verified through IR,

Язык: Английский

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Environmental Fate, Ecotoxicity, and Remediation of Heterocyclic Pharmaceuticals as Emerging Contaminants: A Review of Long-Term Risks and Impacts

Organics, Год журнала: 2025, Номер 6(1), С. 1 - 1

Опубликована: Янв. 2, 2025

Heterocyclic pharmaceuticals are emerging contaminants due to their toxic, carcinogenic nature and detrimental impact on the natural ecosystem. These compounds pose a significant environmental concern given widespread use in medical therapy, constituting over 90% of new medications. Their unique chemical structure contributes persistence various matrices, necessitating urgent measures mitigate risks. This review comprehensively examines sources, fate, toxicity, long-term risks associated with heterocyclic pharmaceuticals, proposing potential remediation strategies. The article commences an overview diverse types applications, focusing containing heteroatoms such as nitrogen, oxygen, sulfur. Subsequently, it explores sources pathways through which these pollutants enter environment, including wastewater discharge, agricultural runoff, improper disposal, resistance biodegradation, bioaccumulation. toxic effects consequences exposure then discussed, encompassing neurotoxicity, genotoxicity, mutagenesis, cardiovascular metabolic carcinogenicity, teratogenesis. Additionally, this summarizes strategies treatment solutions aimed at reducing compounds, drawing insights from literature. research concludes by identifying critical areas for future research, emphasizing need more effective address growing posed contaminants.

Язык: Английский

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In-silico studies of 3-tert-butyl-7-[2-phenyl ethenyl]-4H-[1,3,4]thiadiazolo[2,3-c][1,2,4] triazin-4-one as a Potential SARS-CoV-2 Inhibitor: Insights from an experimental and computational approach

Journal of Molecular Structure, Год журнала: 2025, Номер 1330, С. 141356 - 141356

Опубликована: Фев. 21, 2025

Язык: Английский

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Transition metal-catalyzed cross-coupling reactions of N-aryl-2-aminopyridines

RSC Advances, Год журнала: 2025, Номер 15(2), С. 1134 - 1151

Опубликована: Янв. 1, 2025

Due to the presence of pyridyl directing group, N-aryl-2-aminopyridines can quickly form stable complexes with metals, leading cyclization and functionalization reactions. A large number N-heterocycles nitrogen-based molecules be easily constructed via this direct atom-economical cross-coupling strategy. In review, we have highlighted transformations in various transition metal catalysts, such as palladium, rhodium, iridium, ruthenium, cobalt copper.

Язык: Английский

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Prediction and Evaluation of Pyrimidinones Derivatives: DFT Analysis, Corrosion Inhibition, and Bioactivity Studies

Results in Surfaces and Interfaces, Год журнала: 2025, Номер unknown, С. 100448 - 100448

Опубликована: Фев. 1, 2025

Язык: Английский

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Synthesis and biological evaluation of coumarin appended thiazole hybrid heterocycles: Antibacterial and antifungal study

Journal of Molecular Structure, Год журнала: 2023, Номер 1293, С. 136229 - 136229

Опубликована: Июль 17, 2023

Язык: Английский

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Decoding the interaction of an imidazo-pyrimidine derivative with serum proteins: Spectroscopic, computational and structure-activity relationship analysis

Biophysical Chemistry, Год журнала: 2025, Номер 322, С. 107435 - 107435

Опубликована: Март 14, 2025

Язык: Английский

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Isatin-semicarbazone linked acetamide 1,2,3-triazole hybrids: Synthesis, antimicrobial evaluation and docking simulations

Journal of Molecular Structure, Год журнала: 2023, Номер 1287, С. 135660 - 135660

Опубликована: Апрель 25, 2023

Язык: Английский

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An Updated Overview on the Synthesis and Anticancer Evaluation of Quinazoline Derivatives

ChemistrySelect, Год журнала: 2023, Номер 8(30)

Опубликована: Авг. 10, 2023

Abstract Cancer, a leading global cause of death, necessitates the exploration safer and more effective anticancer drugs due to adverse side effects associated with current cytotoxic treatments. Quinazoline its derivatives have emerged as promising class demonstrated efficacy against diverse tumor types. In light these advancements, this comprehensive review aims outline recent developments in utilization quinazoline agents. Additionally, article offers valuable insights into potential for novel serve future drugs. By delving structure‐activity relationship study, equips researchers thorough understanding necessary designing substantial number impactful compounds, which hold great treatment various life‐threatening disorders.

Язык: Английский

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