Bioorganic Chemistry, Год журнала: 2025, Номер 158, С. 108319 - 108319
Опубликована: Фев. 27, 2025
Язык: Английский
Bioorganic Chemistry, Год журнала: 2025, Номер 158, С. 108319 - 108319
Опубликована: Фев. 27, 2025
Язык: Английский
Results in Chemistry, Год журнала: 2025, Номер unknown, С. 102182 - 102182
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
2ACS Omega, Год журнала: 2024, Номер 9(12), С. 13666 - 13679
Опубликована: Март 12, 2024
The catalytic activity of chitosan (Cs) and grafted Cs led to the preparation terephthalohydrazide Schiff's base hydrogel (TCsSB), which was then investigated as an eco-friendly biocatalyst for synthesizing novel thiazole derivatives. TCsSB exhibited greater surface area higher thermal stability compared Cs, making it a promising biocatalyst. We synthesized two series thiazoles via reaction 2-(2-oxo-1,2-diphenylethylidene) hydrazine-1-carbothioamide with various hydrazonoyl chlorides 2-bromo-1-arylethan-1-ones, employing ultrasonic irradiation using catalyst. A comparative study between revealed yields than TCsSB. methodology offered advantages such mild conditions, quick times, high yields. could be reused multiple times without significant loss potency. chemical structures newly compounds were verified through IR,
Язык: Английский
Процитировано
10Organics, Год журнала: 2025, Номер 6(1), С. 1 - 1
Опубликована: Янв. 2, 2025
Heterocyclic pharmaceuticals are emerging contaminants due to their toxic, carcinogenic nature and detrimental impact on the natural ecosystem. These compounds pose a significant environmental concern given widespread use in medical therapy, constituting over 90% of new medications. Their unique chemical structure contributes persistence various matrices, necessitating urgent measures mitigate risks. This review comprehensively examines sources, fate, toxicity, long-term risks associated with heterocyclic pharmaceuticals, proposing potential remediation strategies. The article commences an overview diverse types applications, focusing containing heteroatoms such as nitrogen, oxygen, sulfur. Subsequently, it explores sources pathways through which these pollutants enter environment, including wastewater discharge, agricultural runoff, improper disposal, resistance biodegradation, bioaccumulation. toxic effects consequences exposure then discussed, encompassing neurotoxicity, genotoxicity, mutagenesis, cardiovascular metabolic carcinogenicity, teratogenesis. Additionally, this summarizes strategies treatment solutions aimed at reducing compounds, drawing insights from literature. research concludes by identifying critical areas for future research, emphasizing need more effective address growing posed contaminants.
Язык: Английский
Процитировано
2Journal of Molecular Structure, Год журнала: 2025, Номер 1330, С. 141356 - 141356
Опубликована: Фев. 21, 2025
Язык: Английский
Процитировано
2RSC Advances, Год журнала: 2025, Номер 15(2), С. 1134 - 1151
Опубликована: Янв. 1, 2025
Due to the presence of pyridyl directing group, N-aryl-2-aminopyridines can quickly form stable complexes with metals, leading cyclization and functionalization reactions. A large number N-heterocycles nitrogen-based molecules be easily constructed via this direct atom-economical cross-coupling strategy. In review, we have highlighted transformations in various transition metal catalysts, such as palladium, rhodium, iridium, ruthenium, cobalt copper.
Язык: Английский
Процитировано
1Results in Surfaces and Interfaces, Год журнала: 2025, Номер unknown, С. 100448 - 100448
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
1Journal of Molecular Structure, Год журнала: 2023, Номер 1293, С. 136229 - 136229
Опубликована: Июль 17, 2023
Язык: Английский
Процитировано
23Biophysical Chemistry, Год журнала: 2025, Номер 322, С. 107435 - 107435
Опубликована: Март 14, 2025
Язык: Английский
Процитировано
1Journal of Molecular Structure, Год журнала: 2023, Номер 1287, С. 135660 - 135660
Опубликована: Апрель 25, 2023
Язык: Английский
Процитировано
11ChemistrySelect, Год журнала: 2023, Номер 8(30)
Опубликована: Авг. 10, 2023
Abstract Cancer, a leading global cause of death, necessitates the exploration safer and more effective anticancer drugs due to adverse side effects associated with current cytotoxic treatments. Quinazoline its derivatives have emerged as promising class demonstrated efficacy against diverse tumor types. In light these advancements, this comprehensive review aims outline recent developments in utilization quinazoline agents. Additionally, article offers valuable insights into potential for novel serve future drugs. By delving structure‐activity relationship study, equips researchers thorough understanding necessary designing substantial number impactful compounds, which hold great treatment various life‐threatening disorders.
Язык: Английский
Процитировано
10