Synthesis and biological evaluation of coumarin appended thiazole hybrid heterocycles: Antibacterial and antifungal study

Journal of Molecular Structure, Journal Year: 2023, Volume and Issue: 1293, P. 136229 - 136229

Published: July 17, 2023

Language: Английский

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Green Biocatalyst for Ultrasound-Assisted Thiazole Derivatives: Synthesis, Antibacterial Evaluation, and Docking Analysis

ACS Omega, Journal Year: 2024, Volume and Issue: 9(12), P. 13666 - 13679

Published: March 12, 2024

The catalytic activity of chitosan (Cs) and grafted Cs led to the preparation terephthalohydrazide Schiff's base hydrogel (TCsSB), which was then investigated as an eco-friendly biocatalyst for synthesizing novel thiazole derivatives. TCsSB exhibited greater surface area higher thermal stability compared Cs, making it a promising biocatalyst. We synthesized two series thiazoles via reaction 2-(2-oxo-1,2-diphenylethylidene) hydrazine-1-carbothioamide with various hydrazonoyl chlorides 2-bromo-1-arylethan-1-ones, employing ultrasonic irradiation using catalyst. A comparative study between revealed yields than TCsSB. methodology offered advantages such mild conditions, quick times, high yields. could be reused multiple times without significant loss potency. chemical structures newly compounds were verified through IR,

Language: Английский

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Environmental Fate, Ecotoxicity, and Remediation of Heterocyclic Pharmaceuticals as Emerging Contaminants: A Review of Long-Term Risks and Impacts

Organics, Journal Year: 2025, Volume and Issue: 6(1), P. 1 - 1

Published: Jan. 2, 2025

Heterocyclic pharmaceuticals are emerging contaminants due to their toxic, carcinogenic nature and detrimental impact on the natural ecosystem. These compounds pose a significant environmental concern given widespread use in medical therapy, constituting over 90% of new medications. Their unique chemical structure contributes persistence various matrices, necessitating urgent measures mitigate risks. This review comprehensively examines sources, fate, toxicity, long-term risks associated with heterocyclic pharmaceuticals, proposing potential remediation strategies. The article commences an overview diverse types applications, focusing containing heteroatoms such as nitrogen, oxygen, sulfur. Subsequently, it explores sources pathways through which these pollutants enter environment, including wastewater discharge, agricultural runoff, improper disposal, resistance biodegradation, bioaccumulation. toxic effects consequences exposure then discussed, encompassing neurotoxicity, genotoxicity, mutagenesis, cardiovascular metabolic carcinogenicity, teratogenesis. Additionally, this summarizes strategies treatment solutions aimed at reducing compounds, drawing insights from literature. research concludes by identifying critical areas for future research, emphasizing need more effective address growing posed contaminants.

Language: Английский

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Transition metal-catalyzed cross-coupling reactions of N-aryl-2-aminopyridines

RSC Advances, Journal Year: 2025, Volume and Issue: 15(2), P. 1134 - 1151

Published: Jan. 1, 2025

Due to the presence of pyridyl directing group, N-aryl-2-aminopyridines can quickly form stable complexes with metals, leading cyclization and functionalization reactions. A large number N-heterocycles nitrogen-based molecules be easily constructed via this direct atom-economical cross-coupling strategy. In review, we have highlighted transformations in various transition metal catalysts, such as palladium, rhodium, iridium, ruthenium, cobalt copper.

Language: Английский

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Prediction and Evaluation of Pyrimidinones Derivatives: DFT Analysis, Corrosion Inhibition, and Bioactivity Studies

Results in Surfaces and Interfaces, Journal Year: 2025, Volume and Issue: unknown, P. 100448 - 100448

Published: Feb. 1, 2025

Language: Английский

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In-silico studies of 3-tert-butyl-7-[2-phenyl ethenyl]-4H-[1,3,4]thiadiazolo[2,3-c][1,2,4] triazin-4-one as a Potential SARS-CoV-2 Inhibitor: Insights from an experimental and computational approach

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: 1330, P. 141356 - 141356

Published: Feb. 21, 2025

Language: Английский

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Isatin-semicarbazone linked acetamide 1,2,3-triazole hybrids: Synthesis, antimicrobial evaluation and docking simulations

Journal of Molecular Structure, Journal Year: 2023, Volume and Issue: 1287, P. 135660 - 135660

Published: April 25, 2023

Language: Английский

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Therapeutic Potential of Pyrazole Containing Compounds: an Updated Review

Pharmaceutical Chemistry Journal, Journal Year: 2024, Volume and Issue: 58(2), P. 252 - 267

Published: May 1, 2024

Language: Английский

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Conventional and microwave-assisted synthesis, antimicrobial and antioxidant activity evaluation with in silico studies of carbazole-thiazole-Schiff base hybrids

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1321, P. 139861 - 139861

Published: Aug. 31, 2024

Language: Английский

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Synthesis and Evaluation of Biologically Active Compounds from Heterocycles Class

Molecules, Journal Year: 2025, Volume and Issue: 30(2), P. 394 - 394

Published: Jan. 18, 2025

Heterocyclic compounds represent one of the most important classes natural and synthetic compounds, playing essential roles in various fields, including medicinal chemistry [...]

Language: Английский

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