Therapeutic Potential of Pyrazole Containing Compounds: an Updated Review

Pharmaceutical Chemistry Journal, Год журнала: 2024, Номер 58(2), С. 252 - 267

Опубликована: Май 1, 2024

Язык: Английский

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Conventional and microwave-assisted synthesis, antimicrobial and antioxidant activity evaluation with in silico studies of carbazole-thiazole-Schiff base hybrids

Journal of Molecular Structure, Год журнала: 2024, Номер 1321, С. 139861 - 139861

Опубликована: Авг. 31, 2024

Язык: Английский

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New 1,2,3-triazole-quinazolinone skeleton as potential cholinesterase and α-amylase inhibitors: In vitro and in silico studies

Journal of Molecular Liquids, Год журнала: 2025, Номер 424, С. 126986 - 126986

Опубликована: Янв. 22, 2025

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Heterocyclic compounds in targeted treatment of hepatocellular Carcinoma: Mechanistic Insights and clinical Implications

Inorganic Chemistry Communications, Год журнала: 2025, Номер unknown, С. 114704 - 114704

Опубликована: Май 1, 2025

Язык: Английский

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Simple, Effective and Green Synthesis of N-Heterocycles Using g- C3N4 Nanosheets as Photocatalyst Under Visible Light Irradiation

Catalysis Letters, Год журнала: 2025, Номер 155(7)

Опубликована: Май 26, 2025

Язык: Английский

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Synthesis, Identification and Preliminary Pharmacological Evaluation of New Hydrazone and 1, 3, 4-oxadiazole Derivatives of Ketorolac

Iraqi Journal of Pharmaceutical Sciences ( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512), Год журнала: 2024, Номер 33(1), С. 113 - 122

Опубликована: Март 28, 2024

New series of hydrazones (3a–b) and 1, 3, 4-oxadiazole S-alkylated derivatives (5a–b) ketorolac (NSAID) were synthesized their structures identified by using ATR-FT-IR ¹HNMR spectroscopic analytical techniques. The compounds evaluated in vitro for antimicrobial activity against Gram-positive bacteria (Staphylococcus aureus), Gram-negative (Escherichia coli), fungal species (Candida albicans). After the approval ethical committee college pharmacy, University Baghdad, In vivo screening anti-inflammatory was done albino rats as an animal model that subjected to white egg-induced acute inflammation. Results have shown target successfully synthesized, it discovered they mild moderate E.Coil S.aureus while no effect has on C.albicans. studies showed effective lowering paw edema thickness had similar standard (ketorolac)

Язык: Английский

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Investigation on the pharmacological profile for new synthesized bis heterocyclic analogs containing nitrogen atom as anti-cancer therapy target

Journal of Molecular Structure, Год журнала: 2024, Номер 1312, С. 138450 - 138450

Опубликована: Апрель 30, 2024

Язык: Английский

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Phosphorus-Containing Alkynes in the Synthesis of Heterocyclic Compounds (A Review)

Russian Journal of General Chemistry, Год журнала: 2024, Номер 94(3), С. 558 - 590

Опубликована: Март 1, 2024

Язык: Английский

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Pyrrole: An Essential Framework in the Development of Therapeutic Agents and Insightful Analysis of Structure‐Active Relationships

ChemistrySelect, Год журнала: 2024, Номер 9(31)

Опубликована: Авг. 16, 2024

Abstract Pyrrole is a heterocyclic structure with diverse pharmacophores, enabling the creation of an extensive lead molecule library. Its broad range pharmacological profiles has concerned significant global research interests. This review highlights recent advancements in pyrrole scaffolds, focusing on their active relationship and bioactivities. derivatives recognized for biological activities, are promising scaffolds developing antimicrobial, antimalarial, antiviral, antituberculosis, enzyme‐inhibiting properties. Their unique anti‐inflammatory antioxidant features have prompted development novel cardioprotective neuroprotective compounds. The aims to elucidate SAR mimics, aiding future therapeutic developments.

Язык: Английский

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Heterocycles in Medicinal Chemistry II

Molecules, Год журнала: 2024, Номер 29(20), С. 4810 - 4810

Опубликована: Окт. 11, 2024

Carbon has a unique position among the elements, due to fact that its valence shell four electrons and is therefore quadrivalent in excited state [...]

Язык: Английский

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