A review of the application of fibrous nano-silica (KCC-1) as nanocatalysts in the preparation of heterocyclic ring frameworks DOI
Sara Payamifar, Majid Abdouss, Ahmad Poursattar Marjani

et al.

Journal of Organometallic Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 123687 - 123687

Published: April 1, 2025

Language: Английский

New 1,2,3-triazole-quinazolinone skeleton as potential cholinesterase and α-amylase inhibitors: In vitro and in silico studies DOI
Esra Erdoğan, Özge Güngör, Seyit Ali Güngör

et al.

Journal of Molecular Liquids, Journal Year: 2025, Volume and Issue: 424, P. 126986 - 126986

Published: Jan. 22, 2025

Citations

0
In silico Repurposing of FDA-Approved Drugs as Multi-target Inhibitors of Glioblastoma DOI Creative Commons
Ridwan Abiodun Salaam, Funmilayo I. D. Afolayan,

Damilare Adebayo Olaniyi

et al.

Scientific African, Journal Year: 2025, Volume and Issue: unknown, P. e02582 - e02582

Published: Feb. 1, 2025

Language: Английский

Citations

0
One-pot, three-component synthesis and in vitro anti-bacterial evaluation of some novel chromeno[4,3-d]pyrimidine, thiazol-2H-chromens, and thiadiazol-2H-chromen derivatives DOI
Behjat Pouramiri, Maryam Sharifi,

Fatemeh Riyahi Zaniani

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 141658 - 141658

Published: Feb. 1, 2025

Language: Английский

Citations

0
In Silico Prediction, Molecular Docking Study for Identification of Novel Nitrogen Substituted Benzoxazole Derivative for Their Potential Biological Activity DOI
Hemant Chikhale, Dinesh Rishipathak

Chemistry Africa, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 13, 2025

Language: Английский

Citations

0
Thiourea compounds as multifaceted bioactive agents in medicinal chemistry DOI

Adeeba Khan,

Palak Dawar,

Suranjan De

et al.

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 158, P. 108319 - 108319

Published: Feb. 27, 2025

Language: Английский

Citations

0
Synthesis, Molecular modelling, and antimicrobial activity of new triazole-thiophene compounds DOI
Matokah M. Abualnaja,

Shaker T. Alsharif,

Alaa M. Alqahtani

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 141898 - 141898

Published: Feb. 1, 2025

Language: Английский

Citations

0
Decoding the interaction of an imidazo-pyrimidine derivative with serum proteins: Spectroscopic, computational and structure-activity relationship analysis DOI

Bidhan Chandra Chakraborty,

Ashok Santra,

Debangana Tah

et al.

Biophysical Chemistry, Journal Year: 2025, Volume and Issue: 322, P. 107435 - 107435

Published: March 14, 2025

Language: Английский

Citations

0
The anti-cancer effectiveness of some heterocyclic compounds containing sulfur atom DOI Creative Commons

Hasan Tuhmaz Hamad

Results in Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 102182 - 102182

Published: March 1, 2025

Language: Английский

Citations

0
Synthesis of New Thiazole‐Pyrazole Analogues: Molecular Modelling, Antiproliferative/Antiviral Activities, and ADME Studies DOI

Hind Ahmed Siddiq,

Mohammed A. Imam,

Shaker T. Alsharif

et al.

Chemical Biology & Drug Design, Journal Year: 2025, Volume and Issue: 105(3)

Published: March 1, 2025

ABSTRACT Twelve thiazole‐pyrazole analogues 4 , 6 and 8 were synthesized by introducing various pyrazole systems into the core, 2‐((4‐acetylphenyl)amino)‐4‐methylthiazole ( 2 ), through many synthetic approaches. The density functional theory (DFT) study of revealed coincided configurations their highest occupied lowest unoccupied molecular orbitals (HOMO LUMO), except for nitro derivatives, in which intramolecular charge‐transfer (CT) may be denoted as π → π* n π*. In addition, vitro antiproliferative efficacy towards some cancer cell lines was examined (Panc‐1, HT‐29, MCF‐7) non‐cancerous (WI‐38), using Dasatinib (Reference). 4c 4d demonstrated most potent anticancer effect, particularly against Panc‐1 MCF‐7 cells. Moreover, antiviral activity H5N1, a plaque reduction assay, showed that analogue 6a exhibited (100% inhibition TC 50 = 61 μg/μL), comparable to reference drug amantadine (TC 72 μg/μL, 100% inhibition). Furthermore, docking disclosed range interactions, such H‐bonding π‐π stacking, with binding affinities between −4.8558 − 8.3673 kcal/mol. Additionally, SwissADME predictions indicated possess promising drug‐like characteristics, but 4a–d 8c inadequate solubility bioavailability, restricts use viable oral medications.

Language: Английский

Citations

0
Amino Acid- and Peptide-conjugated Heterocyclic Compounds: A Comprehensive Review of Synthesis Strategies and Biological Activities DOI

Fany Sylvianingsih,

Unang Supratman, Rani Maharani

et al.

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 117534 - 117534

Published: March 1, 2025

Language: Английский

Citations

0