A Review on Medicinally Important Heterocyclic Compounds

The Open Medicinal Chemistry Journal, Год журнала: 2022, Номер 16(1)

Опубликована: Апрель 28, 2022

Heterocyclic compounds account for the most prominent and diverse class of organic compounds. A significant number heterocyclic have been synthesized up to this point. are rapidly increasing in due extensive synthetic research also their utility. Such a wide range uses field medicinal chemistry. Dyestuff, sanitizers, corrosion inhibitors, antioxidants, copolymer synthesis additional well-known applications. There always distinguishing characteristics an efficient approach producing newly discovered moieties. According prior research, more than 90% medicines containing developed after obtainment thorough scientific grasp biological system. It was neoteric developments that these play vital role curative chemistry, exert anticancer, anti-inflammatory, antifungal, antiallergic, antibacterial, anti-HIV, antiviral, anti-convulsant, other activities. The present article provides detailed information regarding such

Язык: Английский

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Synthesis, antibacterial and antioxidant activities of Thiazole-based Schiff base derivatives: a combined experimental and computational study

BMC Chemistry, Год журнала: 2021, Номер 15(1)

Опубликована: Дек. 23, 2021

Thiazole-based Schiff base compounds display significant pharmacological potential with an ability to modulate the activity of many enzymes involved in metabolism. They also demonstrated have antibacterial, antifungal, anti-inflammatory, antioxidant, and antiproliferative activities. In this work, conventional green approaches using ZnO nanoparticles as catalyst were used synthesize thiazole-based compounds.

Язык: Английский

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Seeking heterocyclic scaffolds as antivirals against dengue virus

European Journal of Medicinal Chemistry, Год журнала: 2022, Номер 240, С. 114576 - 114576

Опубликована: Июль 3, 2022

Язык: Английский

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Structural, Spectral, Molecular Docking, and Molecular Dynamics Simulations of Phenylthiophene-2-Carboxylate Compounds as Potential Anticancer Agents

Polycyclic aromatic compounds, Год журнала: 2023, Номер 44(1), С. 238 - 260

Опубликована: Фев. 1, 2023

Important biological compounds, namely, methyl 3-amino-4-(4-bromophenyl)thiophene-2-carboxylate (BPTC) and 3-amino-4-(4-chlorophenyl)thiophene-2-carboxylate (CPTC), were characterized using complementary techniques of Fourier transform infrared (FT-IR), Raman spectroscopy. Nuclear magnetic resonance spectroscopy (NMR) confirmed the structural features, while Ultra Violet–Visible Spectroscopy was used to investigate electronic properties both compounds. The quantum chemical calculations for compounds performed DFT/B3LYP functional with 6-311++G(d,p) basis set. This study computes electrostatic potential observation, electron localization function (ELF) assessment, atoms-in-molecules (AIM) analysis. In present investigation, global hardness, softness, electrophilicity, nucleophilicity indices, dipole moment calculated. addition, a molecular docking analysis conducted determine binding target molecules protein tyrosine phosphatase. A 200-ns dynamics (MDs) simulation had been assess compound’s stability.

Язык: Английский

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Anticancer Potential of the S‐Heterocyclic Ring Containing Drugs and its Bioactivation to Reactive Metabolites

Chemistry & Biodiversity, Год журнала: 2024, Номер 21(7)

Опубликована: Май 9, 2024

Sulfur-containing heterocyclic derivatives have been disclosed for binding with a wide range of cancer-specific protein targets. Various interesting sulfur-containing heterocyclics such as benzothiazole, thiazole, thiophene, thiazolidinedione, benzothiophene, and phenothiazine, etc shown to inhibit diverse signaling pathways implicated in cancer. Significant progress has also made molecular targeted therapy against specific enzymes kinase receptors due potential interactions inside the ATP pocket. ring metal complexes i. e., benzothiophene phenothiazines are among most promising active anticancer compounds. However, sulfur heteroaromatic rings, particularly high structural alert their metabolism reactive metabolites. The mere presence itself does not determine compound toxicity therefore, this review focuses on some findings that shed light factors influencing toxicity. In current review, synthetic strategies introducing core synthesized discussed structure-activity relationships enhance our understanding mechanisms develop safer therapeutic options. marketed drugs included direct synthesis novel compounds will help development potent, sulfur-based near future.

Язык: Английский

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β-carotene Supply to Dill Plants Grown in Sulphur and Humic Acid-amended Soil Improves Salinity Tolerance via Quenching the Hazard Molecules

Russian Journal of Plant Physiology, Год журнала: 2024, Номер 71(1)

Опубликована: Фев. 1, 2024

Язык: Английский

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Multitarget Pharmacology of Sulfur–Nitrogen Heterocycles: Anticancer and Antioxidant Perspectives

Antioxidants, Год журнала: 2024, Номер 13(8), С. 898 - 898

Опубликована: Июль 25, 2024

Cancer and oxidative stress are interrelated, with reactive oxygen species (ROS) playing crucial roles in physiological processes oncogenesis. Excessive ROS levels can induce DNA damage, leading to cancer, disrupt antioxidant defenses, contributing diseases like diabetes cardiovascular disorders. Antioxidant mechanisms include enzymes small molecules that mitigate damage. However, cancer cells often exploit conditions evade apoptosis promote tumor growth. therapy has shown mixed results, timing cancer-type influencing outcomes. Multifunctional drugs targeting multiple pathways offer a promising approach, reducing side effects improving efficacy. Recent research focuses on sulfur-nitrogen heterocyclic derivatives for their dual anticancer properties, potentially enhancing therapeutic efficacy oncology. The newly synthesized compounds do not demonstrate both properties simultaneously. Heterocyclic rings typically combined phenyl groups, where hydroxy substitutions enhance activity. On the other hand, electron-withdrawing substituents, particularly at p-position ring, tend

Язык: Английский

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Chitosan-based Schiff base polymer derived from acetyl triazolyl uracil: Synthesis, characterization, evaluation of antimicrobial and antioxidant activities, and density functional theory calculations

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 140327 - 140327

Опубликована: Янв. 1, 2025

Язык: Английский

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Drugs and Their Mode of Action: A Review on Sulfur-Containing Heterocyclic Compounds

Polycyclic aromatic compounds, Год журнала: 2024, Номер unknown, С. 1 - 40

Опубликована: Авг. 27, 2024

Sulfur-containing heterocyclic compounds have emerged as an important class of bioactive molecules in drug discovery owing to their diverse pharmacological activities and unique modes action. Sulfur drugs exert actions primarily through ability interfere with microbial growth modulate immune responses. The provided showed a spectrum ring structures varying sizes, from three- seven-membered rings, each influencing the medicinal potency compounds. Smaller such four-membered often impart reactivity functional properties, potentially leading potent effects. Conversely, larger six- may offer increased structural stability favorable interactions biological targets, enhancing Understanding relationship between size is crucial design facilitate development therapeutics optimized efficacy pharmacokinetic properties. This review provides comprehensive overview that contain sulfur-containing key motifs, action, specific protein enzymes, receptors, cellular processes. Moreover, we highlight potential candidates for treating numerous diseases significance research.

Язык: Английский

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Boosting the antimicrobial performance based on new fused spirothiazolidine framework analogs

Journal of the Iranian Chemical Society, Год журнала: 2022, Номер 19(10), С. 4223 - 4236

Опубликована: Июль 6, 2022

Abstract New spiro[cyclohexane-1,2'-thiazolo[4,5- b ]pyridine derivatives ( 3 – 23 ) were investigated. Then there is in vitro antimicrobial potency against possible organisms Staphylococcus aurous ATCC-47,077, Bacillus cereus ATCC-12228, Escherichia coli ATCC-25922, Salmonella typhi ATCC-15566, and Candida albicans ATCC-10231 tested utilizing commercially available antibiotics ampicillin as a reference drug. A preliminary test represented that derivatives: (Aldoses) 3'-(4-fluorophenyl)-5'-(methyleneamino)-7'-( p -tolyl)- 3'H -spiro[cyclohexane-1,2'-thiazolo[4,5-b]pyridine]-6'-carbonitrile 16–19 (Acetyl aldoses) -spiro [cyclohexane-1,2'-thiazolo[4,5-b]pyridine]-6'-carbonitrile 20–23 exhibited higher antifungal, antibacterial performance with minimum inhibitory concentrations values of (39–67 µg/ml) toward all pathogenic strains compared to common drug ampicillin.

Язык: Английский

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