Salidroside: An Overview of Its Promising Potential and Diverse Applications
Pharmaceuticals,
Год журнала:
2024,
Номер
17(12), С. 1703 - 1703
Опубликована: Дек. 17, 2024
Salidroside,
a
phenolic
compound
isolated
from
various
Rhodiola
plants,
is
the
principal
active
constituent
of
Traditional
Chinese
Medicine
known
for
its
adaptogenic
properties.
Due
to
challenging
environment
species,
such
as
high
altitude,
radiation,
drought,
and
hypoxia,
source
salidroside
scarce.
However,
numerous
studies
have
shown
that
has
range
biological
activities,
including
cardiovascular
central
nervous
system
activity,
anti-hypoxia,
anti-inflammatory,
anti-aging
activities.
Although
previous
partially
summarized
pharmacological
effects
salidroside,
overall
not
been
analyzed.
Hence,
this
review
will
systematically
summarize
isolation,
purification,
synthesis,
derivatization,
pharmacokinetics,
clinical
application,
safety
salidroside.
It
expected
provide
new
insights
further
research
pharmaceutical
development
Язык: Английский
Real-Time Cardiac Abnormality Monitoring and Nursing for Patient Using Electrocardiographic Signals
Huamin Ao,
Enjian Zhai,
Le Jiang
и другие.
Cardiology,
Год журнала:
2024,
Номер
unknown, С. 1 - 11
Опубликована: Июнь 17, 2024
<b><i>Introduction:</i></b>
Cardiovascular
disease
nursing
is
a
critical
clinical
application
that
necessitates
real-time
monitoring
models.
Previous
models
required
the
use
of
multi-lead
signals
and
could
not
be
customized
as
needed.
Traditional
methods
relied
on
manually
designed
supervised
algorithms,
based
empirical
experience,
to
identify
waveform
abnormalities
classify
diseases,
were
incapable
alerting
in
individual
waveforms.
<b><i>Methods:</i></b>
This
research
reconstructed
vector
model
for
arbitrary
leads
using
phase
space-time-delay
method,
enabling
arbitrarily
combine
needed
while
possessing
adaptive
denoising
capabilities.
After
employing
automatically
constructed
machine
learning
algorithms
designing
rapid
convergence,
can
waveforms
well
detect
alert
abnormal
<b><i>Result:</i></b>
Effective
noise
elimination
was
achieved,
obtaining
higher
degree
loss
function
fitting.
utilizing
algorithm
Section
3.1
remove
noise,
signal-to-noise
ratio
increased
by
8.6%.
A
clipping
employed
significantly
affected
external
factors.
Subsequently,
network
established
generative
utilized.
The
accuracy
healthy
patients
reached
99.2%,
APB
100%,
LBBB
99.32%,
RBBB
99.1%,
P-wave
peak
98.1%.
<b><i>Conclusion:</i></b>
By
three-dimensional
model,
detailed
variations
electrocardiogram
associated
with
different
diseases
observed.
effective
identifying
perturbed
damaged
Automated
neural
networks
patient
identities
facilitate
precision
nursing.
Язык: Английский
Assessing the Clinical Outcomes of Dazhu Hongjingtian Injection for the Management of Stable and Unstable Angina: Protocol for a Prospective Observational Study
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Фев. 13, 2024
Abstract
Background
The
global
rise
in
angina
pectoris,
a
symptom
of
coronary
artery
disease,
is
primarily
attributed
to
an
aging
population
and
increasing
prevalence
comorbidities.
This
study
aims
assess
the
efficacy
safety
Dazhu
Hongjingtian
injection
(DZHJTI)
as
adjunct
treatment
for
both
stable
unstable
angina,
thereby
addressing
significant
gap
current
cardiac
care
research.
Methods
comprehensive
involves
two
parallel
prospective
cohorts
across
28
medical
centers
China,
enrolling
1,500
patients
with
2,000
angina.
Participants
are
randomized
into
groups:
one
receiving
DZHJTI
alongside
standard
therapy,
other
therapy
alone.
employs
advanced
statistical
methods
like
Subgroup
Analysis
(SGA)
Marginal
Mean
Weighting
Through
Stratification
(MMWS)
analyze
data
accurately.
Discussion
primary
outcome
this
reduction
frequency
attacks
post-treatment.
Secondary
outcomes
include
evaluation
patient
wellbeing
through
clinical
measures
such
nitrate
dosage
requirements,
vital
sign
stability,
ECG
changes,
laboratory
data.
Patient-reported
from
targeted
questionnaires
will
also
be
assessed
understand
impact
on
quality
life.
study's
results
expected
contribute
significantly
understanding
DZHJTI's
role
treating
potentially
influencing
future
guidelines.
Trial
registration:
http://itmctr.ccebtcm.org.cn/
,
ITMCTR2022000006
Язык: Английский
Assessing the clinical outcomes of Dazhu Hongjingtian injection for the management of stable and unstable angina: Protocol for a prospective observational study
Deleted Journal,
Год журнала:
2024,
Номер
2(2), С. 62 - 67
Опубликована: Июнь 1, 2024
Background:
The
global
rise
in
angina
pectoris,
a
symptom
of
coronary
artery
disease,
is
primarily
attributed
to
an
aging
population
and
increasing
prevalence
comorbidities.
This
study
aims
assess
the
efficacy
safety
Dazhu
Hongjingtian
injection
(DZHJTI)
as
adjunct
treatment
for
both
stable
unstable
angina,
thereby
addressing
significant
gap
current
cardiac
care
research.
Methods:
comprehensive
involves
2
parallel
prospective
cohorts
across
28
medical
centers
China,
enrolling
1500
patients
with
2000
angina.
Participants
are
randomized
into
groups:
one
receiving
DZHJTI
alongside
standard
therapy
other
alone.
employs
advanced
statistical
methods
like
Subgroup
Analysis
Marginal
Mean
Weighting
Through
Stratification
analyze
data
accurately.
Discussion:
primary
outcome
this
reduction
frequency
attacks
posttreatment.
Secondary
outcomes
include
evaluation
patient
well-being
through
clinical
measures
such
nitrate
dosage
requirements,
vital
sign
stability,
electrocardiogram
changes,
laboratory
data.
Patient-reported
from
targeted
questionnaires
will
also
be
assessed
understand
impact
on
quality
life.
study’s
results
expected
contribute
significantly
understanding
DZHJTI’s
role
treating
potentially
influencing
future
guidelines.
Язык: Английский