Assessing the clinical outcomes of Dazhu Hongjingtian injection for the management of stable and unstable angina: Protocol for a prospective observational study DOI Creative Commons
Song Tian, Qianzi Che, Ning Liang

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: 2(2), P. 62 - 67

Published: June 1, 2024

Background: The global rise in angina pectoris, a symptom of coronary artery disease, is primarily attributed to an aging population and increasing prevalence comorbidities. This study aims assess the efficacy safety Dazhu Hongjingtian injection (DZHJTI) as adjunct treatment for both stable unstable angina, thereby addressing significant gap current cardiac care research. Methods: comprehensive involves 2 parallel prospective cohorts across 28 medical centers China, enrolling 1500 patients with 2000 angina. Participants are randomized into groups: one receiving DZHJTI alongside standard therapy other alone. employs advanced statistical methods like Subgroup Analysis Marginal Mean Weighting Through Stratification analyze data accurately. Discussion: primary outcome this reduction frequency attacks posttreatment. Secondary outcomes include evaluation patient well-being through clinical measures such nitrate dosage requirements, vital sign stability, electrocardiogram changes, laboratory data. Patient-reported from targeted questionnaires will also be assessed understand impact on quality life. study’s results expected contribute significantly understanding DZHJTI’s role treating potentially influencing future guidelines.

Language: Английский

Salidroside: An Overview of Its Promising Potential and Diverse Applications DOI Creative Commons
Keke Liang, Shuhe Ma, Kai Luo

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(12), P. 1703 - 1703

Published: Dec. 17, 2024

Salidroside, a phenolic compound isolated from various Rhodiola plants, is the principal active constituent of Traditional Chinese Medicine known for its adaptogenic properties. Due to challenging environment species, such as high altitude, radiation, drought, and hypoxia, source salidroside scarce. However, numerous studies have shown that has range biological activities, including cardiovascular central nervous system activity, anti-hypoxia, anti-inflammatory, anti-aging activities. Although previous partially summarized pharmacological effects salidroside, overall not been analyzed. Hence, this review will systematically summarize isolation, purification, synthesis, derivatization, pharmacokinetics, clinical application, safety salidroside. It expected provide new insights further research pharmaceutical development

Language: Английский

Citations

2
Real-Time Cardiac Abnormality Monitoring and Nursing for Patient Using Electrocardiographic Signals DOI

Huamin Ao,

Enjian Zhai,

Le Jiang

et al.

Cardiology, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 11

Published: June 17, 2024

<b><i>Introduction:</i></b> Cardiovascular disease nursing is a critical clinical application that necessitates real-time monitoring models. Previous models required the use of multi-lead signals and could not be customized as needed. Traditional methods relied on manually designed supervised algorithms, based empirical experience, to identify waveform abnormalities classify diseases, were incapable alerting in individual waveforms. <b><i>Methods:</i></b> This research reconstructed vector model for arbitrary leads using phase space-time-delay method, enabling arbitrarily combine needed while possessing adaptive denoising capabilities. After employing automatically constructed machine learning algorithms designing rapid convergence, can waveforms well detect alert abnormal <b><i>Result:</i></b> Effective noise elimination was achieved, obtaining higher degree loss function fitting. utilizing algorithm Section 3.1 remove noise, signal-to-noise ratio increased by 8.6%. A clipping employed significantly affected external factors. Subsequently, network established generative utilized. The accuracy healthy patients reached 99.2%, APB 100%, LBBB 99.32%, RBBB 99.1%, P-wave peak 98.1%. <b><i>Conclusion:</i></b> By three-dimensional model, detailed variations electrocardiogram associated with different diseases observed. effective identifying perturbed damaged Automated neural networks patient identities facilitate precision nursing.

Language: Английский

Citations

1
Assessing the Clinical Outcomes of Dazhu Hongjingtian Injection for the Management of Stable and Unstable Angina: Protocol for a Prospective Observational Study DOI Creative Commons
Song Tian, Qianzi Che, Ning Liang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 13, 2024

Abstract Background The global rise in angina pectoris, a symptom of coronary artery disease, is primarily attributed to an aging population and increasing prevalence comorbidities. This study aims assess the efficacy safety Dazhu Hongjingtian injection (DZHJTI) as adjunct treatment for both stable unstable angina, thereby addressing significant gap current cardiac care research. Methods comprehensive involves two parallel prospective cohorts across 28 medical centers China, enrolling 1,500 patients with 2,000 angina. Participants are randomized into groups: one receiving DZHJTI alongside standard therapy, other therapy alone. employs advanced statistical methods like Subgroup Analysis (SGA) Marginal Mean Weighting Through Stratification (MMWS) analyze data accurately. Discussion primary outcome this reduction frequency attacks post-treatment. Secondary outcomes include evaluation patient wellbeing through clinical measures such nitrate dosage requirements, vital sign stability, ECG changes, laboratory data. Patient-reported from targeted questionnaires will also be assessed understand impact on quality life. study's results expected contribute significantly understanding DZHJTI's role treating potentially influencing future guidelines. Trial registration: http://itmctr.ccebtcm.org.cn/ , ITMCTR2022000006

Language: Английский

Citations

0
Assessing the clinical outcomes of Dazhu Hongjingtian injection for the management of stable and unstable angina: Protocol for a prospective observational study DOI Creative Commons
Song Tian, Qianzi Che, Ning Liang

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: 2(2), P. 62 - 67

Published: June 1, 2024

Background: The global rise in angina pectoris, a symptom of coronary artery disease, is primarily attributed to an aging population and increasing prevalence comorbidities. This study aims assess the efficacy safety Dazhu Hongjingtian injection (DZHJTI) as adjunct treatment for both stable unstable angina, thereby addressing significant gap current cardiac care research. Methods: comprehensive involves 2 parallel prospective cohorts across 28 medical centers China, enrolling 1500 patients with 2000 angina. Participants are randomized into groups: one receiving DZHJTI alongside standard therapy other alone. employs advanced statistical methods like Subgroup Analysis Marginal Mean Weighting Through Stratification analyze data accurately. Discussion: primary outcome this reduction frequency attacks posttreatment. Secondary outcomes include evaluation patient well-being through clinical measures such nitrate dosage requirements, vital sign stability, electrocardiogram changes, laboratory data. Patient-reported from targeted questionnaires will also be assessed understand impact on quality life. study’s results expected contribute significantly understanding DZHJTI’s role treating potentially influencing future guidelines.

Language: Английский

Citations

0