Noninvasive dynamic vascular imaging: arterial spin labeling-based noncontrast magnetic resonance digital subtraction angiography for cerebral disease diagnoses

Japanese Journal of Radiology, Год журнала: 2025, Номер unknown

Опубликована: Март 12, 2025

Abstract Digital subtraction angiography (DSA) is the gold standard for assessing cerebrovascular hemodynamics. DSA predominantly utilized to evaluate hemodynamic information of various cerebral diseases. However, relatively invasive and involves radiation exposure risks allergic reactions or renal dysfunction related iodine-based contrast agents. Magnetic resonance (MRDSA) with a gadolinium-based agent popular method hemodynamics without exposure. it has disadvantage risk allergy due lower temporal spatial resolution than DSA. In recent years, arterial spin labeling-based noncontrast MRDSA (ASL-MRDSA), which utilizes blood labeled radiofrequency pulses as an endogenous tracer, been developed. ASL-MRDSA exhibits same DSA; therefore, can yield dynamic about Pulsed ASL used major labeling method. development pseudocontinuous enabled high signal maintenance even at delayed phases. This advancement allows more detailed assessment vascular diseases, including artery severe stenosis, occlusion, moyamoya disease. Furthermore, combining superselective also complex malformations such addition, using ultrashort-echo time acquire signals before phase dispersion occurs, reduces artifacts induced by metallic materials flow. technique useful post-clipping, post-coiling, pseudostenosis. wheel scan mode full sampling achieves higher DSA, enables flow evaluation within giant aneurysms. Herein, we introduce basic principles novel techniques demonstrate its clinical applications, pitfalls, limitations in disease diagnoses.

Язык: Английский

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Diagnostic accuracy of MRI without gadolinium for follow-up of pilocytic astrocytoma in the paediatric population

Journal of Clinical Neuroscience, Год журнала: 2025, Номер 135, С. 111173 - 111173

Опубликована: Март 13, 2025

Язык: Английский

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Strukturelle Veränderungen des Herzens bei Patienten mit chronischer Nierenerkrankung

Nephrologie aktuell, Год журнала: 2025, Номер 29(02), С. 72 - 77

Опубликована: Март 1, 2025

Zusammenfassung In Deutschland sind ca. 8–10 Millionen Menschen von chronischer Nierenkrankheit (CKD) betroffen, wobei einer hohen Dunkelziffer auszugehen ist, da die CKD vor allem im Frühstadium nicht immer richtig erkannt wird. Die CKD, hauptsächlich durch kardiovaskuläre Risikofaktoren wie Diabetes mellitus (DM) und arterielle Hypertonie (HAT) verursacht wird, kann Verlauf erhebliche Auswirkungen auf das Herz haben zu strukturellen Veränderungen linksventrikulärer Hypertrophie (LVH), Kalzifizierung, Fibrosierung diastolischer Dysfunktion führen. Diese können in einem Teufelskreis Fortschreiten der begünstigen, indem sie schwere Klappenvitien verursachen, Reduktion systolischen Funktion führen können, was wiederum Volumenmanagement erheblich erschweren kann. Diagnostische Verfahren Echokardiografie oder Magnetresonanztomografie hier wichtige Informationen zur Erkennung dieser liefern. Wie Medizin ist Vorbeugung beste Therapie. Daher müssen wir Ärzte beide Organe ihre Wechselwirkungen genau verstehen, um rechtzeitig eingreifen können. diesem Rahmen kardionephrologische Konferenzen für einen besseren Wissensaustausch eine bessere Therapie notwendig.

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Axial Spondyloarthritis: Updates in Concepts and Reporting in Radiology

Seminars in Musculoskeletal Radiology, Год журнала: 2025, Номер 29(02), С. 196 - 209

Опубликована: Март 31, 2025

Abstract Axial spondyloarthritis (axSpA) is a chronic inflammatory disease primarily affecting the axial skeleton, historically termed “human leukocyte antigen B27 positive spondyloarthropathy” or ankylosing spondylitis. Improved understanding of underlying pathologic mechanisms has led to an ongoing redefinition this state, recognition substantial phenotypic and biological variation, emphasis on earlier detection. Magnetic resonance imaging become central identifying confirming early axSpA, critical fulfilling promise slowing progression preventing irreversible structural abnormalities. We review clinical background current role medical in with focus Assessment SpondyloArthritis International Society consensus definitions, improve radiology reporting facilitate discussion between radiologists other experts spondyloarthritis.

Язык: Английский

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Methodological Concerns Regarding the Association Between Gadolinium-Based Contrast Agents and Parkinson Disease

Investigative Radiology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 3, 2025

Язык: Английский

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Gadolinium Toxicity: Mechanisms, Clinical Manifestations, and Nanoparticle Role

Опубликована: Апрель 29, 2025

Gadolinium-based contrast agents (GBCAs), essential for MRI, are facing renewed scrutiny due to gadolinium (Gd) retention and emerging toxicity profiles. While the link between less stable Nephrogenic Systemic Fibrosis (NSF) in renal impairment is established, deposition also observed brain, bone, skin across all GBCA classes, even patients with normal function. This finding has raised concerns led controversial concept of Gadolinium Deposition Disease (GDD). The present review synthesizes current evidence on clinical manifestations underlying mechanisms. It highlights pathways beyond traditional transmetallation, particularly endogenous nanoparticle formation as a key mechanism Gd release retention, potentially challenging stability assumptions macrocyclic agents. Structural factors (linear/macrocyclic; ionic/non-ionic) parameters (thermodynamic log K; kinetic kobs) influencing risk evaluated alongside regulatory responses. GBCAs should be viewed not inert diagnostics but complex, cumulative biological interactions. Future research focus developing non-gadolinium alternatives, validating biomarkers early detection conducting controlled trials chelation therapy efficacy. Clinicians must balance diagnostic benefits potential long-term risks, ensuring informed patient consent judicious use.

Язык: Английский

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Guidelines and Controversies of Computed Tomography and Magnetic Resonance Imaging Contrast Media

Radiologic Clinics of North America, Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

Язык: Английский

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Magnetic Resonance Imaging in the Clinical Evaluation of Lung Disorders: Current Status and Future Prospects

Journal of Magnetic Resonance Imaging, Год журнала: 2025, Номер unknown

Опубликована: Май 9, 2025

ABSTRACT The low proton density and high signal decay rate of pulmonary tissue have previously hampered the application magnetic resonance imaging (MRI) in clinical evaluation lung disorders. With continuing technical advances scanners, coils, pulse sequences, image postprocessing, MRI can provide structural functional information with faster speed improved quality, which has shown potential to be an alternative complementary diagnostic method chest computed tomography (CT). Compared CT, does not involve ionizing radiation, making it particularly suitable for pediatric patients, pregnant women, individuals requiring longitudinal monitoring. This narrative review focuses on recent techniques applications diseases, including parenchymal vascular diseases. Future developments, artificial intelligence‐driven technological optimization assisted diagnosis, hardware advancements, biomarkers validation, hold further enhance utility MRI. Evidence Level 5 Technical Efficacy Stage 2

Язык: Английский

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Automatic Active Lesion Tracking in Multiple Sclerosis Using Unsupervised Machine Learning

Diagnostics, Год журнала: 2024, Номер 14(6), С. 632 - 632

Опубликована: Март 16, 2024

Background: Identifying active lesions in magnetic resonance imaging (MRI) is crucial for the diagnosis and treatment planning of multiple sclerosis (MS). Active on MRI are identified following administration Gadolinium-based contrast agents (GBCAs). However, recent studies have reported that repeated GBCA results accumulation Gd tissues. In addition, increases health care costs. Thus, reducing or eliminating lesion detection important improved patient safety reduced healthcare Current state-of-the-art methods identifying brain without utilize data-intensive deep learning methods. Objective: To implement nonlinear dimensionality reduction (NLDR) methods, locally linear embedding (LLE) isometric feature mapping (Isomap), which less data-intensive, automatically MS patients, agents. Materials Methods: Fluid-attenuated inversion recovery (FLAIR), T2-weighted, proton density-weighted, pre- post-contrast T1-weighted images were included multiparametric dataset used this study. Subtracted labeled by experts as (ground truth). Unsupervised LLE Isomap, to reconstruct MR into a single embedded image. compared with ground truth lesions. The performance NLDR was evaluated calculating Dice similarity (DS) index between observed images. Results: applied 40 achieving median DS scores 0.74 ± 0.1 0.78 0.09, respectively, outperforming current Conclusions: Isomap LLE, viable options identification non-contrast images, potentially could be clinical decision tool.

Язык: Английский

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A novel albumin-binding macrocyclic Gd-HPDO3A complex bearing a deoxycholic acid residue: the role of the hydration state, water exchange and local dynamics in the observed relaxivity

Inorganic Chemistry Frontiers, Год журнала: 2024, Номер 11(19), С. 6511 - 6526

Опубликована: Янв. 1, 2024

Improved efficiency of an HSA-binding Gd-complex: the role hydration state, water exchange and local dynamics in observed relaxivity a highly stable macrocyclic Gd-HPDO3A complex bearing deoxycholic acid residue.

Язык: Английский

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