Global research hotspots and trends in DNA vaccine research: A bibliometric and visualization study from 2014 to 2024 DOI Creative Commons
Juan Zhang,

Haiguo Zhang,

Cuicui Yao

и другие.

Human Vaccines & Immunotherapeutics, Год журнала: 2025, Номер 21(1)

Опубликована: Янв. 27, 2025

This bibliometric and visualization study provides a comprehensive analysis of global research hotspots trends in DNA vaccine from 2014 to 2024. By employing data sourced the Web Science Core Collection, we identified total 3,600 articles. Our reveals declining trend annual publications. Active countries, institutions, journals, authors were identified, with China, Pasteur Network, Vaccine Journal, David B Weiner being most prolific contributors. Keywords cluster distinguished four major directions: infectious disease immunity, viral challenge development, optimization delivery systems, cancer immunotherapy research. The literature co-citation revealed hotspots, including vaccines for Zika virus, human papillomavirus (HPV), COVID-19, as well safety, efficacy, immunogenicity studies vaccines. Concurrently, burst citation emerging themes, development Ebola, MERS-CoV, innovations antigen design technologies. offers valuable insights into evolution future directions research, emphasizing its importance public health potential address current challenges.

Язык: Английский

Improved DNA Vaccine Delivery with Needle-Free Injection Systems DOI Creative Commons
Carmen Ledesma‐Feliciano, Rosamund Chapman, Jay W. Hooper

и другие.

Vaccines, Год журнала: 2023, Номер 11(2), С. 280 - 280

Опубликована: Янв. 28, 2023

DNA vaccines have inherent advantages compared to other vaccine types, including safety, rapid design and construction, ease speed manufacture, thermostability. However, a major drawback of candidate delivered by needle syringe is the poor immunogenicity associated with inefficient cellular uptake DNA. This essential because target antigen produced within cells then presented immune system. Multiple techniques been employed boost protective efficacy vaccines, physical delivery methods, molecular traditional adjuvants, genetic sequence enhancements. Needle-free injection systems (NFIS) are an attractive alternative due induction potent immunogenicity, enhanced efficacy, elimination needles. These led milestone achievement in field approval for Restricted Use Emergency Situation against COVID-19, exclusively NFIS. In this review, we discuss methods emphasis on commercially available NFIS their resulting immunogenic effectiveness, efficacy. As discussed, prophylactic tend induce non-inferior electroporation responses syringe.

Язык: Английский

Процитировано

67
Next-Generation TB Vaccines: Progress, Challenges, and Prospects DOI Creative Commons
Zhuang Li, Zhaoyang Ye, Linsheng Li

и другие.

Vaccines, Год журнала: 2023, Номер 11(8), С. 1304 - 1304

Опубликована: Июль 31, 2023

Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), is a prevalent global infectious disease and leading cause of mortality worldwide. Currently, the only available vaccine for TB prevention Bacillus Calmette-Guérin (BCG). However, BCG demonstrates limited efficacy, particularly in adults. Efforts to develop effective vaccines have been ongoing nearly century. In this review, we examined current obstacles research emphasized significance understanding interaction mechanism between MTB hosts order provide new avenues establish solid foundation development novel vaccines. We also assessed various candidates, including inactivated vaccines, attenuated live subunit viral vector DNA emerging mRNA as well virus-like particle (VLP)-based which are currently preclinical stages or clinical trials. Furthermore, discussed challenges opportunities associated with developing different types outlined future directions research, aiming expedite This comprehensive review offers summary progress made field

Язык: Английский

Процитировано

57
Tracking the COVID-19 vaccines: The global landscape DOI Creative Commons
Tushar Yadav,

Swatantra Kumar,

Gourav Mishra

и другие.

Human Vaccines & Immunotherapeutics, Год журнала: 2023, Номер 19(1)

Опубликована: Янв. 2, 2023

COVID-19, a respiratory infectious disease, occurs due to Severe acute syndrome coronavirus-2 (SARS-CoV-2). Millions of individuals around the world have been impacted by illness, which has gravely threatened human health. The development and active involvement varied vaccines against COVID-19 played great relieving role in controlling life-threatening disease. Both conventional advanced vaccine platforms are available now develop COVID-19. Therefore, present systematic review focuses on global landscape their current status. Among vaccines, virus like particles (VLPs), subunit DNA, RNA-based viral vector-based inactivated live-attenuated major contenders currently various phase clinical trials. Protein subunit, non-replicating used majorly. Nevertheless, utilized clinically world. trials revealed that most local or systemic effects after vaccination efficacy SARS-CoV-2 its variants. However, further studies necessary refine technology minimize adverse improve safety efficacy.Abbreviations COVID-19: Coronavirus disease 2019; SARS-CoV-2: coronavirus-2; VLPs: Virus particles; WHO: World Health Organization; E: Envelope; M: Membrane; S: Spike; N: Nucleocapsid; PRISMA: Preferred Reporting Items for Systematic Reviews Meta-Analyses; FDA: Food Drug Administration; LNP: lipid-nanoparticle; AZD1222: ChAdOx1 nCoV-19; BNT162b2: Pfizer-BioNTech mRNA vaccine; mRNA-1273: Moderna Ad26.COV2.S: Johnson – Janssen’s Gam-COVID-Vac: Sputnik Vaccine; NVX-CoV2373: Novavax with Matrix-M™ adjuvant.

Язык: Английский

Процитировано

51
An overview of the vaccine platforms to combat COVID-19 with a focus on the subunit vaccines DOI Open Access
Fatemeh Bayani,

Negin Safaei Hashkavaei,

Sareh Arjmand

и другие.

Progress in Biophysics and Molecular Biology, Год журнала: 2023, Номер 178, С. 32 - 49

Опубликована: Фев. 20, 2023

Язык: Английский

Процитировано

47
The next-generation DNA vaccine platforms and delivery systems: advances, challenges and prospects DOI Creative Commons
Bowen Lu,

Jing Ming Lim,

Boyue Yu

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Фев. 1, 2024

Vaccines have proven effective in the treatment and prevention of numerous diseases. However, traditional attenuated inactivated vaccines suffer from certain drawbacks such as complex preparation, limited efficacy, potential risks others. These limitations restrict their widespread use, especially face an increasingly diverse range With ongoing advancements genetic engineering vaccines, DNA emerged a highly promising approach both diseases acquired While several demonstrated substantial success animal models diseases, challenges need to be addressed before application human subjects. The primary obstacle lies absence optimal delivery system, which significantly hampers immunogenicity vaccines. We conduct comprehensive analysis current status by focusing on viral non-viral systems, they play crucial roles exploration novel provide evaluation strengths weaknesses based our critical assessment. Additionally, review summarizes most recent breakthroughs pre-clinical clinical studies, highlighting for further trials this rapidly evolving field.

Язык: Английский

Процитировано

41
DNA Vaccines: Their Formulations, Engineering and Delivery DOI Creative Commons
Michael Kozak, Jiafen Hu

Vaccines, Год журнала: 2024, Номер 12(1), С. 71 - 71

Опубликована: Янв. 11, 2024

The concept of DNA vaccination was introduced in the early 1990s. Since then, advancements augmentation immunogenicity vaccines have brought this technology to market, especially veterinary medicine, prevent many diseases. Along with successful COVID mRNA vaccines, first vaccine for human use, Indian ZyCovD against SARS-CoV-2, approved 2021. In current review, we give an overview focusing on science, including adjuvants and delivery methods. We then cover some emerging science field notably efforts optimize systems, better engineer apparatuses, identify optimal sites, personalize cancer immunotherapy through vaccination, enhance adjuvant gene adjuvants, off-target heritable immunity epigenetic modification, predict epitopes bioinformatic approaches. also discuss major limitations aim address theoretical concerns.

Язык: Английский

Процитировано

33
A comprehensive comparison of DNA and RNA vaccines DOI
Chunxi Wang,

Fan Yuan

Advanced Drug Delivery Reviews, Год журнала: 2024, Номер 210, С. 115340 - 115340

Опубликована: Май 27, 2024

Язык: Английский

Процитировано

19
DNA Vaccines: History, Molecular Mechanisms and Future Perspectives DOI Creative Commons

Sthefany Pagliari,

Bárbara Dema, Alexandra Sánchez-Martínez

и другие.

Journal of Molecular Biology, Год журнала: 2023, Номер 435(23), С. 168297 - 168297

Опубликована: Окт. 4, 2023

The history of DNA vaccine began as early the 1960s with discovery that naked can transfect mammalian cells in vivo. In 1992, evidence such transfection could lead to generation antigen-specific antibody responses was obtained and supported development this technology a novel platform. then attracted immense interest high hopes vaccinology, immunogenicity protection against virulent challenges accumulated from several animal models for diseases. particular, capacity induce T-cell unprecedented non-live vaccines. However, suffered its major knock when success animals failed translate humans, where candidates were shown be safe but remained poorly immunogenic, or not associated clinical benefit. Thanks thorough exploration molecular mechanisms action these vaccines, an impressive range approaches have been are currently being explored overcome challenge. Despite limited so far humans compared later genetic technologies viral vectors mRNA, vaccines yet optimised human use may still realise their potential.

Язык: Английский

Процитировано

23
Current Progress, Challenges and Prospects in the Development of COVID-19 Vaccines DOI
Congrui Zhu,

Shengmei Pang,

Jiaqi Liu

и другие.

Drugs, Год журнала: 2024, Номер 84(4), С. 403 - 423

Опубликована: Апрель 1, 2024

Язык: Английский

Процитировано

10
Clinical perspective on topical vaccination strategies DOI Creative Commons
Petya Popova, Sunny P. Chen,

Suiyang Liao

и другие.

Advanced Drug Delivery Reviews, Год журнала: 2024, Номер 208, С. 115292 - 115292

Опубликована: Март 24, 2024

Vaccination is one of the most successful measures in modern medicine to combat diseases, especially infectious and saves millions lives every year. Vaccine design development remains critical involves many aspects, including choice platform, antigen, adjuvant, route administration. Topical vaccination, defined herein as introduction a vaccine any three layers human skin, has attracted interest recent years an alternative vaccination approach conventional intramuscular administration because its potential be needle-free induce superior immune response against pathogens. In this review, we describe progress developing topical vaccines, highlight delivery technologies for discuss factors that might impact efficacy, provide overview current clinical landscape vaccines.

Язык: Английский

Процитировано

8