The Role of Fibroblasts in Skin Homeostasis and Repair

Biomedicines, Год журнала: 2024, Номер 12(7), С. 1586 - 1586

Опубликована: Июль 17, 2024

Fibroblasts are typical mesenchymal cells widely distributed throughout the human body where they (1) synthesise and maintain extracellular matrix, ensuring structural role of soft connective tissues; (2) secrete cytokines growth factors; (3) communicate with each other cell types, acting as signalling source for stem niches; (4) involved in tissue remodelling, wound healing, fibrosis, cancer. This review focuses on developmental heterogeneity dermal fibroblasts, their ability to sense changes biomechanical properties surrounding aging, skin repair, pathologic conditions tumour development. Moreover, we describe use fibroblasts different models (e.g., vivo animal vitro systems from 2D 6D cultures) bioengineering informative potential high-throughput assays study under disease contexts personalized healthcare regenerative medicine applications.

Язык: Английский

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Versatility of electrospun Janus wound dressings

Nanomedicine, Год журнала: 2024, Номер 20(3), С. 271 - 278

Опубликована: Дек. 23, 2024

Electrospun nanofibers produced through single-fluid blending processes have successfully demonstrated their potential as highly effective wound dressings. However, electrospun Janus nanofibers, in which various chambers can be designed to load different active pharmaceutical ingredients into polymeric matrices, are further exhibiting versatility for promoting healing. This commentary declares that dressings always need multiple functional performances promote unique advantages, with parts interacting environments, thereby providing a versatile platform developing novel Two recent examples, each preparation strategy dressings, discussed, and the promising future of dressing applications is highlighted.

Язык: Английский

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Multi-functional Dressings for Recovery and Screenable Treatment of Wounds: A review

Heliyon, Год журнала: 2024, Номер 11(1), С. e41465 - e41465

Опубликована: Дек. 24, 2024

Язык: Английский

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Leukocyte Platelet‐Rich Plasma‐Derived Exosomes Restrained Macrophages Viability and Induced Apoptosis, NO Generation, and M1 Polarization

Immunity Inflammation and Disease, Год журнала: 2024, Номер 12(11)

Опубликована: Ноя. 1, 2024

ABSTRACT Background Chronic refractory wounds refer to that cannot be repaired timely. Platelet‐rich plasma (PRP) has significant potential in chronic wound healing therapy. The exosomes isolated from PRP were proved exhibit more effectiveness than PRP. However, the therapeutic of on remained elusive. Hence, this study aimed clarify action by evaluating response macrophages exosomes. Methods Pure platelet‐rich (P‐PRP) and leukocyte (L‐PRP) prepared fasting venous blood healthy volunteers. Exosomes extracted P‐PRP L‐PRP using ultracentrifugation identified transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA), western blot. Macrophages obtained inducing THP‐1 cells with phorbol‐12‐myristate‐13 acetate (PMA). internalization into was observed utilizing confocal laser scanning after being labeled PKH67. Cell viability determined CCK‐8 assay. apoptosis measured a flow cytometer. polarization status M1 M2 evaluated detecting their markers. Nitric oxide (NO) detection conducted commercial kit. Results absorbed macrophages. restrained induced Besides, promoted polarization, polarization. Furthermore, NO generation Conclusion viability, macrophages, while increased presented effective effect P‐PRP, making it promising strategy for management.

Язык: Английский

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Therapeutic Properties of M2 Macrophages in Chronic Wounds: An Innovative Area of Biomaterial-Assisted M2 Macrophage Targeted Therapy

Stem Cell Reviews and Reports, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 18, 2024

Язык: Английский

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