The Comprehensive Review: Exploring Future Potential of Nasopulmonary Drug Delivery Systems for Nasal Route Drug Administration
Journal of Drug Delivery and Therapeutics,
Год журнала:
2024,
Номер
14(3), С. 126 - 136
Опубликована: Март 15, 2024
This
comprehensive
review
aims
to
explore
the
future
potential
of
nasopulmonary
drug
delivery
systems
for
administration
drugs
through
nasal
route.
Nasal
has
gained
significant
attention
due
its
numerous
advantages,
including
rapid
absorption,
avoidance
first-pass
metabolism,
and
non-invasive
administration.
provides
an
overview
anatomy
physiology,
highlighting
factors
influencing
absorption
bioavailability.
Additionally,
it
discusses
various
types
systems,
such
as
sprays,
powders,
gels,
along
with
their
advantages
limitations.
Furthermore,
delves
into
challenges
associated
delivery,
mucociliary
clearance,
irritation,
formulation
issues.
The
applications
in
treatment
diseases,
allergies,
respiratory
disorders,
systemic
conditions,
are
also
discussed.
Finally,
concludes
outlook
on
prospects
emphasising
need
further
research
development
optimise
efficacy
safety.
Keywords:
pulmonary;
spray;
mucosa;
gels;
drops;
approaches;
route;
delivery.
Язык: Английский
An Updated Comprehensive Review on Novel Drug Delivery Systems (NDDS) In the Pharmaceuticals
Asian Journal of Pharmaceutical Research and Development,
Год журнала:
2024,
Номер
12(1), С. 55 - 64
Опубликована: Фев. 15, 2024
The
field
of
pharmaceutical
sciences
has
witnessed
a
paradigm
shift
with
the
advent
Novel
Drug
Delivery
Systems
(NDDS),
which
aim
to
enhance
therapeutic
efficacy,
reduce
side
effects,
and
improve
patient
compliance.
This
comprehensive
review
explores
latest
advancements
innovations
in
NDDS,
encompassing
diverse
range
delivery
platforms
strategies.(NDDs
are
transforming
landscape
treatment,
offering
unparalleled
potential
for
enhanced
improved
bioavailability,
controlled
release,
targeted
delivery,
stability.
highlighting
recent
addressing
key
challenges.
Prominent
NDDS
include
liposomes,
nanoparticles,
micelles,
polymeric
drug
conjugates,
monoclonal
antibodies,
implants,
patches.
Each
system
possesses
unique
properties
applications,
tailored
specific
drugs
needs.
Recent
breakthroughs
nanocarriers,
gene
therapy
vectors,
3D-printed
personalized
dosage
forms
pushing
boundaries
innovation.
main
highlights
present
firstly
basics
on
NDDs,
several
approaches
nano
carriers
their
preparation
methods
example.
middle
version
discuss
techniques
NDDs
lastly
marketed
formulation
particular
carrier.
Язык: Английский
Nanoparticles (NPs) Based Drug Delivery System: An Inspiring Therapeutic Strategy for Cancer Therapy and Their Future Prospects
I. Dutta,
Atibur Rahaman,
S.D. Singh
и другие.
Journal of Drug Delivery and Therapeutics,
Год журнала:
2025,
Номер
15(4), С. 133 - 143
Опубликована: Апрель 15, 2025
Nanoparticles
(NPs)-based
drug
delivery
systems
(DDs)
have
emerged
as
a
promising
strategy
for
cancer
therapy,
offering
targeted,
controlled,
and
efficient
while
minimizing
systemic
toxicity.
Their
unique
physicochemical
properties,
including
high
surface
area,
tunable
size,
enhanced
permeability,
enable
precise
tumor
targeting
through
passive,
active,
stimuli-responsive
mechanisms.
The
various
nanocarriers
such
liposomes,
polymeric
NPs,
dendrimers,
metallic
NPs
been
extensively
explored
chemotherapy,
gene
immunotherapy,
theranostic
applications.
ability
of
to
overcome
multidrug
resistance
(MDR),
enhance
bioavailability,
facilitate
combination
therapies
has
significantly
improved
treatment
outcomes.
Despite
the
remarkable
advancements,
challenges
biocompatibility,
large-scale
production,
regulatory
approval
remain
critical
hurdles.
Future
research
will
focus
on
personalized
nanomedicine,
smart
multifunctional
nanocarriers,
gene-editing
nanoparticle
systems,
green
nanotechnology
safer
more
effective
treatments.
continuous
evolution
in
therapy
holds
immense
potential
transform
oncology,
paving
way
patient-specific,
minimally
invasive,
highly
modalities.
This
review
article
focuses
lipid-based,
polymeric,
inorganic
nanoparticles
system
their
applications
therapy.
current
limitations
future
perspectives
nanoparticle-based
DDS
are
also
discussed.
Keywords:
Drug
delivery,
Nanocarriers,
NDDS,
Sustained,
Targeted
Язык: Английский
A Traditional Review: The Utilization of Nutraceutical as a Traditional Cure for the Modern World at Current Prospectus for Multiple Health Conditions
Journal of Drug Delivery and Therapeutics,
Год журнала:
2024,
Номер
14(3), С. 154 - 163
Опубликована: Март 15, 2024
Nutraceuticals
refer
to
food
products
that
have
a
positive
impact
on
the
well-being
of
individuals.
This
category
includes
dietary
supplements,
herbal
products,
probiotics,
and
prebiotics,
as
well
medical
foods
designed
for
disease
prevention
treatment.
The
nutraceutical
market
is
witnessing
substantial
growth
worldwide,
primarily
due
growing
awareness
among
consumers
about
connection
between
diet
health.
Additionally,
there
rising
demand
functional
supplements.
As
prioritize
preventive
healthcare,
they
are
increasingly
looking
provide
targeted
health
benefits
beyond
basic
nutrition.
rise
this
trend
can
be
attributed
various
factors,
including
aging
population,
healthcare
expenses,
preference
natural
organic
ingredients.
Nutraceuticals,
major
force
in
industry,
offer
numerous
beneficial
effects
with
minimal
undesirable
impacts,
thus
attracting
more
consumer
interest.
increasing
shift
towards
treatments,
along
disposable
income
outlook
pharmaceutical
sector,
has
contributed
expanding
India.
However,
challenges
such
lack
regulation
awareness,
high
pricing,
marketing,
distribution
issues
need
addressed.
Nutraceutical
seeing
flowing
development
chiefly
United
States,
India,
European
nations.
review
article
focuses
providing
concise
overview
nutraceuticals,
categorizing
them,
discussing
their
significant
roles
conditions.
it
delves
into
present
future
status
nutraceuticals
global
scale.
Keywords:
traditional
cure;
nutraceuticals;
remedy;
prebiotics;
probiotics;
regulatory
compliance;
supplementary
diets;
Язык: Английский
The diverse marketed formulations of advanced nano drug carrier vehicles (and CVS) in different biomedical treatments: a complete descriptive review
Deleted Journal,
Год журнала:
2024,
Номер
15(2), С. 1 - 18
Опубликована: Апрель 30, 2024
The
field
of
pharmaceutical
science
and
drug
delivery
has
seen
a
remarkable
transformation
in
recent
years,
marked
by
the
emergence
diverse
advanced
approaches
development
Novel
Drug
Delivery
Systems
(NDDs)
their
associated
carriers.Nanocarriers
are
tiny
particles
that
can
be
used
to
deliver
drugs
body.They
typically
less
than
100
nanometres
diameter,
which
is
about
1,000
times
smaller
width
human
hair.NDDs
play
pivotal
role
enhancing
therapeutic
efficacy,
safety,
patient
compliance
pharmaceuticals.The
research
community
increasingly
focused
on
creating
novel
systems
address
limitations
conventional
administration
methods.The
diversification
these
notable,
reflecting
interdisciplinary
nature
sciences.NDDs
specific
sites
body,
control
rate
release,
protect
from
degradation.Carriers
an
important
NDDs.The
main
highlights
review
articles
focus
nano
carriers
including
niosome,
liposome,
aquasome,
nanoparticles
(NPs)
phytosomes
with
marketed
available
different
products
specified
disease
targeting.1.
Язык: Английский
The Comprehensive Review: Internet Protocol (IP) Address a Primer for Digital Connectivity
Mayank Kumar Tiwari,
Rahul Pal,
Riya Singh
и другие.
Asian Journal of Research in Computer Science,
Год журнала:
2024,
Номер
17(8), С. 34 - 45
Опубликована: Июль 16, 2024
The
Internet
Protocol
(IP)
is
the
rule
book
that
governs
how
data
addressed
and
routed
across
networks
on
internet.
Think
of
it
as
postal
system
for
digital
world.
This
addressing
allows
routers,
mail
carriers,
to
efficiently
transfer
packets
between
devices
until
they
reach
their
destination.
It
ensures
reaches
right
place
by
assigning
addresses
enabling
efficient
routing.
IP
also
encompasses
various
protocols
services,
such
ICMP
(Internet
Control
Message
Protocol)
error
reporting
diagnostics,
DHCP
(Dynamic
Host
Configuration
automatic
address
assignment.
Additionally,
can
be
configured
support
different
transmission
modes,
including
uni-cast,
multicast,
broadcast,
catering
diverse
communication
requirements.
Adopting
technology
has
been
researched
developed
commercially
offers
military
a
cost-effective
method
implementation.
systems
enable
forces
share
common
network
supports
voice,
video,
sharing.
systematic
review
article
initially
highlighted
basics
lastly
brief
discussion
regards
gram
format,
NAT,
IPv4,
IPV6
fragmentation,
CIDR,
TCP
UDP
individually.
Язык: Английский
Coating Tablets, Compositions, Recent Advancement and Current Status: A Comprehensive Review
Raj Kumar Mandal,
Paarth Saini,
Rahul Pal
и другие.
Journal of Drug Delivery and Therapeutics,
Год журнала:
2024,
Номер
14(10), С. 182 - 195
Опубликована: Окт. 15, 2024
Conventional
Tablets
are
solid
oral
dosage
forms
that
contain
an
active
pharmaceutical
ingredient
(API)
along
with
excipients.
These
tablets
typically
prepared
through
direct
compression,
wet
granulation,
or
dry
granulation.
They
designed
to
disintegrate
and
release
the
API
in
a
controlled
immediate
manner,
depending
on
formulation.
Tablet
coating
is
vital
process
technology,
improve
therapeutic
efficacy,
patient
compliance,
stability
of
forms.
This
comprehensive
review
explores
key
aspects
tablet
coating,
including
types,
compositions,
recent
advancements.
Coating
materials
such
as
polymers,
plasticizers,
pigments
discussed
detail,
their
roles
controlling
drug
release,
masking
taste,
enhancing
aesthetic
appeal.
The
advancements
focus
innovative
techniques
like
film
coatings,
enteric
application
nanotechnology
precision
functionality.
Additionally,
current
status
analyzed
terms
regulatory
compliance
industry
trends.
highlights
future
potential
personalized
smart
environmentally
friendly
approaches,
showcasing
evolving
landscape
technologies/pans
modern
manufacturing
development.
Keywords:
Table
coating;
form;
enteric;
pans;
formulation;
advancement;
polymers
Язык: Английский
The Application of Response Surface Methodology (RSM) In the Computational Optimization of Sustained Release (SR) For Phenothiazine Derivative Matrix Tablet
Journal of Pharmaceutical Research International,
Год журнала:
2023,
Номер
35(35), С. 13 - 27
Опубликована: Дек. 28, 2023
Introduction:
This
study
explores
the
use
of
Response
Surface
Methodology
(RSM),
a
statistical
optimization
technique,
to
optimize
SR
properties
prochlorperazine
maleate
(PCM)
matrix
tablets.
PCM
is
phenothiazine
derivative
used
for
treating
schizophrenia,
nausea,
and
vomiting.
Sustained-release
formulations
offer
extended
drug
delivery,
potentially
improving
patient
compliance
reducing
side
effects.
RSM
helps
identify
optimal
combinations
critical
formulation
factors
influencing
release,
such
as
polymer
type
concentration,
filler
type,
drug/polymer
ratio.
The
likely
involves
designing
experiments
based
on
chosen
designs
(e.g.,
Box-Behnken)
with
varying
factor
levels.
Formulate
tablets
different
combinations.
Evaluating
release
profiles
each
tablet
formulation.
Analyzing
data
using
software
build
mathematical
models
relating
identifying
that
maximize
desired
characteristics.
Objective:
ongoing
research
purpose
improve
advancement
sustained
containing
Phenothiazine
loaded
matrix.
achieved
by
utilizing
DoE
computational
method
statistically
validate
Methodology:
Basically
two
methods
involved
in
direct
compression;
simple
efficient
where
all
dry
ingredients
are
blended
directly
compressed
into
Results:
obtained
outcomes
closely
matched
anticipated
values
derived
from
experimental
setup.
enhanced
demonstrated
prolonged
uniform
discharge
over
span
6
hours.
Conclusion:
Based
23
FD,
response
surface
methodology
was
successfully
develop
current
application.
corresponding
contour
plots
3D
represent
important
variables
optimisation
process.
Язык: Английский