Circadian clock control of endocrine factors

Nature Reviews Endocrinology, Год журнала: 2014, Номер 10(8), С. 466 - 475

Опубликована: Май 27, 2014

Язык: Английский

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Influence of sleep deprivation and circadian misalignment on cortisol, inflammatory markers, and cytokine balance

Brain Behavior and Immunity, Год журнала: 2015, Номер 47, С. 24 - 34

Опубликована: Янв. 29, 2015

Язык: Английский

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The Functional and Clinical Significance of the 24-Hour Rhythm of Circulating Glucocorticoids

Endocrine Reviews, Год журнала: 2016, Номер 38(1), С. 3 - 45

Опубликована: Окт. 17, 2016

Abstract Adrenal glucocorticoids are major modulators of multiple functions, including energy metabolism, stress responses, immunity, and cognition. The endogenous secretion is normally characterized by a prominent robust circadian (around 24 hours) oscillation, with daily peak around the time habitual sleep-wake transition minimal levels in evening early part night. It has long been recognized that this 24-hour rhythm partly reflects activity master pacemaker located suprachiasmatic nucleus hypothalamus. In past decade, secondary clocks based on same molecular machinery as central were found other brain areas well most peripheral tissues, adrenal glands. Evidence rapidly accumulating to indicate misalignment between host adverse effects. circulating glucocorticoid internal synchronizer system. present review examines scientific foundation these novel advances their implications for health disease prevention treatment.

Язык: Английский

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Metabolic Consequences of Sleep and Circadian Disorders

Current Diabetes Reports, Год журнала: 2014, Номер 14(7)

Опубликована: Май 9, 2014

Язык: Английский

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Sleep influences on obesity, insulin resistance, and risk of type 2 diabetes

Metabolism, Год журнала: 2018, Номер 84, С. 56 - 66

Опубликована: Март 3, 2018

Язык: Английский

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Endogenous circadian system and circadian misalignment impact glucose tolerance via separate mechanisms in humans

Proceedings of the National Academy of Sciences, Год журнала: 2015, Номер 112(17)

Опубликована: Апрель 13, 2015

Glucose tolerance is lower in the evening and at night than morning. However, relative contribution of circadian system vs. behavioral cycle (including sleep/wake fasting/feeding cycles) unclear. Furthermore, although shift work a diabetes risk factor, separate impact on glucose cycle, phase, disruption (i.e., misalignment between central pacemaker cycle) has not been systematically studied. Here we show--by using two 8-d laboratory protocols--in healthy adults that have distinct influences tolerance, both from cycle. First, postprandial was 17% higher tolerance) biological (8:00 PM) morning AM; i.e., phase effect), independent effect. Second, itself (12-h inversion) increased by 6%. Third, these variations appeared to be explained, least part, different mechanisms: during decreased pancreatic β-cell function (27% early-phase insulin) presumably insulin sensitivity (elevated despite 14% late-phase without change insulin. We explored possible contributing factors, including changes polysomnographic sleep 24-h hormonal profiles. demonstrate importantly contributes reduced observed compared with Separately, reduces providing mechanism help explain workers.

Язык: Английский

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Role of the circadian system in cardiovascular disease

Journal of Clinical Investigation, Год журнала: 2018, Номер 128(6), С. 2157 - 2167

Опубликована: Май 31, 2018

All species organize behaviors to optimally match daily changes in the environment, leading pronounced activity/rest cycles that track light/dark cycle. Endogenous, approximately 24-hour circadian rhythms brain, autonomic nervous system, heart, and vasculature prepare cardiovascular system for optimal function during these anticipated behavioral cycles. Cardiovascular rhythms, however, may be a double-edged sword. The normal amplified responses morning aid transition from sleep activity, but such exaggerated are potentially perilous individuals susceptible adverse events. Indeed, occurrence of stroke, myocardial infarction, sudden cardiac death all have patterns, striking most frequently morning. Furthermore, chronic disruptions clock, as with night-shift work, contribute increased risk. Here we highlight importance disease, identify opportunities optimizing timing medications disease.

Язык: Английский

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The circadian regulation of food intake

Nature Reviews Endocrinology, Год журнала: 2019, Номер 15(7), С. 393 - 405

Опубликована: Май 9, 2019

Язык: Английский

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Health consequences of electric lighting practices in the modern world: A report on the National Toxicology Program's workshop on shift work at night, artificial light at night, and circadian disruption

The Science of The Total Environment, Год журнала: 2017, Номер 607-608, С. 1073 - 1084

Опубликована: Июль 27, 2017

Язык: Английский

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LEDs for photons, physiology and food

Nature, Год журнала: 2018, Номер 563(7732), С. 493 - 500

Опубликована: Ноя. 1, 2018

Язык: Английский

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