European Heart Journal,
Год журнала:
2021,
Номер
42(40), С. 4180 - 4188
Опубликована: Июль 16, 2021
The
aim
of
this
study
was
to
test
whether
current
and
past
night
shift
work
associated
with
incident
atrial
fibrillation
(AF)
association
modified
by
genetic
vulnerability.
Its
associations
coronary
heart
disease
(CHD),
stroke,
failure
(HF)
were
measured
as
a
secondary
aim.This
cohort
included
283
657
participants
in
paid
employment
or
self-employed
without
AF
276
009
free
CHD,
HF
at
baseline
the
UK
Biobank.
Current
lifetime
information
obtained.
Cox
proportional
hazard
models
used.
Weighted
risk
score
for
calculated.
During
median
follow-up
10.4
years,
5777
cases
documented.
From
'day
workers',
'shift
but
never/rarely
shifts',
'some
shifts'
'usual/permanent
there
significant
increasing
trend
(P
0.013).
Usual
permanent
shifts
highest
[hazard
ratio
(HR)
1.16,
95%
confidence
interval
(CI)
1.02-1.32].
Considering
person's
schedule
compared
workers
never
working
nights,
duration
over
10
years
an
average
3-8
nights/month
frequency
exposure
possessed
higher
(HR
1.18,
CI
0.99-1.40
HR
1.22,
1.02-1.45,
respectively).
These
between
not
predisposition
AF.
Usual/permanent
shifts,
≥10
significantly
CHD
1.11-1.35,
1.37,
1.20-1.58
1.35,
1.18-1.55,
stroke
significant.Both
exposures
increased
risk,
regardless
risk.
Night
also
HF.
Whether
decreasing
might
represent
another
avenue
improve
health
during
life
beyond
warrants
further
study.
Journal of sport and health science/Journal of Sport and Health Science,
Год журнала:
2022,
Номер
12(1), С. 8 - 35
Опубликована: Окт. 29, 2022
Exercise
has
long
been
known
for
its
active
role
in
improving
physical
fitness
and
sustaining
health.
Regular
moderate-intensity
exercise
improves
all
aspects
of
human
health
is
widely
accepted
as
a
preventative
therapeutic
strategy
various
diseases.
It
well-documented
that
maintains
restores
homeostasis
at
the
organismal,
tissue,
cellular,
molecular
levels
to
stimulate
positive
physiological
adaptations
consequently
protect
against
pathological
conditions.
Here
we
mainly
summarize
how
affects
major
hallmarks
health,
including
integrity
barriers,
containment
local
perturbations,
recycling
turnover,
integration
circuitries,
rhythmic
oscillations,
homeostatic
resilience,
hormetic
regulation,
well
repair
regeneration.
Furthermore,
current
understanding
mechanisms
responsible
beneficial
response
exercise.
This
review
aimed
providing
comprehensive
summary
vital
biological
through
which
opens
window
application
other
interventions.
We
hope
continuing
investigation
this
field
will
further
increase
our
processes
involved
thus
get
us
closer
identification
new
therapeutics
improve
quality
life.
PLoS Medicine,
Год журнала:
2021,
Номер
18(8), С. e1003767 - e1003767
Опубликована: Авг. 30, 2021
Background
Air
pollution
has
been
related
to
incidence
of
type
2
diabetes
(T2D).
We
assessed
the
joint
association
various
air
pollutants
with
risk
T2D
and
examined
potential
modification
by
obesity
status
genetic
susceptibility
on
relationship.
Methods
findings
A
total
449,006
participants
from
UK
Biobank
free
at
baseline
were
included.
Of
all
study
population,
90.9%
white
45.7%
male.
The
had
a
mean
age
56.6
(SD
8.1)
years
old
body
mass
index
(BMI)
27.4
4.8)
kg/m
.
Ambient
pollutants,
including
particulate
matter
(PM)
diameters
≤2.5
μm
(PM
2.5
),
between
10
2.5–10
nitrogen
dioxide
(NO
nitric
oxide
(NO)
measured.
An
score
was
created
assess
exposure
4
pollutants.
During
median
11
follow-up,
we
documented
18,239
incident
cases.
significantly
associated
higher
T2D.
Compared
lowest
quintile
score,
hazard
ratio
(HR)
(95%
confidence
interval
[CI])
for
1.05
(0.99
1.10,
p
=
0.11),
1.06
(1.00
1.11,
0.051),
1.09
(1.03
1.15,
0.002),
1.12
(1.06
1.19,
<
0.001)
second
fifth
quintile,
respectively,
after
adjustment
sociodemographic
characteristics,
lifestyle
factors,
other
covariates.
In
addition,
found
significant
interaction
(
-interaction
0.001).
observed
more
pronounced
among
overweight
obese
than
in
normal-weight
people.
Genetic
(GRS)
or
did
not
modify
relationship
Key
limitations
include
unavailable
data
T2D-related
single-time
measurement
Conclusions
that
PM
,
NO
2,
NO,
individually
jointly,
an
increased
population.
stratified
analyses
indicate
such
associations
strongly
those
adiposity.
PLoS Medicine,
Год журнала:
2023,
Номер
20(1), С. e1004135 - e1004135
Опубликована: Янв. 10, 2023
Background
The
influence
of
overall
lifestyle
behaviors
on
diabetic
microvascular
complications
remains
unknown.
In
addition,
the
potential
mediating
biomarkers
underlying
association
is
unclear.
This
study
aimed
to
examine
associations
combined
factors
with
risks
total
and
individual
among
patients
type
2
diabetes
(T2D)
explore
mediation
effects
metabolic
biomarkers.
Methods
findings
retrospective
cohort
included
15,104
T2D
free
macro-
at
baseline
(2006
2010)
from
UK
Biobank.
Healthy
noncurrent
smoking,
recommended
waist
circumference,
regular
physical
activity,
healthy
diet,
moderate
alcohol
drinking.
Outcomes
were
ascertained
using
electronic
health
records.
Over
a
median
8.1
years
follow-up,
1,296
cases
composite
occurred,
including
558
retinopathy,
625
kidney
disease,
315
neuropathy,
some
having
or
3
simultaneously.
After
multivariable
adjustment
for
sociodemographic
characteristics,
history
hypertension,
glycemic
control,
medication
histories,
hazard
ratios
(95%
confidence
intervals
(CIs))
participants
adhering
4
5
low-risk
versus
0
1
0.65
(0.46,
0.91)
0.43
(0.30,
0.61)
0.46
(0.29,
0.74)
0.54
(0.43,
0.68)
outcome
(all
Ps
-trend
≤0.01).
Further,
population-attributable
fraction
CIs)
poor
adherence
(<4
factors)
ranged
25.3%
(10.0%,
39.4%)
39.0%
(17.7%,
56.8%).
albumin,
HDL-C,
triglycerides,
apolipoprotein
A,
C-reactive
protein,
HbA
1c
collectively
explained
23.20%
(12.70%,
38.50%)
between
complications.
key
limitation
current
analysis
was
underreporting
because
identified
via
Conclusions
Adherence
associated
significantly
lower
risk
in
T2D,
favorable
partially
mediated
through
improving
systemic
inflammation,
liver
function,
lipid
profile.
Diabetologia,
Год журнала:
2022,
Номер
65(10), С. 1710 - 1720
Опубликована: Июль 24, 2022
Time-restricted
eating
(TRE)
is
suggested
to
improve
metabolic
health
by
limiting
food
intake
a
defined
time
window,
thereby
prolonging
the
overnight
fast.
This
prolonged
fast
expected
lead
more
pronounced
depletion
of
hepatic
glycogen
stores
and
might
insulin
sensitivity
due
an
increased
need
replenish
nutrient
storage.
Previous
studies
showed
beneficial
effects
6-8
h
TRE
regimens
in
healthy,
overweight
adults
under
controlled
conditions.
However,
on
glucose
homeostasis
individuals
with
type
2
diabetes
are
unclear.
Here,
we
extensively
investigated
levels
diabetes.Fourteen
(BMI
30.5±4.2
kg/m2,
HbA1c
46.1±7.2
mmol/mol
[6.4±0.7%])
participated
3
week
(daily
within
10
h)
vs
control
(spreading
over
≥14
regimen
randomised,
crossover
trial
design.
The
study
was
performed
at
Maastricht
University,
Netherlands.
Eligibility
criteria
included
diagnosis
diabetes,
intermediate
chronotype
absence
medical
conditions
that
could
interfere
execution
and/or
outcome.
Randomisation
study-independent
investigator,
ensuring
equal
amount
participants
started
CON.
Due
nature
study,
neither
volunteers
nor
investigators
were
blinded
interventions.
quality
data
checked
without
knowledge
intervention
allocation.
Hepatic
assessed
13C-MRS
using
hyperinsulinaemic-euglycaemic
two-step
clamp.
Furthermore,
24
continuous
monitoring
devices.
Secondary
outcomes
energy
expenditure
substrate
oxidation,
lipid
content
skeletal
muscle
mitochondrial
capacity.Results
depicted
as
mean
±
SEM.
similar
between
condition
(0.15±0.01
0.15±0.01
AU,
p=0.88).
M
value
not
significantly
affected
(19.6±1.8
17.7±1.8
μmol
kg-1
min-1
control,
respectively,
p=0.10).
peripheral
also
remained
unaffected
(p=0.67
p=0.25,
respectively).
Yet,
insulin-induced
non-oxidative
disposal
(non-oxidative
4.3±1.1
1.5±1.7
min-1,
p=0.04).
spent
normoglycaemic
range
(15.1±0.8
12.2±1.1
per
day,
p=0.01),
decreased
fasting
(7.6±0.4
8.6±0.4
mmol/l,
p=0.03)
(6.8±0.2
7.6±0.3
p<0.01).
Energy
unaffected;
nevertheless,
oxidation
(260.2±7.6
277.8±10.7
g/day,
No
adverse
events
reported
related
interventions.We
show
feasible,
safe
effective
means
free-living
diabetes.
these
changes
accompanied
or
glycogen.ClinicalTrials.gov
NCT03992248
FUNDING:
ZonMW,
459001013.
Neuropsychopharmacology,
Год журнала:
2019,
Номер
45(1), С. 176 - 191
Опубликована: Июнь 11, 2019
The
military
lifestyle
often
includes
continuous
operations
whether
in
training
or
deployed
environments.
These
stressful
environments
present
unique
challenges
for
service
members
attempting
to
achieve
consolidated,
restorative
sleep.
significant
mental
and
physical
derangements
caused
by
degraded
metabolic,
cardiovascular,
skeletomuscular,
cognitive
health
result
from
insufficient
sleep
and/or
circadian
misalignment.
Insufficient
resulting
fatigue
compromises
personal
safety,
mission
success,
even
national
security.
In
the
long-term,
chronic
rhythm
disorders
have
been
associated
with
other
(e.g.,
insomnia,
obstructive
apnea,
parasomnias).
Other
physiologic
psychologic
diagnoses
such
as
post-traumatic
stress
disorder,
cardiovascular
disease,
dementia
also
chronic,
Increased
co-morbidity
mortality
are
compounded
traumatic
brain
injury
blunt
trauma,
blast
exposure,
highly
physically
demanding
tasks
under
load.
We
current
state
of
science
human
animal
models
specific
during-
post-military
career.
focus
on
requirements
night
shift
work,
sustained
operations,
rapid
re-entrainment
time
zones.
then
propose
targeted
pharmacological
non-pharmacological
countermeasures
optimize
performance
that
mission-
symptom-specific.
recognize
a
critical
gap
research
involving
members,
but
provide
tailored
interventions
care
providers
based
large
body
public
workers.
Chronobiology International,
Год журнала:
2019,
Номер
37(1), С. 29 - 46
Опубликована: Ноя. 4, 2019
To
evaluate
the
association
between
shift
work
and
risk
of
type
2
diabetes
mellitus,
we
searched
PubMed,
EMBASE
Web
Science
from
their
inception
to
June
8,
2019.
Observational
studies
examining
relationship
were
included.
Subgroup
analyses
conducted
explore
whether
specific
characteristics
would
affect
relationship.
A
dose-response
was
estimated
by
using
generalized
least
squares
trend
regression.
Finally,
twelve
cohort
nine
cross-sectional
included
(inter-rater
agreement,
k
=
0.96).
The
result
meta-analysis
indicated
that
associated
with
an
increased
(relative
1.10,
95%
confidence
interval
1.05–1.14).
demonstrated
female
workers
have
while
male
not
observed,
health
care
showed
highest
compared
civil
servants
manual
workers,
night
rotating
diabetes.
Dose-response
based
on
three
cohorts
among
there
might
be
a
positive
duration
In
conclusion,
is
positively
Among
years
exposure
prolonged,
increase
accordingly.
future,
more
are
needed
confirm
results
analysis.
FEBS Letters,
Год журнала:
2020,
Номер
594(17), С. 2734 - 2769
Опубликована: Авг. 4, 2020
The
circadian
system
is
composed
of
coupled
endogenous
oscillators
that
allow
living
beings,
including
humans,
to
anticipate
and
adapt
daily
changes
in
their
environment.
In
mammals,
clocks
form
a
hierarchically
organized
network
with
‘master
clock’
located
the
suprachiasmatic
nucleus
hypothalamus,
which
ensures
entrainment
subsidiary
environmental
cycles.
Robust
rhythmicity
body
indispensable
for
temporally
coordinating
organ
functions,
disruption
or
misalignment
rhythms
caused
instance
by
modern
lifestyle
strongly
associated
various
widespread
diseases.
This
review
aims
provide
comprehensive
overview
our
current
knowledge
about
molecular
architecture
system‐level
organization
mammalian
oscillators.
Furthermore,
we
discuss
regulatory
roles
peripheral
cell
physiology
implication
temporal
coordination
metabolism
human
health
disease.
Finally,
summarize
methods
assessing
humans.
