
Science Advances, Год журнала: 2021, Номер 7(49)
Опубликована: Дек. 3, 2021
Appropriate meal timing, despite mistimed sleep, maintains internal circadian alignment and prevents glucose intolerance.
Язык: Английский
Science Advances, Год журнала: 2021, Номер 7(49)
Опубликована: Дек. 3, 2021
Appropriate meal timing, despite mistimed sleep, maintains internal circadian alignment and prevents glucose intolerance.
Язык: Английский
Science Advances, Год журнала: 2021, Номер 7(43)
Опубликована: Окт. 21, 2021
Disturbances in daily rhythms of mitochondrial activity may contribute to skeletal muscle insulin resistance type 2 diabetes.
Язык: Английский
Процитировано
84Scandinavian Journal of Work Environment & Health, Год журнала: 2020, Номер 46(6), С. 557 - 569
Опубликована: Сен. 8, 2020
Objectives This discussion paper aims to provide scientifically based recommendations on night shift schedules, including consecutive shifts, intervals and duration of which may reduce health safety risks. Short-term physiological effects in terms circadian disruption, inadequate sleep quality, fatigue were considered as possible links between work selected risks, namely, cancer, cardio-metabolic disease, injuries, pregnancy-related outcomes. Method In early 2020, 15 experienced researchers participated a workshop where they identified relevant scientific literature within their main research area. Results Knowledge gaps discussed the current evidence. The consensus was that schedules disruption cancer risk, particularly for breast optimize occurrence injuries. is generally achieved with fewer sufficient intervals, shorter duration. Conclusions Based limited, existing literature, we recommend order risk injuries possibly have: (i) ≤3 shifts; (ii) ≥11 hours; (iii) ≤9 hours special cases – eg, oil rigs other isolated workplaces better possibilities adapt daytime additional or apply. Finally, miscarriage, pregnant women should not more than one week.
Язык: Английский
Процитировано
83Thorax, Год журнала: 2020, Номер 76(1), С. 53 - 60
Опубликована: Ноя. 16, 2020
Introduction Shift work causes misalignment between internal circadian time and the external light/dark cycle is associated with metabolic disorders cancer. Approximately 20% of working population in industrialised countries permanent or rotating night shifts, exposing this large to risk misalignment-driven disease. Analysis impact shift on chronic inflammatory diseases lacking. We investigated association asthma. Methods describe cross-sectional relationship prevalent asthma >280000 UK Biobank participants, making adjustments for major confounding factors (smoking history, ethnicity, socioeconomic status, physical activity, body mass index). also chronotype. Results Compared day workers, ‘permanent’ workers had a higher likelihood moderate-severe (OR 1.23 (95% CI 1.03 1.46)). Individuals doing any type adjusted odds wheeze/whistling chest. who never rarely worked nights people having reduced lung function (FEV 1 <80% predicted). found an increase individuals extreme chronotypes (morning, OR 1.55 1.06 2.27) evening, 1.31 (95%CI 1.22 1.40)). Conclusions The public health implications these findings are far-reaching due high prevalence co-occurrence both work. Future longitudinal follow-up studies needed determine if modifying schedules take into account chronotype might present measure reduce developing such as
Язык: Английский
Процитировано
79International Journal of Molecular Sciences, Год журнала: 2020, Номер 21(15), С. 5478 - 5478
Опубликована: Июль 31, 2020
The disruption of circadian rhythms by environmental conditions can induce alterations in body homeostasis, from behavior to metabolism. light:dark cycle is the most reliable agent, which entrains rhythms, although its credibility has decreased because extensive use artificial light at night. Light pollution compromise performance and health, but underlying mechanisms are not fully understood. present review assesses consequences induced constant (LL) comparison with dim night (dLAN) on control metabolism rodents, since such an approach identify key chronodisruption. Data suggest that effects LL more pronounced compared dLAN directly related level duration exposure. Dim LAN reduces nocturnal melatonin levels, similarly LL, corticosterone behavioral traits uniform improved quantification disrupted needed. Metabolism under strong lead various pathologies. Moreover, only output, some metabolites peripheral signal molecules feedback clockwork either stabilize or amplify desynchronization.
Язык: Английский
Процитировано
78Science Advances, Год журнала: 2021, Номер 7(49)
Опубликована: Дек. 3, 2021
Appropriate meal timing, despite mistimed sleep, maintains internal circadian alignment and prevents glucose intolerance.
Язык: Английский
Процитировано
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