Irregular sleep and cardiometabolic risk: Clinical evidence and mechanisms

Frontiers in Cardiovascular Medicine, Год журнала: 2023, Номер 10

Опубликована: Фев. 17, 2023

Sleep regularity is an essential part of the multidimensional sleep health framework. The phenomenon irregular patterns widespread in contemporary lifestyles. This review synthesizes clinical evidence to summarize measures and discusses role different indicators developing cardiometabolic diseases (coronary heart disease, hypertension, obesity, diabetes). Existing literature has proposed several measurements assess regularity, mainly including standard deviation (SD) duration timing, index (SRI), interdaily stability (IS), social jetlag (SJL). Evidence on associations between variability varies depending measure used characterize sleep. Current studies have identified a robust association SRI diseases. In comparison, other metrics was mixed. Meanwhile, with differ across population. SD characteristics or IS may be more consistently associated HbA1c patients diabetes compared general SJL hypertension for accordant than Interestingly, age-stratified metabolic factors observed present studies. Furthermore, relevant reviewed generalize potential mechanisms through which increases risk, circadian dysfunction, inflammation, autonomic hypothalamic–pituitary–adrenal (HPA) axis disorder, gut dysbiosis. Health-related practitioners should give attention human future.

Язык: Английский

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Sleep Duration Patterns in Early to Middle Adulthood and Subsequent Risk of Type 2 Diabetes in Women

Diabetes Care, Год журнала: 2020, Номер 43(6), С. 1219 - 1226

Опубликована: Март 24, 2020

To identify sleep duration trajectories from early to middle adulthood and their associations with incident type 2 diabetes.Using a group-based modeling approach, we identified based on in ages 20-25, 26-35, 36-45, 46+ years, which were retrospectively assessed 2009 among 60,068 women the Nurses' Health Study II (median age 54.9 years) who free of diabetes, cardiovascular disease, cancer. We investigated prospective between diabetes risk (2009-2017) using multivariable Cox proportional hazards models.We documented 1,797 cases over median follow-up 7.8 years (442,437 person-years). Six identified: persistent 5-, 6-, 7-, or 8-h increased decreased duration. After adjustment for factors, compared 7-h group, hazard ratio was 1.43 (95% CI 1.10, 1.84) 5-h 1.17 (1.04, 1.33) 6-h 0.96 (0.84, 1.10) 1.33 (1.09, 1.61) 1.32 (1.10, 1.59) group. Additional time-updated comorbidities BMI attenuated these associations, although significantly higher remained group (1.24 [1.03, 1.50]).Persistent short changes associated later life. These weaker after obesity metabolic accounted for.

Язык: Английский

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Association of Timing and Balance of Physical Activity and Rest/Sleep With Risk of COVID-19: A UK Biobank Study

Mayo Clinic Proceedings, Год журнала: 2020, Номер 96(1), С. 156 - 164

Опубликована: Окт. 31, 2020

Язык: Английский

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Access to Daylight at Home Improves Circadian Alignment, Sleep, and Mental Health in Healthy Adults: A Crossover Study

International Journal of Environmental Research and Public Health, Год журнала: 2021, Номер 18(19), С. 9980 - 9980

Опубликована: Сен. 23, 2021

As the primary environmental cue for body’s master biological clock, light–dark patterns are key circadian alignment and ultimately fundamental to multiple dimensions of health including sleep mental health. Although daylight provides proper qualities light promoting alignment, our modern indoor lifestyles offer fewer opportunities adequate exposure. This field study explores how increasing circadian-effective in residences affects phase, sleep, vitality, In this crossover study, 20 residents spent one week their apartments with electrochromic glass windows another functionally standard blinds. Calibrated sensors revealed higher daytime levels windows, participants exhibited consistent melatonin onset, a 22-min earlier regularity. blinds condition, 15-min delay dim subjective vitality throughout day, an overall lower positive affect. demonstrates impact lighting on physiological, behavioral, measures real-world environment stresses importance designing buildings that optimize human wellbeing.

Язык: Английский

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Variability in Daily Eating Patterns and Eating Jetlag Are Associated With Worsened Cardiometabolic Risk Profiles in the American Heart Association Go Red for Women Strategically Focused Research Network

Journal of the American Heart Association, Год журнала: 2021, Номер 10(18)

Опубликована: Сен. 6, 2021

Background Sleep variability and social jetlag are associated with adverse cardiometabolic outcomes via circadian disruption. Variable eating patterns also lead to disruption, but associations health unknown. Methods Results Women (n=115, mean age: 33±12 years) completed a 1-week food record using the Automated Self-Administered 24-Hour Dietary Assessment Tool at baseline 1 year. Timing of first last occasions, nightly fasting duration, %kcal consumed after 5 pm (%kcal pm) 8 were estimated. Day-to-day was assessed from SD these variables. Eating defined as weekday-weekend differences in metrics. Multivariable-adjusted linear models examined cross-sectional longitudinal day-to-day metrics risk. Greater start time, related higher body mass index waist circumference (P<0.05). In analyses, 10% increase predicted increased (β, 0.52; 95% CI, 0.23-0.81) 1.73; 0.58-2.87); greater 0.25; 0.07-0.43). Every 30-minute duration diastolic blood pressure 0.95; 0.40-1.50); an equivalent systolic 0.58; 0.11-1.05) 0.45; 0.10-0.80). Per SD, there 2.98 mm Hg (95% 0.04-5.92) 2.37mm 0.19-4.55) increases pressure; 1.83; 0.30-3.36). For hemoglobin A1c, every end time 0.09% 0.03-0.15), 0.06% 0.001-0.12), 0.23% 0.07-0.39) increases, respectively. Conclusions adiposity worse glycemic control. Findings warrant confirmation population-based cohorts intervention studies.

Язык: Английский

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