The
literature
paints
a
complex
picture
of
the
association
between
mortality
risk
and
ICU
strain.
In
this
study,
we
sought
to
determine
if
there
is
an
in
intensive
care
units
(ICU)
occupancy
beds
compatible
with
mechanical
ventilation,
as
proxy
for
strain.A
national
retrospective
observational
cohort
study
89
English
hospital
trusts
(i.e.
groups
hospitals
functioning
single
operational
units).
Seven
thousand
one
hundred
thirty-three
adults
admitted
England
2
April
1
December,
2020
(inclusive),
presumed
or
confirmed
COVID-19,
whom
data
was
submitted
surveillance
programme
met
inclusion
criteria.
A
Bayesian
hierarchical
approach
used
model
trust
level
(mechanical
ventilation
compatible),
bed
occupancy,
in-hospital
all-cause
mortality.
Results
were
adjusted
unit
characteristics
(pre-pandemic
size),
individual
patient-level
demographic
(age,
sex,
ethnicity,
deprivation
index,
time-to-ICU
admission),
recorded
chronic
comorbidities
(obesity,
diabetes,
respiratory
disease,
liver
heart
hypertension,
immunosuppression,
neurological
renal
disease).One
thirty-five
six
patient
days
observed,
rate
19.4
per
1000
days.
Adjusting
factors,
higher
admissions
during
periods
high
(>
85%
versus
baseline
45
85%)
[OR
1.23
(95%
posterior
credible
interval
(PCI):
1.08
1.39)].
contrast,
decreased
low
(<
45%
relative
baseline)
0.83
PCI
0.75
0.94)].Increasing
strain,
associated
individuals
ICU.
Further
research
required
establish
causal
relationship
whether
it
reflects
strain
on
other
factors
such
staff.
If
causal,
result
highlights
importance
strategies
keep
mitigate
impact
type
resource
saturation.
Experimental and Therapeutic Medicine,
Год журнала:
2022,
Номер
23(5)
Опубликована: Март 11, 2022
Diabetic
retinopathy
(DR)
is
a
microvascular
disorder
occurring
due
to
the
long-term
effects
of
diabetes,
leading
vision-threatening
damage
retina.
The
human
body
has
an
elaborate
system
for
managing
and
regulating
number
key
trace
metals
circulating
in
blood
stored
cells.
Inadequate
zinc
(Zn)
concurrent
excess
copper
(Cu)
levels
are
associated
with
increased
level
oxidative
stress,
which
may
aggravate
lesions
diabetes
mellitus.
Several
studies
have
revealed
significantly
lower
serum
Zn
concentration
Cu
DR
when
compared
diabetic
patients
without
normal
controls.
These
abnormalities
correlated
duration
higher
HbA1C.
Multiple
pathological
mechanisms
proposed
explain
these
changes
including
hyperzincuria
polyuria,
glycosuria,
proteinuria
patients,
as
well
impaired
absorption
at
gastrointestinal
level.
Increased
free
ions
be
attributed
glycation
release
from
Cu-binding
sites
proteins.
supplements
selective
chelators
useful
alleviate
stress
prevent
progression.
Journal of International Migration and Integration / Revue de l integration et de la migration internationale,
Год журнала:
2023,
Номер
24(3), С. 1305 - 1335
Опубликована: Янв. 11, 2023
Abstract
The
Covid-19
pandemic
has
had
a
major
impact
on
migrants
and
ethnic
minorities
(MEMs).
Socio-economic
factors
legal,
administrative
language
barriers
are
among
the
reasons
for
this
increased
susceptibility.
aim
of
study
is
to
investigate
MEMs
compared
general
population
in
terms
serious
outcomes.
We
conducted
systematic
review
collecting
studies
WHO
European
Region
regarding
hospitalisation,
intensive
care
unit
(ICU)
admission
mortality,
published
between
01/01/2020
19/03/2021.
Nine
researchers
were
involved
selection,
quality
assessment
data
extraction.
Of
82
included,
15
16
hospitalisation
reported
an
risk
white
and/or
native
22
out
28
focusing
ICU
rates
found
MEMs.
Among
65
43
report
higher
An
adverse
outcomes
was
Social
determinants
health
main
genesis
inequalities:
disadvantaged
socio-economic
status,
framework
structural
racism
asymmetric
access
healthcare
linked
susceptibility
consequences
Covid-19.
These
findings
underline
need
policymakers
consider
when
designing
prevention
plans.
Frontiers in Genetics,
Год журнала:
2024,
Номер
15
Опубликована: Сен. 4, 2024
This
study
investigated
the
influence
of
single
nucleotide
polymorphisms
(SNPs)
in
genes
associated
with
interferon
pathway
(IFNAR2
rs2236757),
antiviral
response
(OAS1
rs10774671,
OAS3
rs10735079),
and
viral
entry
(ACE2
rs2074192)
on
COVID-19
severity
their
association
nonalcoholic
fatty
liver
disease
(MAFLD).
We
did
not
observe
a
significant
between
SNPs
severity.
While
IFNAR2
rs2236757
A
allele
was
correlated
higher
creatinine
levels
upon
admission
G
lower
band
neutrophils
discharge,
these
findings
require
further
investigation.
The
distribution
OAS
gene
(rs10774671
rs10735079)
differ
MAFLD
patients
non-MAFLD
patients.
Our
population's
ACE2
rs2074192
genotypes
alleles
differed
from
that
European
reference
population.
Overall,
our
suggest
specific
may
be
major
contributors
to
patient
population,
highlighting
potential
role
other
genetic
factors
environmental
influences.
