The golden era of scientific publishing in China

动物学研究, Год журнала: 2025, Номер 46(1), С. 1 - 2

Опубликована: Янв. 1, 2025

The golden era of scientific publishing in ChinaIn Chinese culture, the dragon symbolizes faith, strength, courage, and an air mystery.In 2024, guided by this auspicious

Язык: Английский

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Co-Conservation of Synaptic Gene Expression and Circuitry in Collicular Neurons

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Янв. 23, 2025

The superior colliculus (SC), a midbrain sensorimotor hub, is anatomically and functionally similar across vertebrates, but how its cell types have evolved unclear. Using single-nucleus transcriptomics, we compared the SC's molecular cellular organization in mice, tree shrews, humans. Despite over 96 million years of evolutionary divergence, identified ∼30 consensus neuronal subtypes, including Cbln2 + neurons that form SC-pulvinar circuit mice shrews. Synapse-related genes were among most conserved, unlike neocortex, suggesting co-conservation synaptic circuitry. In contrast, cilia-related diverged significantly species, highlighting potential importance primary cilium SC evolution. Additionally, novel inhibitory neuron shrews humans not mice. Our findings reveal has by conserving genes, circuitry, while diversifying ciliary gene expression an subtype.

Язык: Английский

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Deciphering enhancers of hearing loss genes for efficient and targeted gene therapy of hereditary deafness

Neuron, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

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The tree shrew model of Parkinson’s disease: A cost-effective alternative to non-human primate models

Laboratory Investigation, Год журнала: 2024, Номер 104(11), С. 102145 - 102145

Опубликована: Сен. 27, 2024

Язык: Английский

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