The golden era of scientific publishing in China

动物学研究, Journal Year: 2025, Volume and Issue: 46(1), P. 1 - 2

Published: Jan. 1, 2025

The golden era of scientific publishing in ChinaIn Chinese culture, the dragon symbolizes faith, strength, courage, and an air mystery.In 2024, guided by this auspicious

Language: Английский

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Co-Conservation of Synaptic Gene Expression and Circuitry in Collicular Neurons

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

The superior colliculus (SC), a midbrain sensorimotor hub, is anatomically and functionally similar across vertebrates, but how its cell types have evolved unclear. Using single-nucleus transcriptomics, we compared the SC's molecular cellular organization in mice, tree shrews, humans. Despite over 96 million years of evolutionary divergence, identified ∼30 consensus neuronal subtypes, including Cbln2 + neurons that form SC-pulvinar circuit mice shrews. Synapse-related genes were among most conserved, unlike neocortex, suggesting co-conservation synaptic circuitry. In contrast, cilia-related diverged significantly species, highlighting potential importance primary cilium SC evolution. Additionally, novel inhibitory neuron shrews humans not mice. Our findings reveal has by conserving genes, circuitry, while diversifying ciliary gene expression an subtype.

Language: Английский

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Deciphering enhancers of hearing loss genes for efficient and targeted gene therapy of hereditary deafness

Neuron, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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The tree shrew model of Parkinson’s disease: A cost-effective alternative to non-human primate models

Laboratory Investigation, Journal Year: 2024, Volume and Issue: 104(11), P. 102145 - 102145

Published: Sept. 27, 2024

Language: Английский

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