Diffusion Tensor Imaging Along Perivascular Spaces (DTI-ALPS) to Assess Effects of Age, Sex, and Head Size on Interstitial Fluid Dynamics in Healthy Subjects

Journal of Alzheimer s Disease Reports, Год журнала: 2024, Номер 8(1), С. 355 - 361

Опубликована: Фев. 20, 2024

Diffusion tensor imaging along perivascular spaces (DTI-ALPS) is a novel MRI method for assessing brain interstitial fluid dynamics, potentially indexing glymphatic function. Failed clearance implicated in Alzheimer’s disease (AD) pathophysiology. We assessed the contribution of age and female sex (strong AD risk factors) to DTI-ALPS index healthy subjects. also first time effect head size. In accord with prior studies, we show reduced aging, men compared women. However, size may be major contributing factor this counterintuitive difference.

Язык: Английский

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Cannabidiol Alleviates Neurological Deficits After Traumatic Brain Injury by Improving Intracranial Lymphatic Drainage

Journal of Neurotrauma, Год журнала: 2024, Номер 41(15-16), С. e2009 - e2025

Опубликована: Март 30, 2024

Traumatic brain injury (TBI) persists as a substantial clinical dilemma, largely because of the absence effective treatments. This challenge is exacerbated by hindered clearance intracranial metabolic byproducts and continual accrual deleterious proteins. The glymphatic system (GS) meningeal lymphatic vessels (MLVs), key elements network, play critical roles in harmful substances. Cannabidiol (CBD) has shown promise reducing metabolite overload bolstering cognitive performance various neurodegenerative diseases. precise mechanisms attributing to its beneficial effects TBI scenarios, however, are yet be distinctly understood. Utilizing fluid percussion paradigm, our research adopted multifaceted approach, encompassing behavioral testing, immunofluorescence immunohistochemical analyses, laser speckle imaging, western blot techniques, bilateral cervical efferent ligation. methodology aimed discern influence CBD on both neurological outcomes murine model. We observed that administration notably ameliorated motor, memory, functions, concurrently with significant reduction concentration phosphorylated tau protein amyloid-β. In addition, expedited turnover elimination tracers, increased cerebral blood flow, enhanced efficacy fluorescent tracer migration from MLVs deep lymph nodes (dCLNs). Remarkably, treatment also induced reversion aquaporin-4 (AQP-4) polarization curtailed neuroinflammatory indices. A pivotal discovery was surgical interruption conduits neck nullified CBD's positive contributions waste disposal improvement, anti-neuroinflammatory actions remained unaffected. These insights suggest may enhance clearance, potentially via regulation system, thereby offering neurofunctional prognostic improvement models. Our findings underscore potential therapeutic applicability interventions, necessitating further comprehensive investigations validations substantiate these initial conclusions.

Язык: Английский

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Interstitial Fluidopathy of the Central Nervous System: An Umbrella Term for Disorders with Impaired Neurofluid Dynamics

Magnetic Resonance in Medical Sciences, Год журнала: 2022, Номер 23(1), С. 1 - 13

Опубликована: Ноя. 24, 2022

Interest in interstitial fluid dynamics has increased since the proposal of glymphatic system hypothesis. Abnormal have been pointed out to be an important factor various pathological statuses. In this article, we propose concept central nervous fluidopathy as a disease or condition which abnormal is one factors for development condition. We discuss aspects diseases, including Alzheimer's disease, Parkinson's normal pressure hydrocephalus, and cerebral small vessel disease. also method called "diffusion tensor image analysis along perivascular space" using MR diffusion images, used evaluate degree activity system.

Язык: Английский

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Glymphatic system dysfunction in restless legs syndrome: evidenced by diffusion tensor imaging along the perivascular space

SLEEP, Год журнала: 2023, Номер 46(11)

Опубликована: Сен. 11, 2023

There is growing evidence pointing at glymphatic system dysfunction in diseases with circadian disruption, such as sleep disorders. Lower diffusivity the direction of perivascular space has been shown several neurological and sleep-related disorders; however, its role restless legs syndrome (RLS) unclear. We hypothesized that similarly, RLS decreased. Here, we aimed to evaluate functionality patients RLS, compare it healthy controls, analyze correlation between function clinical characteristics.

Язык: Английский

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Glymphatic system impairment in nonathlete older male adults who played contact sports in their youth associated with cognitive decline: A diffusion tensor image analysis along the perivascular space study

Frontiers in Neurology, Год журнала: 2023, Номер 14

Опубликована: Фев. 15, 2023

Exposure to contact sports in youth causes brain health problems later life. For instance, the repetitive head impacts might contribute glymphatic clearance impairment and cognitive decline. This study aimed assess effect of participation on function old age relationship between status using analysis along perivascular space (ALPS) index.A total 52 Japanese older male subjects were included study, including 12 who played heavy-contact (mean age, 71.2 years), 15 semicontact 73.1 25 noncontact 71.3 years) their youth. All diffusion-weighted images (DWIs) acquired a 3T MRI scanner. The ALPS indices calculated validated semiautomated pipeline. from left right hemispheres compared groups general linear model, years education. Furthermore, partial Spearman's rank correlation tests performed scores (Mini-Mental State Examination version Montreal Cognitive Assessment [MoCA-J]) after adjusting for education HbA1c.The index was significantly lower than that group. Although no significant differences observed among groups, trend toward found individuals with Both sides' positively correlated MoCA-J scores.The findings indicated potential adverse experience system associated

Язык: Английский

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