Cancer Cell International,
Год журнала:
2021,
Номер
21(1)
Опубликована: Апрель 13, 2021
Abstract
Metformin
known
as
the
first-line
orally
prescribed
drug
for
lowering
blood
glucose
in
type
II
diabetes
(T2DM)
has
recently
found
various
therapeutic
applications
including
cancer.
been
studied
its
influences
prevention
and
treatment
of
cancer
through
multiple
mechanisms
such
microRNA
(miR)
regulation.
Alteration
expression
miRs
by
metformin
may
play
an
important
role
cancers.
MiRs
are
single-stranded
RNAs
that
involved
gene
By
binding
to
3′UTR
target
mRNAs,
influence
protein
levels.
Irregularities
control
oncogenes
tumor
suppressor
genes
associated
with
onset
progression
possess
effect
on
modifying
miR
downstream
pathways.
Here,
we
summarize
different
types
regulating
molecules.
Medicine,
Год журнала:
2020,
Номер
99(22), С. e20204 - e20204
Опубликована: Май 28, 2020
Prostate
cancer
is
the
second
leading
cause
of
cancer-related
deaths
among
male
population
worldwide,
its
incidence
and
lethality
steadily
increase.
Nuclear
enriched
abundant
transcript
1
(NEAT1)
a
long
non-coding
RNA
(ncRNA),
located
on
chromatin
11.
It
has
been
found
to
function
as
an
oncogene
in
different
kinds
cancer.
However,
until
now,
clinical
significance
NEAT1
not
investigated
prostate
cancer.Paired
tissue
specimens
matched
normal
tissues
were
obtained
from
130
patients
with
between
2014
2019
at
The
Fourth
Affiliated
Hospital
Zhejiang
University,
School
Medicine.
Group
means
compared
using
Student
t
test.
Chi-Squared
test
was
used
for
analyzing
correlation
expression
clinicopathologic
features
patients.
Survival
data
analyzed
Kaplan-Meier
estimate
log-rank
P
calculated.
Cox
regression
model
univariate
multivariate
analysis
factors
related
overall
survival.The
increased
significantly
tissues,
adjacent
(P
<
.001).
associated
TNM
stage
=
.005),
lymph
nodes
metastasis
distant
metastasis(P
.003),
Gleason
score
Overall
survival
rate
lower
high
level
than
those
low
NEAT1a
.048).
In
analysis,
results
showed
that
independent
prognostic
factor
patient
(HR:
2.111,
CI:
1.735-10.295,
.039).In
present
study,
identified
important
lncRNA
may
predict
prognosis
Bioscience Reports,
Год журнала:
2021,
Номер
41(7)
Опубликована: Апрель 26, 2021
Abstract
The
gastric
cancer
(GC)
patients
commonly
have
a
poor
prognosis
due
to
its
invasiveness
and
distant
metastasis.
Growing
evidence
proved
that
aberrant
long
non-coding
RNAs
(lncRNAs)
expression
contributes
tumor
development
progression.
LncRNA
SNHG15
has
been
reported
be
involved
in
many
different
kinds
of
cancer,
while
role
GC
remains
unclear.
In
the
present
study,
we
found
was
up-regulated
tissues
cell
lines.
Silencing
suppressed
proliferation
migration,
invasion
promoted
apoptosis
AGS
cells.
More
importantly,
microRNA-506-5p
(miR-506-5p)
predicted
as
direct
target
by
binding
3′-UTR
further
verified
using
luciferase
reporter
assay.
Meanwhile,
results
rescue
experiments
revealed
knockdown
miR-506-5p
reversed
functional
effects
silenced
proliferation,
apoptosis.
conclusion,
our
findings
executed
oncogenic
properties
progression
through
targeting
miR-506-5p,
which
might
provide
novel
for
treatment.
Cancer Cell International,
Год журнала:
2021,
Номер
21(1)
Опубликована: Апрель 13, 2021
Abstract
Metformin
known
as
the
first-line
orally
prescribed
drug
for
lowering
blood
glucose
in
type
II
diabetes
(T2DM)
has
recently
found
various
therapeutic
applications
including
cancer.
been
studied
its
influences
prevention
and
treatment
of
cancer
through
multiple
mechanisms
such
microRNA
(miR)
regulation.
Alteration
expression
miRs
by
metformin
may
play
an
important
role
cancers.
MiRs
are
single-stranded
RNAs
that
involved
gene
By
binding
to
3′UTR
target
mRNAs,
influence
protein
levels.
Irregularities
control
oncogenes
tumor
suppressor
genes
associated
with
onset
progression
possess
effect
on
modifying
miR
downstream
pathways.
Here,
we
summarize
different
types
regulating
molecules.
