AN UMBRELLA REVIEW ON TREATMENTS AND THERAPEUTIC OPTIONS FOR COVID-19 DOI Creative Commons
SeyedAhmad SeyedAlinaghi, Amir Masoud Afsahi, Ayoob Molla

и другие.

Russian Journal of Infection and Immunity, Год журнала: 2023, Номер 13(5), С. 885 - 898

Опубликована: Окт. 20, 2023

Introduction. As the COVID-19 pandemic continues to pose a significant challenge global health, effective therapeutic options for preventing and treating disease have become increasingly important. We aimed provide an update on current treatments patients.Materials methods. The purpose of this umbrella review is explore patients. Keywords their combinations were searched across online databases in Embase, PubMed/MEDLINE, Web Science, Scopus spanning from July 1, 2020, through March 3, 2023. Publications selected data extraction two steps based study inclusion/exclusion criteria. adheres PRISMA checklist as well NIH bias risk quality assessment tool.Results. In review, 28 relevant articles final qualitative synthesis. majority included studies had reported efficacy Lopinavir/Ritonavir (n = 4), Ivermectin 3), Baricitinib 2), Tocilizumab Remdesivir ACEI/ARB Vitamin D Molnupiravir Traditional Chinese medicine (TCM) Convalescent plasma transfusion (CPT) 2) hydroxychloroquine COVID-19. It appeared that Baricitinib, Remdesivir, ACEI/ARB, TCM, CPT may beneficial effects reducing mortality, hospitalization duration, severity Other interventions, such Lopinavir/Ritonavir, Ivermectin, D, Hydroxychloroquine did not show clear benefits or inconclusive results.Conclusion. This provides comprehensive overview evidence effectiveness safety various pharmacological non-pharmacological interventions These results updated landscape treatments, highlighting potential avenues further research clinical practice. crucial continue monitoring emerging conducting rigorous guide development optimization strategies against

Язык: Английский

N-acetylcysteine reduces severity and mortality in COVID-19 patients: A systematic review and meta-analysis DOI Creative Commons
Mohammad Shah Alam, Mohammad Nazmol Hasan,

Zannatul Maowa

и другие.

Journal of Advanced Veterinary and Animal Research, Год журнала: 2023, Номер 10(2), С. 157 - 157

Опубликована: Янв. 1, 2023

Recent clinical studies suggest that oxidative stress is one of the key players in pathogenesis coronavirus disease 2019 (COVID-19), and N-acetylcysteine (NAC), a potent antioxidant, has been shown to improve outcomes COVID-19 patients. We conducted systematic review meta-analysis literature published on therapeutic intervention NAC infection.We searched PubMed, Google Scholar, Science Direct. identified screened eight with 20,503 participants, including 2,852 NAC-treated group 17,651 placebo group, which reported effect infection. A was performed using forest plots under fixed estimates based standardized mean difference (SMD) risk ratio (RR).Pooled analysis showed associated lower mortality patients compared [RR, 0.65; (95% CI: 0.56 0.75); p < 0.0001]. Similarly, C-reactive protein (CRP) [SMD, -0.32; -56 -0.09); = 0.0070] D-dimer -0.35, -0.59 -0.10; 0.0062] levels were significantly decreased, oxygenation marker, PaO2/FiO2 ratio, increased 0.76; 0.48 1.03); 0.0001].Although number included minimal, this suggests may have positive outcomes, specifically, significant decrease CRP increase oxygen saturation, decreased mortality. also presented comprehensive role mechanisms COVID-19.

Язык: Английский

Процитировано

13
Exploring autophagy in treating SARS-CoV-2 spike protein-related pathology DOI Creative Commons
Matthew Halma, Paul E. Marik,

Yusuf M. Saleeby

и другие.

Endocrine and Metabolic Science, Год журнала: 2024, Номер 14, С. 100163 - 100163

Опубликована: Янв. 30, 2024

Fasting, a practice with historical roots in various cultures, has recently garnered significant interest the field of medicine. In this article, we delve into mechanisms underlying fasting-induced autophagy and its therapeutic applications for spike protein associated pathology. We explore potential fasting on protein-related pathology role interventions to upregulate autophagy, including compounds like spermidine, resveratrol, rapamycin, metformin. conclusion, fasting, coupled an understanding nuances, holds promise as intervention SARS-CoV-2 related diseases; broad implications human health. This review presents possibility using treat diseases, details deploy modality.

Язык: Английский

Процитировано

3
The Role of Nutraceuticals in the Prevention and/or Treatment of COVID-19: An Umbrella Review DOI Open Access

Randa Karzon,

Andrew Jackson,

Iva Lloyd

и другие.

CAND Journal, Год журнала: 2023, Номер 30(4), С. 66 - 80

Опубликована: Дек. 28, 2023

Background: To identify the results of published review literature regarding nutraceuticals, including probiotics, melatonin, poly-unsaturated fatty acids (PUFAs), quercetin, N-acetyl cysteine (NAC), and propolis as they relate to prevention and/ or treatment COVID-19 (CV) and/or long COVID (long CV) outline key areas consider for clinical application further research. Methods: This paper is part a six-part umbrella which progresses from living review. incorporates systematic reviews narrative nutraceuticals. A live search occurred monthly in PubMed Google Scholar May 2022 2023. Assessing Methodological Quality Systematic Reviews Version 2 (AMSTAR-2) scoring assessed quality, while Scale Assessment Narrative Review Articles (SANRA) guidelines evaluated reviews. Only those studies that were relevant nutraceuticals outlined above addressed CV extracted each Results: Fifteen 16 included this Studies indicate may be beneficial improving rate recovery various symptoms, conversion parameters such duration hospital stay risk intensive care unit (ICU) admission, an improvement laboratory tests. Conclusion/Summary: The broad antioxidant, anti-inflammatory, antiviral, immune modulatory characteristics make reasonable choices Of discussed above, NAC, quercetin greatest potential benefit CV.

Язык: Английский

Процитировано

8
Redox regulation of defense against bacterial and viral pathogens DOI Creative Commons
Pietro Ghezzi, Anna Rubartelli

Current Opinion in Chemical Biology, Год журнала: 2023, Номер 76, С. 102339 - 102339

Опубликована: Июнь 8, 2023

There is considerable interest in the role of oxygen-derived oxidants (often termed generically reactive oxygen species), and potential effect exogenous antioxidants, pathogenesis infectious disease. Most published research focuses on inflammatory response concept that are pro-inflammatory antioxidants anti-inflammatory. The present review discusses evidence both thiol important various processes innate adaptive immunity, focusing function immune system defense against pathogens, rather than its pathogenic autoimmune

Язык: Английский

Процитировано

3
Impact of N-Acetylcysteine in the mortality of patients hospitalized with COVID-19: a retrospective cohort study DOI

M.A. Galindo-Andúgar,

Ángel Arias, José Alfonso García Guerra

и другие.

Revista Clínica Española (English Edition), Год журнала: 2023, Номер 223(8), С. 479 - 485

Опубликована: Июль 21, 2023

Язык: Английский

Процитировано

2
Efecto de la N-acetilcisteína en la mortalidad de pacientes ingresados por COVID-19: estudio de cohorte retrospectivo DOI

M.A. Galindo-Andúgar,

Ángel Arias, José Alfonso García Guerra

и другие.

Revista Clínica Española, Год журнала: 2023, Номер 223(8), С. 479 - 485

Опубликована: Авг. 7, 2023

Процитировано

2
Covid-19 Clinical Outcomes and N-Acetylcysteine (Covinac Study): A Grade Compliant Meta-Analysis of Randomized Controlled Trials, Molecular Docking, and Dynamics Simulations with Mpro of Sars-Cov-2 DOI
Seshadri Reddy Varikasuvu, Subodh Kumar, Manne Munikumar

и другие.

Опубликована: Янв. 1, 2024

Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL DOI

Язык: Английский

Процитировано

0
The value of N-acetylcysteine bronchoalveolar lavage in patients with severe traumatic brain injury combined with ventilator-associated pneumonia DOI
Yujuan Li,

Jing Lü

Materials Express, Год журнала: 2024, Номер 14(7), С. 1011 - 1017

Опубликована: Апрель 18, 2024

In order to improve the treatment of patients with ventilator-associated pneumonia (VAP) in severe traumatic brain injury (TBI) and effectively suppress inflammatory response enhance blood oxygen indicators, we conducted an innovative bronchoalveolar lavage (BAL) using N-acetylcysteine (NAC). To conduct this study, divided VAP TBI into a control (CTRL) group BAL group. The received saline, while NAC addition standard care. We compared clinical treatment, degree inflammation, index, safety both groups pre- post-BAL. results showed that was more effective reducing duration antibiotic use, imaging uptake, fever reduction, mechanical ventilation, ICU stay, as well CPIS APACHE II scores. Moreover, demonstrated greater improvement indicated by increased values PaO 2 , SaO OI, substantial decrease PaCO . Furthermore, suppressed level body significantly reduced TNF- α CPR, PCT MIP-1 levels. Adjuvant improved outcomes mortality VAP, maintaining high during operation. Therefore, holds significant potential salvage combined VAP.

Язык: Английский

Процитировано

0
Assessing the neutralizing antibody and duration of RNA positivity from COVID-19 infected patients with immunocompromised diseases and pneumonia DOI Creative Commons
Shuo Liu, Xuelian Wu,

Ziteng Liang

и другие.

Molecular Biomedicine, Год журнала: 2024, Номер 5(1)

Опубликована: Июль 28, 2024

Язык: Английский

Процитировано

0
Effectiveness of N-acetylcysteine in treating patients with coronavirus disease 2019 may be in doubt but in uncertainty DOI Creative Commons

Wen-Ling Lee,

Szu‐Ting Yang,

Peng‐Hui Wang

и другие.

Journal of the Chinese Medical Association, Год журнала: 2023, Номер unknown

Опубликована: Май 25, 2023

aDepartment of Medicine, Cheng-Hsin General Hospital, Taipei, Taiwan, ROC bInstitute Clinical National Yang Ming Chiao Tung University, cDepartment Nursing, Oriental Institute Technology, New Taipei City, dDepartment Obstetrics and Gynecology, Veterans eFemale Cancer Foundation, Received date: May 19, 2023 Accepted 20, 2023. Conflicts interest: Dr. Peng-Hui Wang, an editorial board member at Journal the Chinese Medical Association, had no role in peer review process or decision to publish this article. The other authors declare that they have conflicts interest related subject matter materials discussed *Address Correspondence. Department 201, Section 2, Shi-Pai Road, 112, ROC. Tel: 886 2 28757566; Fax: 55702788; E-mail addresses: [email protected]; This is open access article under CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)

Язык: Английский

Процитировано

1