Journal of Medicinal and Chemical Sciences,
Год журнала:
2022,
Номер
6(6)
Опубликована: Ноя. 19, 2022
Nowadays,
nanoparticles
(NPs)
are
used
for
agricultural
purposes,
such
as
developing
germination
of
the
seeds
and
enhancing
nutrients
in
soil.
They
also
applied
synthesis
nanopesticides
nanofertilizers.
The
current
study
was
carried
out
to
examine
effect
using
zirconium
oxide,
yttrium
other
solutions
(Gibberellin,
Indol
acetic
acid
(IAA),
Naphthol
(NAA)
maize
seeds.
Before
germination,
weighted
a
dry
seed,
then
they
were
soaked
solution
70%
alcohol,
it
sterile
by
water.
After
that,
immersed
one
14
2
hours.
Next,
wet
seeds,
transferred
petri
dishes
120
hours
at
25°C.
five
days,
plants
taken
from
Petri
dishes,
studied,
evaluated
calculating
percentage,
rate,
measuring
number,
length
roots,
shots.
It
is
noticed
that
best
Zirconium
100
+
IAA
Yttrium
µg
both
which
had
significant
difference
(p<0.05)
indicate
highest
percentage
100%
rate
0.6.
Different
concentrations
combinations
prepared
successfully
treatment
results
compared
found
test
considered
(p<0.05).
However,
authors
recommend
examination
temperature
humidity
on
future
work.
Journal of Medicinal and Chemical Sciences,
Год журнала:
2022,
Номер
5(5)
Опубликована: Май 5, 2022
In
recent
times,
many
researchers
in
pharmaceutical
chemistry
have
been
preoccupied
with
the
quest
for
new
potent
anti-infective
agents
to
combat
antimicrobial
resistance.
A
novel
series
of
naphthalene-based
derivatives
were
synthesized
as
part
these
studies.
Different
spectral
techniques,
such
UV–Vis,
FTIR,
13C-NMR,
and
1H-NMR
used
affirm
compounds'
chemical
structures,
while
an
ADME
study
was
conducted
investigate
their
pharmacokinetics
drug-like
properties.
The
potential
candidates
versus
pathogenic
microbes
evaluated
using
a
broth
microdilution
assay.
These
involved
six
aerobic
gram-negative
bacteria,
four
anaerobic
two
fungi.
addition,
safety
assessed
normal
bacterial
flora.
From
obtained
results,
authors
reported
following
principal
outcomes:
Compound
SF5
revealed
significant
bactericidal
impact
indicating
high
non-pathological
strain.
Most
demonstrated
outstanding
fungicidal
candidates,
but
compound
SF1
most
one.
According
analysis,
almost
all
good
theoretical
drug-likeness
characteristics
making
them
suitable
oral-derived
agents.
Journal of Medicinal and Chemical Sciences,
Год журнала:
2023,
Номер
6(9)
Опубликована: Май 8, 2023
Nonsteroidal
anti-inflammatories
(NSAIDs),
are
very
effective
agents
in
relieving
mild
to
moderate
pain
and
inflammation
by
inhibiting
two
isoforms
of
prostaglandin
G-H
synthetase
(I
II).
In
the
present
work,
anthranilic
acid
derivatives'
electronic
physicochemical
properties
reported
utilizing
quantum
chemical
calculations
that
use
density
functional
theory
(DFT),
which
forecast
properties.
To
clarify
type
composition,
drug-likeness,
cyclooxygenase
inhibitor,
ADME
molecular
docking
were
used.
The
molecule
was
highly
electrophilic
relatively
stable
from
a
computation
perspective.
contour
maps
HOMO-LUMO
electrostatic
potential
examined
display
charge
distributions
might
be
related
biological
activity.
