Gut microbiota in health and disease: advances and future prospects
MedComm,
Год журнала:
2024,
Номер
5(12)
Опубликована: Ноя. 20, 2024
Abstract
The
gut
microbiota
plays
a
critical
role
in
maintaining
human
health,
influencing
wide
range
of
physiological
processes,
including
immune
regulation,
metabolism,
and
neurological
function.
Recent
studies
have
shown
that
imbalances
composition
can
contribute
to
the
onset
progression
various
diseases,
such
as
metabolic
disorders
(e.g.,
obesity
diabetes)
neurodegenerative
conditions
Alzheimer's
Parkinson's).
These
are
often
accompanied
by
chronic
inflammation
dysregulated
responses,
which
closely
linked
specific
forms
cell
death,
pyroptosis
ferroptosis.
Pathogenic
bacteria
trigger
these
death
pathways
through
toxin
release,
while
probiotics
been
found
mitigate
effects
modulating
responses.
Despite
insights,
precise
mechanisms
influences
diseases
remain
insufficiently
understood.
This
review
consolidates
recent
findings
on
impact
immune‐mediated
inflammation‐associated
conditions.
It
also
identifies
gaps
current
research
explores
potential
advanced
technologies,
organ‐on‐chip
models
microbiome–gut–organ
axis,
for
deepening
our
understanding.
Emerging
tools,
single‐bacterium
omics
spatial
metabolomics,
discussed
their
promise
elucidating
microbiota's
disease
development.
Язык: Английский
From Inflammasomes to Pyroptosis: Molecular Mechanisms in Chronic Intestinal Diseases — Opportunity or Challenge?
Journal of Inflammation Research,
Год журнала:
2025,
Номер
Volume 18, С. 3349 - 3360
Опубликована: Март 1, 2025
Pyroptosis
is
a
unique
form
of
programmed
cell
death
characterized
by
intense
inflammation.
It
involves
the
activation
Gasdermin
proteins,
which
membrane
pores,
leading
to
rapid
rupture
and
release
inflammatory
molecules.
Unlike
other
types
death,
pyroptosis
has
distinct
mechanisms
plays
complex
role
in
chronic
intestinal
diseases,
including
bowel
disease,
fibrosis,
infectious
enteritis,
colorectal
cancer.
This
review
comprehensively
examines
how
influences
disease
development
progression
while
exploring
therapeutic
potential
targeting
pyroptosis-related
pathways.
Moreover,
interplay
between
gut
microbiota
summarized,
highlighting
its
critical
pathogenesis
disorders.
A
deeper
understanding
these
diseases
may
provide
valuable
insights
for
future
research
contribute
innovative
strategies
gastroenterology.
Язык: Английский