Frontiers in Cellular Neuroscience,
Год журнала:
2023,
Номер
17
Опубликована: Дек. 20, 2023
Social
and
emotional
experiences
differently
shape
individual’s
neurodevelopment
inducing
substantial
changes
in
neurobiological
substrates
behavior,
particularly
when
they
occur
early
life.
In
this
scenario,
the
present
study
was
aimed
at
(i)
investigating
impact
of
social
environments
on
reactivity
adolescent
male
female
rats
(ii)
uncovering
underlying
molecular
features,
focusing
cortical
endocannabinoid
(eCB)
glucocorticoid
systems.
To
aim,
we
applied
a
protocol
environmental
manipulation
based
postnatal
socially
enriched
or
impoverished
conditions.
enrichment
realized
through
communal
nesting
(CN).
Conversely,
an
isolation
(ESI)
(post-natal
days
14–21)
to
mimic
adverse
environment.
The
two
forms
resulted
specific
behavioral
outcomes
both
rat
offspring.
Despite
combination
CN
ESI
did
not
affect
sexes,
results
reveal
that
preventive
exposure
altered
mRNA
protein
expression
main
components
eCB
systems
rats.
particular,
females
exposed
showed
increased
corticosterone
levels,
unaltered
genomic
receptor,
reduced
cannabinoid
receptor
type-1
fatty
acid
amide
hydrolase
suggesting
condition
evokes
different
reorganization
these
males
females.
Genes,
Год журнала:
2023,
Номер
14(7), С. 1506 - 1506
Опубликована: Июль 24, 2023
Nutrition
and
metabolism
modify
epigenetic
signatures
like
histone
acetylation
DNA
methylation.
Histone
methylation
in
the
central
nervous
system
(CNS)
can
be
altered
by
bioactive
nutrients
gut
microbiome
via
gut-brain
axis,
which
turn
modulate
neuronal
activity
behavior.
Notably,
microbiome,
with
more
than
1000
bacterial
species,
collectively
contains
almost
three
million
functional
genes
whose
products
interact
millions
of
human
marks
30,000
a
dynamic
manner.
However,
genetic
makeup
shapes
composition,
food/nutrient
metabolism,
landscape,
as
well.
Here,
we
first
discuss
effect
changes
microbial
structure
composition
shaping
specific
alterations
brain
their
role
onset
progression
major
mental
disorders.
Afterward,
potential
interactions
among
maternal
diet/environmental
factors,
nutrition,
gastrointestinal
roles
accelerating
or
delaying
severe
illnesses
will
discussed.
We
also
provide
an
overview
association
between
oxidative
stress,
inflammation
through
mechanisms.
Finally,
present
some
underlying
mechanisms
involved
mediating
influence
probiotics
on
health
modifications.
Biomedicines,
Год журнала:
2024,
Номер
12(9), С. 1978 - 1978
Опубликована: Сен. 2, 2024
Stress
profoundly
affects
physical
and
mental
health,
particularly
when
experienced
early
in
life.
Early-life
stress
(ELS)
encompasses
adverse
childhood
experiences
such
as
abuse,
neglect,
violence,
or
chronic
poverty.
These
stressors
can
induce
long-lasting
changes
brain
structure
function,
impacting
areas
involved
emotion
regulation,
cognition,
response.
Consequently,
individuals
exposed
to
high
levels
of
ELS
are
at
an
increased
risk
for
health
disorders
like
depression,
anxiety,
post-traumatic
disorders,
well
issues,
including
metabolic
cardiovascular
disease,
cancer.
This
review
explores
the
biological
psychological
consequences
early-life
adversity
paradigms
rodents,
maternal
separation
deprivation
limited
bedding
nesting.
The
study
these
experimental
models
have
revealed
that
organism’s
response
is
complex,
involving
genetic
epigenetic
mechanisms,
associated
with
dysregulation
physiological
systems
nervous,
neuroendocrine,
immune
systems,
a
sex-dependent
fashion.
Understanding
impact
crucial
developing
effective
interventions
preventive
strategies
humans
stressful
traumatic
childhood.
Cells,
Год журнала:
2024,
Номер
13(22), С. 1875 - 1875
Опубликована: Ноя. 13, 2024
The
endocannabinoid
signalling
system
(ECS)
plays
a
critical
role
from
the
very
beginning
of
embryogenesis.
Accordingly,
ECS
is
engaged
early
on
in
nervous
development,
starting
neurulation,
supported
by
identification
components—both
receptors
and
enzymes
controlling
metabolism—at
these
stages.
In
particular,
regarding
brain,
involved
tightly
regulated
sequence
events
that
comprise
brain
neurogenesis
to
neuronal
migration,
morphological
guidance
for
connectivity,
synaptic
circuitry
refinement.
importance
this
broad
across
various
development
processes
further
underscored
growing
understanding
consequences
cannabis
exposure
at
different
developmental
Despite
considerable
knowledge
we
have
significant
gaps
our
remain,
particularly
long-term
impact
underlying
mechanisms
This
review
provides
an
overview
current
state
throughout
embryogenesis
adulthood,
discusses
exposure,
especially
during
adolescence—a
period
maturation
refinement
coinciding
with
increased
risk
use.
Genes,
Год журнала:
2023,
Номер
14(10), С. 1946 - 1946
Опубликована: Окт. 16, 2023
Gene
variation
linked
to
physiological
functions
is
recognised
affect
elite
athletic
performance
by
modulating
training
and
competition-enabling
behaviour.
The
fatty
acid
amide
hydrolase
(FAAH)
has
been
investigated
as
a
good
candidate
for
drug
targeting,
recently,
its
single-nucleotide
polymorphism
(SNP)
rs324420
was
reported
be
associated
with
performance.
Given
the
implications,
biological
pathways
of
this
genetic
performance,
considering
sport
type,
psychological
traits
sports
injuries,
need
dissected.
Thus,
narrative
review
literature
concerning
mechanisms
SNP
undertaken.
In
addition
role
in
FAAH
also
involved
important
underlying
human
psychopathologies,
including
substance
abuse
neural
dysfunctions.
However,
cumulative
evidence
C385A
variant
inconsistent.
Therefore,
validation
studies
homogeneous
modalities
are
required
better
define
impact
on
stress
coping,
pain
regulation
inflammation
control.
Neurourology and Urodynamics,
Год журнала:
2024,
Номер
43(5), С. 1104 - 1108
Опубликована: Янв. 30, 2024
Abstract
Introduction
One‐time
life
events
such
as
neurological
injury
can
result
in
lifelong
lower
urinary
tract
symptoms
(LUTS).
However,
it
is
unclear
whether
an
apparently
transient
event
also
trigger
long‐term
LUTS.
This
review
examines
the
possibility
of
association
and
hypothesizes
pathogenesis.
Methods
A
pubmed
search
was
conducted
using
MeSH
words
“life
change
events,”
“child
abuse,”
or
“stress
disorders,
Posttraumatic”,
Additional
manuscripts
were
identified
by
a
hand
citation
search.
Results
Long‐term
LUTS
noted
following
temporally
remote
childhood
sexual
abuse,
adverse
experiences,
stressful
experiences
adults.
There
evidence
for
abuse
with
both
storage
well
voiding
limited
that
number
might
increase
risk
severity
between
post‐traumatic
stress
disorder
adults
The
finding
mental
health
disorders
patients
could
explain
some
but
not
all
observed
suggesting
other
factors
be
important.
Conclusions
lifetime
subsequent
reporting
timing
these
important
determining
propensity
clinical
manifestation.
need
to
explore
this
association,
establish
causality,
determine
underlying
etiopathogenesis.
