Identification of bioactive compounds in hydro-alcoholic extract of cinnamon by GC-MS ‎analysis and evaluation of its in-vitro anti-gastric cancer potential DOI Open Access
Mina Owrang,

Alam Gholami,

Alireza Rafiei

и другие.

Bioactive Compounds in Health and Disease - Online ISSN 2574-0334 Print ISSN 2769-2426, Год журнала: 2024, Номер 7(5), С. 265 - 273

Опубликована: Май 27, 2024

Background: Despite the availability of various treatment methods for gastric cancer, herbal medicine remains a promising candidate. This study aimed to identify bioactive compounds in hydroalcoholic extract (CHE) cinnamon ‎‎(Cinnamomum zeylanicum) using gas chromatography-mass spectrometry (GC-MS) analysis. Objectives: ‎To phytochemical constituents from zeylanicum). Methods: The CHE ‎was tested cytotoxicity against normal human epithelium cell line (GES‐1) and ‎gastric adenocarcinoma ‎‎(AGS) as model cancer. Results: analysis revealed six main ‎phytochemical CHE, with ‎cinnamaldehyde being predominant compound. showed potent AGS at concentrations ranging 100-600 μg/mL, significantly reducing ‎the viability these cancerous cells 20.88%‎‏ ‏compared control group (p<0.05). ‎In contrast, did not affect GES‐1 ‎cells. Conclusion: findings ‎obtained suggest avenue finding new anticancer ‎chemotherapeutic agents cancer.‎ Keywords: anticancer; compounds; cinnamon;

Язык: Английский

The effect of phenolic compounds contained in flour from green buckwheat, flaxseed, grape and dogwood seeds on the fermentation activity of yeast S. cerevisiae DOI Open Access
Svetlana A. Grinvald, Nadezhda V. Barakova,

Elena I. Kiprushkina

и другие.

Functional Foods in Health and Disease, Год журнала: 2024, Номер 14(3), С. 208 - 218

Опубликована: Март 29, 2024

Background: Bakery products are one of the most widely consumed in world, but they have very low nutritional value and a short shelf life. Unconventional flour can be used to address these issues. They contain vitamins, minerals, polyphenols that significantly increase final product. It is known phenolic compounds beneficial effect on human body, preventing various diseases, inactivating free radicals, also suppressing growth pathogenic microorganisms develop bakery products. Despite advantages, unconventional types specific biochemical composition negatively affect course technological process. One important stages production fermentation. Earlier studies shown adsorbed by yeast, high concentrations reduce viability yeast cells. Objective: To study influence flavonoid contained from green buckwheat, flax, grape, dogwood seeds fermentative activity S. cerevisiae yeast. achieve this goal, it was necessary determine total amount substances grape seeds, flax flour, individual The common polyphenolic all three were selected for – rutin, gallic acid, tannin. Methods: fermentation assessed measuring carbon dioxide release during fermentation, with samples prepared using varying seeds. Ethanol extraction raw materials conducted 60% ethyl alcohol, followed spectrophotometric determination content. Rutin, tannin, acid defined titration methods. Results: found contains highest compared other namely: 1352 milligrams acid/100 grams 227 rutin/100 respectively. lowest buckwheat 350 109 addition tested positively affects bread increasing 1.5-2 times control sample. CO2 released when Studies showed tannin flour. Individual positive process release. adding 120 mg rutin per 1 gram which 2 higher than values relative noted introduction shortened lag phase increased logarithmic phase. intense first hours. Conclusion: A promising direction use baking. Since does not negative source extend life In addition, additional consumption diet has health. Keywords: seed flaxseed activity,

Язык: Английский

Процитировано

3

Identification of bioactive compounds in hydro-alcoholic extract of cinnamon by GC-MS ‎analysis and evaluation of its in-vitro anti-gastric cancer potential DOI Open Access
Mina Owrang,

Alam Gholami,

Alireza Rafiei

и другие.

Bioactive Compounds in Health and Disease - Online ISSN 2574-0334 Print ISSN 2769-2426, Год журнала: 2024, Номер 7(5), С. 265 - 273

Опубликована: Май 27, 2024

Background: Despite the availability of various treatment methods for gastric cancer, herbal medicine remains a promising candidate. This study aimed to identify bioactive compounds in hydroalcoholic extract (CHE) cinnamon ‎‎(Cinnamomum zeylanicum) using gas chromatography-mass spectrometry (GC-MS) analysis. Objectives: ‎To phytochemical constituents from zeylanicum). Methods: The CHE ‎was tested cytotoxicity against normal human epithelium cell line (GES‐1) and ‎gastric adenocarcinoma ‎‎(AGS) as model cancer. Results: analysis revealed six main ‎phytochemical CHE, with ‎cinnamaldehyde being predominant compound. showed potent AGS at concentrations ranging 100-600 μg/mL, significantly reducing ‎the viability these cancerous cells 20.88%‎‏ ‏compared control group (p<0.05). ‎In contrast, did not affect GES‐1 ‎cells. Conclusion: findings ‎obtained suggest avenue finding new anticancer ‎chemotherapeutic agents cancer.‎ Keywords: anticancer; compounds; cinnamon;

Язык: Английский

Процитировано

1