Anti-diabetic effect of a combination of black seed (Nigella sativa) and cumin (Cuminum cyminum), a two-step study from bench to bed

Functional Food Science - Online ISSN 2767-3146, Год журнала: 2024, Номер 4(2)

Опубликована: Фев. 19, 2024

Background: Type 2 Diabetes mellitus (T2DM) is a prevalent chronic condition causing one-fifth million deaths globally. Standard treatments for diabetes are not sufficiently effective, highlighting the need to find adjunctive improve glycemic control. Nigella sativa (NS) and Cuminum cyminum (CC) two herbal medicines known their antioxidant, anti-inflammatory, antidiabetic properties. Objective: This study aims assess impact of supplementation with combination NS CC on regulation among individuals T2DM. The research was conducted in phases, pre-clinical clinical. Methods: In in-vivo phase, thirty-two male mice were allocated into four groups, each comprising eight mice. These groups categorized as follows: control, diabetic-type 2, diabetic-intervention-NS, diabetic-intervention-NS+CC. Following induction using Streptozotocin, NS-CC received 400 mg/kg/d or 360 oil plus 40 respectively 30 days. An insulin tolerance test (ITT), an intraperitoneal glucose (IPGTT), blood subsequently. clinical study, eighty patients who have been clinically diagnosed type randomly assigned distinct receive daily dosage 2000 mg soft gel sunflower 12 weeks. examination fasting (FBG) hemoglobin A1C (HbA1C) performed both before after completion intervention. Results: Preclinical findings exhibited notable decrease levels (decrease from 271.1±21.71 167.6±8.14 mg/dl) 275.4±25.57 136±13.07 mg/dl). Also, ITT IPGTT showed significantly more reduction compared non-treated diabetic group. Treating NS-CC, but alone decreased normal level no significant difference non-diabetic phase led greater mean sugar (FBS) (P=0.001) concentration HbA1C (P<0.001) placebo. Conclusions: may reduce resistance murine models Keywords: sativa, cyminum, mellitus, Glycemic Diabetic

Язык: Английский

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Assessment of the impact of micro fertilizers on winter wheat and winter barley crops under the Sevan basin conditions

Bioactive Compounds in Health and Disease - Online ISSN 2574-0334 Print ISSN 2769-2426, Год журнала: 2024, Номер 7(4), С. 199 - 210

Опубликована: Апрель 16, 2024

Background: Microelements are crucial for numerous physiological and biochemical processes in plant life. They constitute parts of various vitamins enzymes, stimulate respiration, accelerate oxidation regeneration reactions, positively impacting protein metabolism organisms. Objective: Considering the significant role microelements living organisms, our aim is to investigate effectiveness applying microfertilizers biohumus on growth, development, quality winter wheat barley. We conducted field experiments laboratory research analyze impact trace element content soil at experimental sites. This holds particular significance amidst ongoing global climate changes, emphasizing urgency relevance study․ Methods: Field experiments, both barley, were set up with three replications, same fertilization scheme. The size each plot was 30 m2, crop area 630 m2 consisting following types: 1. Control (non-fertilized); 2. biohummus t/ha; 3. Background+Mn (MnSO4 4H2O); 4. Background +Cu (CuSO4. 5H2O); 5. Background+B (Na2 B407.10 H2O); 6. + Mo (HH4)2MoO4; 7. +Zn (ZnSO45H2O): Microfertilizers used pre-sowing seed treatment. Results: three-year results studies revealed that amount harvest indicators these crops increased from application molybdenum, manganese, copper sowing autumn barley background biohumus. increase under influence elements 3.3-6.4 c/ha (6.9-13.3%), grain compared 2.6-5.4 c/ha. ha, or 6.5-13.4%. A certain nitrogen grains can be seen as an indicator a problem necessary According research, it found spikelets high versions received copper. Specifically, wheat, ranges 2.64-2.68% Mo, 2.53-2.57% Cu, grains, 2.16-2.24% 2.08-2.10% 2.02-2.07% Mn. Simultaneously studies, proved yield did not undergo changes Zn B, which explained by higher total mobile forms soil. Conclusion: In practice fertilizing such it's essential judiciously use specific micro fertilizers like molybdenum ammonium (NH4MoO4), manganese sulfate · 4H2O), (CuSO4 5H2O). These should applied alongside organic ensure receive comprehensive supply macroelements. approach only guarantees production high-quality but also plays pivotal managing within them, nutritional value overall health. Keywords: microelements, growth quantity

Язык: Английский

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Effects and medical application of plant-origin polyphenols: A narrative review

Bioactive Compounds in Health and Disease - Online ISSN 2574-0334 Print ISSN 2769-2426, Год журнала: 2024, Номер 7(8), С. 375 - 385

Опубликована: Авг. 31, 2024

The impact of oxidative stress in the pathogenesis various diseases is well known. Oxidative occurs when there an imbalance between production reactive oxygen species (ROS) and ability a biological system to detoxify these intermediates or repair resulting damage. Polyphenols, diverse group compounds with antioxidant properties, help reduce damage by ROS. They are abundant fruits, vegetables, tea, coffee, wine, other plant-based foods. mechanisms their activity related regulate cellular signaling pathways, metal chelation, mitochondrial protection, while modulating enzyme exhibiting anti-inflammatory effects. Polyphenols can also through ROS scavenging, direct neutralization, enhancing defenses within cells. It has been established that polyphenols derived from plant do not harm metabolism normal cells, but involved metabolic pathways diseased which high redox sensitivity. Incorporating polyphenol-rich foods into diet beneficial for maintaining overall health reducing risk stress-related diseases. Researchers exploring therapeutic potential as dietary supplements functional medical applications. This review discusses origin, structure, benefits, application medicine food industry. Keywords: biologically active compounds, polyphenols, stress, activity, food.

Язык: Английский

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Menthol confers neuroprotection through Nrf2/ARE pathway in diabetic encephalopathy

Bioactive Compounds in Health and Disease - Online ISSN 2574-0334 Print ISSN 2769-2426, Год журнала: 2023, Номер 6(6), С. 108 - 108

Опубликована: Июнь 15, 2023

Background: Chronic, long-standing hyperglycemia in diabetes results diabetic encephalopathy (DE). It is hallmarked by cognitive dysfunction accelerated hyperglycemia-induced oxidative stress. Objective: This study explored the neuroprotective potency of menthol experimental diabetes.Methodology: Streptozotocin at a dose 40 mg/kg body weight was injected into eighteen male Sprague- Dawley rats intraperitoneally to induce diabetes. The animals were kept without treatment for period 30 days development DE. deficit confirmed Morris water maze test. Menthol (50 weight) administered orally 60 days. behavioral test conducted after treatment. Results obtained compared fed with metformin (100 weight). Animals then sacrificed get blood and brain tissue various biochemical examinations.Results:Treatment improved performance rats. In addition, significantly decreased fasting glucose, HbA1c, renal toxicity markers, lipid peroxidation products. enhances levels plasma insulin antioxidant enzymes. also upregulated mRNA expression Bcl-2, Nrf2, Glo-1, γ-GCS while diminishing Bax, cytochrome c, caspase-3. Conclusion:Menthol promotes neuroprotection abating deficits, attenuating hyperglycemia, regulating stress, curtailing apoptosis through Nrf2/ARE signaling. Keywords: Diabetic encephalopathy, Menthol, apoptosis, pathway

Язык: Английский

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Synergistic effect of partially hydrolyzed guar gum on Clostridium butyricum in a synbiotic combination for enhanced butyrate production during in-vitro fermentation

Functional Foods in Health and Disease, Год журнала: 2024, Номер 14(7), С. 455 - 469

Опубликована: Июль 8, 2024

Background: Clostridium butyricum is a butyrate-producing beneficial bacterium and generally recognized as significant indicator of appropriate gut microbial metabolism in human health. Objective: The synergistic effects commercially available prebiotic partially hydrolyzed guar gum (PHGG) dietary fiber carbon source on bacterial strain were evaluated during in-vitro fermentation with basal medium. Additionally, their activities compared to those other fibers. Methods: examined functional substrates (PHGG, LMW-PHGG, indigestible dextrin, inulin) demonstrated selective pH variation medium, leading enhanced growth butyrate production strains fermentation. Results: Prebiotic PHGG supplementation had the highest fermentability among fibers, resulting greater (OD660: 1.93 ± 0.01) generation (4.52 2.09 mM) after cultivation A difference promoting (p < 0.05), reduction 0.05) dextrin inulin was observed. Mannose strongest butyrogenic effect improved butyricum, studied monosaccharides (galactose, glucose, starch). order synthesis mannose > galactose glucose starch. relatively lower molecular weight (LMW-PHGG) exhibited similar trend observed when cultivated using PHGG-supplemented artificial intestinal fluid containing MRS-agar Conclusion: These findings suggest that symbiotic combination probiotic could have major industrial applications therapeutic adjuvant for gastrointestinal Keywords: Partially gum, synbiotic, prebiotic, probiotic,

Язык: Английский

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Non-thermal techniques for microbiological safety, nutritional preservation, and enhanced efficiency in dairy processing

Functional Food Science - Online ISSN 2767-3146, Год журнала: 2024, Номер 4(5), С. 180 - 203

Опубликована: Май 9, 2024

The ongoing era of adopted lifestyle among humans involves shortcuts in every aspect, and a similar trend can be observed food processing preservation, especially dairy preparation. Thus, lots non-thermal processes including high-pressure (HPP), ultrasound (US) treatment, pulsed electric fields (PEF), ultraviolet (UV) light oscillating magnetic (OMF), etc. have been invented. By inactivating bacteria, these keep food's sensory nutritional quality while also preventing thermal degradation components near ambient temperatures. Non-thermal techniques effectively preserve nutraceuticals functional potential, simultaneously ensuring microbiological safety maintaining the integrity its bioactive components. During processing, several heat-labile milk products may lost In contrast, are gentler compared to treatments, making them preferred choices that avoid compromising value. It has technology increase efficiency microstructure through constituent interactions, alteration enzyme activity, development hypoallergenic products. However, order use technologies profitably, risk operation, equipment cost, technological compatibility, goal product must thoroughly assessed prior using processes. combined with other strategies like addition bio-preservatives or modified atmospheric packaging etc., enhance antimicrobial effects. Keywords: processes; Microbiological safety; Dairy processing; Bioactive components; compounds; Enzyme activity; Nutritional quality; Bio-preservatives.

Язык: Английский

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Economic implications of functional foods

Functional Food Science - Online ISSN 2767-3146, Год журнала: 2024, Номер 4(6), С. 216 - 227

Опубликована: Июнь 6, 2024

Functional food products (FFPs) and their constituents, known as bioactive compounds (FBCs), possess distinctive properties that may mitigate the risk of specific diseases, offering a potential alternative to conventional medicine. Fruits vegetables contain components such vitamins, minerals, flavonoids, anthocyanins, others, which play role in managing symptoms chronic diseases. This review explores impact functional on economy. The rising costs associated with Western medical treatments for exacerbated by side effects medication, stresses importance exploring non-medical alternatives. Furthermore, absence definitive definition U.S. Food Drug Administration (FDA) adds weakness sector United States. On other hand, Japan has initiated regulatory system Specified Health Uses (FOSHU), introduces foods market educates consumers health benefits. Subsequently, they have also introduced new called Foods Claims. Despite limitations insufficiency post-market research, clinical studies, epidemiological studies both systems, continues outperform industry. Establishing its own could not only enable FDA compete more effectively but lead significant improvements life expectancy By examining regulations countries, this sheds light how contribute improved public economic outcomes. Keywords: Products, Bioactive Compounds, Administration, Uses, Claims, Economy

Язык: Английский

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Strategic food reserves storage, safety and risk minimization: Problems and perspectives

Functional Foods in Health and Disease, Год журнала: 2024, Номер 14(8), С. 615 - 629

Опубликована: Авг. 30, 2024

Background: The hunger problem is a significant issue arising from global challenges in the 21st century. It consequence of inadequate food safety and poor strategic storage. This makes innovations improvements these areas particularly crucial, especially for developing countries regions affected by military conflicts natural disasters. Context purpose this study: We aimed to study carbonate limestone caves as potentially safe locations constructing storage facilities. Results: preliminary results Magellan Cave (Magill Cave) Areni region Republic Armenia indicate that cave has suitable conditions use potential site storage, cereal grains. Biological studies have proved absence mesophilic microbes rock minerals soil samples its inner space. Additionally, psychrophilic microbes, thermophilic algae, representatives Cyanobionta were found waters meet underground hot springs. Chemical analyses revealed no toxic compounds minerals, poisonous gases, or radon accumulation. radiation levels also be safe. Conclusions: Physical, chemical, biological research demonstrated risk factors health Cave. No spoilage human pathogenic bacteria found. fungi detected. suggest could promising location reserves. Keywords: cave), constructions, reserve safety, spoilage,

Язык: Английский

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Ohmic, ultraviolet, and infrared heating-assisted extraction of bioactive compounds

Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 143 - 170

Опубликована: Ноя. 1, 2024

Язык: Английский

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Interaction of probiotic activity, antioxidative capacity, and gamma‐ amino butyric acid ( GABA ) in chestnut milk‐fortified yogurt

Journal of Food Processing and Preservation, Год журнала: 2022, Номер 46(12)

Опубликована: Окт. 28, 2022

Abstract As a novel functional dairy product, yogurt was produced from mixtures of skimmed milk and chestnut using probiotic culture. The survival bacteria, antioxidant capacity, total phenolic content, gamma‐ amino butyric acid (GABA) content the samples were determined. Results showed that sample with 100% contained higher dry matter, fat, carbohydrate, caloric value lower vitamin C, E contents. Samples had high K, Ca, P, Na, Na values. Probiotic bacteria capable growing well over recommended therapeutic in fortified milk. excellent 2,2′‐azinobis‐(3‐ethylbenzothiazoline‐6‐sulfonic acid) 2, 2′‐diphenyl‐1‐picrylhydrazyl radicals scavenging activities as ferric reducing power. However, it found ratio increased, capacity values increased. GABA varied 0.31 to 2.43 mg 100 g −1 . According hierarchical cluster analysis, 20%, 30%, 40%, 50% similar compositional properties. Novelty impact statement objective present study compare nutritional, microbiological, antioxidative properties yogurts manufactured Based on findings this study, fortification milk, general, positive effects nutritional yogurt. describes could be considered potential source compounds GABA. Chestnut milk‐fortified products contributed ensure maximum benefits these good alternative for consumers demanding healthier foods.

Язык: Английский

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