Sporadic detection of vaccine-derived poliovirus type 2 using next-generation sequencing in Canadian wastewater in August of 2022 DOI Creative Commons
G. Seo,

Russell Mandes,

Nathan Wright

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Апрель 15, 2025

Abstract In July 2022, an unvaccinated young adult living in Rockland County, New York became paralyzed due to a vaccine-derived poliovirus type 2 (VDPV2) infection that was internationally transmitted. Wastewater surveillance State uncovered VDPV2 neighboring counties, showing silent community spread. These communities have strong epidemiological links some vaccine-hesitant Canada, spurring the need monitor these populations for potential importation. At time, Canada did not established wastewater method. We initiated this study apply molecular methods detect and establish capabilities Canada. sequence confirmed one detection on August 30th, 2022 using both viral isolation direct methods. Subsequent retrospective prospective sampling initiated, resulting another of overlapping catchment area collected 27th, 2022. Both detections were genetically linked clinical case. No cases poliomyelitis detected during study. The sporadic Canadian supports travel-related shedding event without transmission. Furthermore, we show method is sensitive confirm samples.

Язык: Английский

It won’t end with COVID: Countering the next phase of American antivaccine activism 2025–29 DOI Creative Commons
Peter J. Hotez

PLOS Global Public Health, Год журнала: 2025, Номер 5(1), С. e0004020 - e0004020

Опубликована: Янв. 8, 2025

is a co-inventor on non-revenue generating patents for neglected tropical diseases owned by Baylor College of Medicine (BCM).He also COVID-19 recombinant protein vaccine technology BCM that was

Язык: Английский

Процитировано

4

Community case study: an academia-industry-government partnership that monitors and predicts outbreaks in Tri-County Detroit area since 2017 DOI Creative Commons
Irene Xagoraraki, Liang Zhao, Yabing Li

и другие.

Frontiers in Public Health, Год журнала: 2025, Номер 12

Опубликована: Янв. 28, 2025

The Tri-County Detroit Area (TCDA) is the 12th most populous metropolitan area in United States with over three million people. Multiple communicable diseases are endemic TCDA. In 2017, to explore innovative methods that may provide early warnings of outbreaks affecting populations TCDA, an exploratory partnership was funded by a U.S. National Science Foundation Early-concept Grant for Exploratory Research (EAGER) began. Since project team including College Engineering at Michigan State University (MSU), City Detroit, Great Lakes Water Authority (GLWA), industry, and local government health departments, has been testing municipal wastewater from TCDA survey predict surges area. This ongoing effort started years before wastewater-based epidemiology became widespread method public practice, due COVID-19 pandemic, now supported Centers Disease Control Prevention (CDC). work led significant breakthroughs field surveillance/wastewater epidemiology. results our surveillance efforts used assist departments their understanding response issues facilitating messaging awareness, targeted clinical testing, increased vaccination efforts. Our data available methodological advancements published have other communities nationwide beyond. paper describes partnership, lessons learned, achievements, provides look into future. successful implementations advocate importance frequent communications interactions within idea generations each stakeholder decision-making, maintenance scientific rigor, ethical more.

Язык: Английский

Процитировано

0

Evaluation of the Enterovirus serotype monitoring approach for wastewater surveillance of hand foot and mouth disease using secondary epidemiological surveillance data DOI Creative Commons
Sadhana Shrestha, Bikash Malla, Eiji Haramoto

и другие.

The Science of The Total Environment, Год журнала: 2025, Номер 969, С. 178896 - 178896

Опубликована: Фев. 26, 2025

Язык: Английский

Процитировано

0

Wastewater surveillance as a tool for understanding West Nile virus transmission and distribution in Oklahoma DOI
Katrin Gaardbo Kuhn, Kristen Shelton, Gilson J. Sanchez

и другие.

The Science of The Total Environment, Год журнала: 2025, Номер 983, С. 179707 - 179707

Опубликована: Май 21, 2025

Язык: Английский

Процитировано

0

Sporadic detection of vaccine-derived poliovirus type 2 using next-generation sequencing in Canadian wastewater in August of 2022 DOI Creative Commons
G. Seo,

Russell Mandes,

Nathan Wright

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Апрель 15, 2025

Abstract In July 2022, an unvaccinated young adult living in Rockland County, New York became paralyzed due to a vaccine-derived poliovirus type 2 (VDPV2) infection that was internationally transmitted. Wastewater surveillance State uncovered VDPV2 neighboring counties, showing silent community spread. These communities have strong epidemiological links some vaccine-hesitant Canada, spurring the need monitor these populations for potential importation. At time, Canada did not established wastewater method. We initiated this study apply molecular methods detect and establish capabilities Canada. sequence confirmed one detection on August 30th, 2022 using both viral isolation direct methods. Subsequent retrospective prospective sampling initiated, resulting another of overlapping catchment area collected 27th, 2022. Both detections were genetically linked clinical case. No cases poliomyelitis detected during study. The sporadic Canadian supports travel-related shedding event without transmission. Furthermore, we show method is sensitive confirm samples.

Язык: Английский

Процитировано

0