Clinical and Research Journal in Internal Medicine,
Год журнала:
2023,
Номер
4(1), С. 404 - 417
Опубликована: Май 25, 2023
Alzheimer’s
disease
is
a
common
neurodegenerative
that
affect
elderly
and
it
became
serious
global
burden
for
years.
Despite
many
studies
have
been
performed,
an
effective
cure
was
still
not
be
found.
Therefore,
necessary
to
only
focus
on
curative
methods
but
also
preventive
with
modifiable
risk
factors
underlying
disease,
example
lifestyle
metabolic
as
potential
approach
in
prevention
the
future.
The
excessive
dietary
sugar
intake
has
suggested
factor
of
diseases
such
cognitive
impairment
disease.
It
may
promote
declines
through
some
pathways
induce
alteration
gut
microbiomes,
metabolism
immune
system.
These
abnormal
processes
evoke
amyloid
β
plaque
formation
neurofibrillary
tangles
brain
cells
effect
chronic
inflammation.
Chronic
inflammation
widely
studied
hallmark
pathology.
correlation
between
cognitive,
specifically
will
summarized.
Brain Sciences,
Год журнала:
2023,
Номер
14(1), С. 8 - 8
Опубликована: Дек. 21, 2023
Wear
and
tear
are
natural
processes
for
all
living
non-living
bodies.
All
cells
organisms
metabolically
active
to
generate
energy
their
routine
needs,
including
survival.
In
the
process,
exposed
oxidative
load,
metabolic
waste,
bye-products.
an
organ,
non-neuronal
divide
replenish
lost
or
damaged
cells;
however,
as
neuronal
normally
do
not
divide,
they
need
special
feature(s)
protection,
survival,
sustenance
normal
functioning
of
brain.
The
neurons
grow
branch
axons
dendrites,
which
contribute
formation
synapses
with
near
far
neurons,
basic
scaffold
complex
brain
functions.
It
is
necessary
that
one
more
instinct
physiological
process(es)
(functions)
likely
protection
maintenance
synapses.
known
rapid
eye
movement
sleep
(REMS),
autonomic
behavior,
maintains
learning
memory
its
loss
causes
dysfunctions.
this
review
we
correlate
role
REMS
in
synaptogenesis,
consolidation,
degeneration.
Further,
a
mechanism
action,
will
show
noradrenaline
(NA)
at
low
level,
protects
from
damage
growth
synaptogenesis.
However,
upon
loss,
level
NA
increases,
withdraws
apoptosis
neurons.
We
propose
latter
possibly
associated
neurodegenerative
diseases
symptoms.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 1, 2024
Systemic
inflammation
has
been
implicated
in
the
development
and
progression
of
neurodegenerative
conditions
such
as
cognitive
impairment
dementia.
Recent
clinical
studies
indicate
an
association
between
sepsis,
endothelial
dysfunction,
decline.
However,
investigations
role
therapeutic
potential
cerebral
microvasculature
systemic
inflammation-induced
dysfunction
have
limited
by
lack
standardized
experimental
models
for
evaluating
alterations
cognition
induced
inflammatory
response.
Herein,
we
validated
a
mouse
model
endotoxemia
that
recapitulates
key
pathophysiology
related
to
sepsis-induced
including
induction
acute
hyperinflammatory
response,
blood-brain
barrier
(BBB)
leakage,
neurovascular
inflammation,
memory
after
recovery
from
In
phase,
identified
novel
molecular
(e.g.
upregulation
plasmalemma
vesicle
associated
protein,
driver
permeability,
pro-coagulant
plasminogen
activator
inhibitor-1,
PAI-1)
functional
perturbations
(i.e.,
albumin
small
molecule
BBB
leakage)
along
with
neuroinflammation.
Remarkably,
elevated
levels
PAI-1,
intra/perivascular
fibrin/fibrinogen
deposition
microglial
activation
persisted
1
month
sepsis.
We
also
highlight
neuronal
relevance
following
changes
neurofilament
phosphorylation
decreases
postsynaptic
density
protein
95
brain-derived
neurotrophic
factor
suggesting
diffuse
axonal
injury,
synapse
degeneration
impaired
neurotrophism.
Our
study
serves
support
future
mechanistic
sepsis-associated
identify
targets
this
devastating
condition.
Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Сен. 27, 2023
Abstract
Introduction:
Age-related
cognitive
impairment
is
a
common
issue
that
frequently
brought
on
by
oxidative
stress
and
neurodegeneration
in
the
brain.
D-gal
sugar
moiety
has
been
linked
to
aging
disorders.
This
disease's
prevalence
expected
rise
linearly
2050.
Material
&
methods:
Benincasa
hispida
,
commonly
known
as
wax
gourd
or
winter
melon,
widely
consumed
vegetable
with
various
medicinal
properties.
it
belongs
family
of
Cucurbitaceae.
study
evaluates
neuroprotective
role
hydro-ethanolic
seed
extract
(BH)
against
D-gal-induced
rats.
Healthy
male
rats
were
divided
into
six
groups:
The
control
group
received
normal
saline,
donepezil
(2
mg/kg
b.w.t.,
i.p.);
(300
+BH
(150
o.p.);
BH
(250
b.wt.
Results
discussion:
Behavioural,
brain
biochemical,
histopathological
changes
assessed
after
treatment.
results
behavioral
depicted
significantly
reduces
spontaneous
alternation
locomotor
activity,
indicating
impairment.
Biochemical
studies
showed
increases
rat
brains.
Histopathological
disturbs
architecture
hippocampal
cortical
cells,
degeneration
these
areas.
co-treatment
for
42
days
attenuated
behavioral,
neuroanatomic
damages
caused
D-gal;
markedly
suppressed
AChE
activity
maintained
cellular
Conclusion:
Thus,
this
shows
can
protect
from
adverse
effects
(e.g.,
memory
loss
impairment)
modulating
stress.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2022,
Номер
unknown
Опубликована: Ноя. 15, 2022
Abstract
Accumulation
of
hyperphosphorylated
tau
in
the
locus
coeruleus
(LC)
is
a
ubiquitous
feature
prodromal
Alzheimer’s
disease
(AD),
and
LC
neurons
degenerate
as
AD
progresses.
Tau-mediated
dysfunction
may
contribute
to
early
neuropsychiatric
symptoms,
while
loss
integrity
associated
with
conversion
cognitive
impairment.
Hyperphosphorylated
alters
firing
rates
other
brain
regions,
but
its
effects
on
have
not
been
described.
The
purpose
this
study
was
characterize
changes
properties
when
they
are
only
cells
containing
tau,
well
later
β-amyloid
(Aβ)
pathology
abundant
forebrain.
Single
unit
activity
recorded
from
anesthetized
wild-type
(WT)
TgF344-AD
rats,
which
carry
APP/PS1
transgene.
Similar
human
AD,
these
rats
develop
(at
6
months)
prior
Aβ
or
forebrain
regions
12-15
months).
At
baseline,
were
hypoactive
at
both
ages
compared
WT
littermates,
showed
elevated
spontaneous
bursting
properties,
particularly
younger
animals.
Differences
footshock-evoked
depended
age,
6-month
demonstrating
aspects
hyperactivity,
aged
transgenic
showing
hypoactivity
relative
WT.
Tau-induced
alterations
pathophysiology
hyperactivity
followed
by
contributing
These
results
support
further
investigation
into
stage-dependent
noradrenergic
interventions
for
AD.
Highlights
Recorded
rat
model
(AD)
endogenous
akin
6-
15-month
had
reduced
tonic
hyperactive
response
footshock
neuron
symptoms
Clinical and Research Journal in Internal Medicine,
Год журнала:
2023,
Номер
4(1), С. 404 - 417
Опубликована: Май 25, 2023
Alzheimer’s
disease
is
a
common
neurodegenerative
that
affect
elderly
and
it
became
serious
global
burden
for
years.
Despite
many
studies
have
been
performed,
an
effective
cure
was
still
not
be
found.
Therefore,
necessary
to
only
focus
on
curative
methods
but
also
preventive
with
modifiable
risk
factors
underlying
disease,
example
lifestyle
metabolic
as
potential
approach
in
prevention
the
future.
The
excessive
dietary
sugar
intake
has
suggested
factor
of
diseases
such
cognitive
impairment
disease.
It
may
promote
declines
through
some
pathways
induce
alteration
gut
microbiomes,
metabolism
immune
system.
These
abnormal
processes
evoke
amyloid
β
plaque
formation
neurofibrillary
tangles
brain
cells
effect
chronic
inflammation.
Chronic
inflammation
widely
studied
hallmark
pathology.
correlation
between
cognitive,
specifically
will
summarized.
