Taming neuroinflammation in Alzheimer's disease: The protective role of phytochemicals through the gut−brain axis
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
178, С. 117277 - 117277
Опубликована: Авг. 9, 2024
Язык: Английский
Advancements and challenges in mouse models of Alzheimer’s disease
Trends in Molecular Medicine,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 1, 2024
Язык: Английский
Two- and Three-Dimensional In Vitro Models of Parkinson’s and Alzheimer’s Diseases: State-of-the-Art and Applications
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(2), С. 620 - 620
Опубликована: Янв. 13, 2025
In
vitro
models
play
a
pivotal
role
in
advancing
our
understanding
of
neurodegenerative
diseases
(NDs)
such
as
Parkinson’s
and
Alzheimer’s
disease
(PD
AD).
Traditionally,
2D
cell
cultures
have
been
instrumental
elucidating
the
cellular
mechanisms
underlying
these
diseases.
Cultured
cells
derived
from
patients
or
animal
provide
valuable
insights
into
pathological
processes
at
level.
However,
they
often
lack
native
tissue
environment
complexity,
limiting
their
ability
to
fully
recapitulate
features.
contrast,
3D
offer
more
physiologically
relevant
platform
by
mimicking
brain
architecture.
These
can
incorporate
multiple
types,
including
neurons,
astrocytes,
microglia,
creating
microenvironment
that
closely
resembles
brain’s
complexity.
Bioengineering
approaches
allow
researchers
better
replicate
cell–cell
interactions,
neuronal
connectivity,
disease-related
phenotypes.
Both
advantages
limitations.
While
simplicity
scalability
for
high-throughput
screening
basic
processes,
enhanced
physiological
relevance
Integrating
findings
both
model
systems
NDs,
ultimately
aiding
development
novel
therapeutic
strategies.
Here,
we
review
existing
study
PD
AD.
Язык: Английский
Octodon degus laboratory colony management principles and methods for behavioral analysis for Alzheimer’s disease neuroscience research
Frontiers in Aging Neuroscience,
Год журнала:
2025,
Номер
16
Опубликована: Янв. 20, 2025
The
Chilean
degu
(
Octodon
degus
)
is
a
medium
sized,
long-lived
rodent
with
traits
that
make
them
natural
model
for
neuroscience
research.
Their
social
behaviors,
diurnality,
and
extended
developmental
time
course,
when
compared
to
other
rodents,
useful
behavioral,
chronobiology,
Lab-kept
have
long
lifespan
(5–8
years)
may
naturally
develop
age-related
diseases
resemble
Alzheimer’s
disease.
While
there
significant
interest
in
using
the
research,
including
aging
disease
studies,
laboratory
management
methods
research
are
currently
not
standardized.
This
lack
of
standardization
potentially
impacts
study
reproducibility
makes
it
difficult
compare
results
between
different
laboratories.
Degus
require
species-specific
housing
handling
reflect
their
ecology,
life
history,
group-living
characteristics.
Here
we
introduce
major
principles
ethological
considerations
colony
husbandry.
We
provide
clear
instructions
on
practices
necessary
maintaining
healthy
robust
towards
conducting
reproducible
studies.
also
report
detailed
procedures
methodical
information
Apoe
genotyping
ethologically
relevant
burrowing
behavioral
tasks
settings.
Язык: Английский
Multidimensional insights into squalene epoxidase drug development: in vitro mechanisms, in silico modeling, and in vivo implications
Expert Opinion on Therapeutic Targets,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 30, 2025
Squalene
epoxidase
(SQLE)
is
a
pivotal
enzyme
in
sterol
biosynthesis,
catalyzing
the
conversion
of
squalene
to
2,3-oxidosqualene.
Beyond
its
core
role
cholesterol
homeostasis,
SQLE
implicated
cancer,
hypercholesterolemia,
and
fungal
infections,
positioning
it
as
valuable
therapeutic
target.
We
conducted
comprehensive
literature
search
across
primary
databases
gather
vitro,
silico,
vivo
evidence
on
SQLE.
This
review
explores
enzyme's
structural
functional
features,
including
substrate
specificity
catalytic
mechanisms,
examines
inhibitor
interactions.
Computational
methods
predict
-
dynamics,
guiding
drug
design,
while
investigations
clarify
SQLE's
metabolic
disorders
tumorigenesis.
Challenges
include
resistance
study
discrepancies,
but
emerging
technologies,
such
cryo-electron
microscopy
CRISPR
editing,
offer
new
avenues
for
deeper
exploration.
an
underexplored
yet
promising
target,
with
particular
relevance
oxidative
stress,
ferroptosis,
gut
microbiota
research.
Overcoming
current
barriers
through
advanced
technologies
multidisciplinary
strategies
could
propel
SQLE-targeted
treatments
into
clinical
practice,
supporting
precision
medicine
broader
translational
applications.
Язык: Английский
Alzheimer’s Disease: Cellular and Pharmacological Aspects
Geriatrics,
Год журнала:
2024,
Номер
9(4), С. 86 - 86
Опубликована: Июнь 22, 2024
Alzheimer's
disease
was
described
more
than
100
years
ago
and
despite
the
fact
that
several
molecules
are
being
tested
for
its
treatment,
which
in
phase
III
trials,
continues
to
progress.
The
main
problem
is
these
function
properly
healthy
neurons,
while
neuronal
pathology
includes
plasma
membrane
disruption,
malfunction
of
various
organelles,
hyperphosphorylation
Tau
amyloid
plaques.
objective
this
article
discussion
a
restoration
therapy,
where
designed
treatment
would
probably
be
effective,
quality
life
people
better.
Язык: Английский
Advancing Alzheimer’s Disease Modelling by Developing a Refined Biomimetic Brain Microenvironment for Facilitating High-Throughput Screening of Pharmacological Treatment Strategies
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
26(1), С. 241 - 241
Опубликована: Дек. 30, 2024
Alzheimer’s
disease
(AD)
poses
a
significant
worldwide
health
challenge,
requiring
novel
approaches
for
improved
models
and
treatment
development.
This
comprehensive
review
emphasises
the
systematic
development
improvement
of
biomimetic
brain
environment
to
address
shortcomings
existing
AD
enhance
efficiency
screening
potential
drug
treatments.
We
identify
drawbacks
in
traditional
emphasise
necessity
more
physiologically
accurate
systems
through
an
in-depth
analysis
current
literature.
aims
study
advanced
model
that
accurately
replicates
key
pathophysiological
aspects
using
cutting-edge
biomaterials
microenvironment
design.
Incorporating
biomolecular
elements
like
Tau
proteins
beta-amyloid
(Aβ)
plaques
improve
accuracy
illustrating
mechanisms.
The
expected
results
involve
creating
solid
foundation
high-throughput
with
enhanced
scalability,
translational
significance,
possibility
speeding
up
discovery.
Thus,
this
fills
gaps
modelling
shows
precise
efficient
treatments
AD.
Язык: Английский