Clinical Characteristics of Human Mpox (Monkeypox) in 2022: A Systematic Review and Meta-Analysis

Pathogens, Год журнала: 2023, Номер 12(1), С. 146 - 146

Опубликована: Янв. 15, 2023

Since May 2022, large numbers of human mpox (previously known as monkeypox) cases have been reported in non-endemic regions. We conducted a systematic review and meta-analysis to elucidate clinical characteristics the current outbreak. Our were undertaken according PRISMA MOOSE guidelines. searched PubMed, EMBASE, Web Science for publications between 1 January 11 November 2022. Random-effects models used pool results. Heterogeneity was assessed using I2. This study is registered with PROSPERO, CRD42022355590. Skin lesions (95.2%, 95% CI [93.3–96.9%]), fever (58.4%, [54.9–61.8%]) lymphadenopathy (53.0%, [48.7–57.3%]) most common symptoms. The dermatological manifestations anogenital (65.7%, [57.8–73.0%]), inguinal (46.8%, [40.6–53.0%]). There no differences symptoms including malaise, fever, headache, genital, anal, oropharyngeal HIV infection status. Median age patients varied from 15 57.5 years (median, 35 years). median proportion men who had sex (MSM) 100.0% (20.6–100.0%). recent sexual exposure 99.2% (14.3–100.0%). PLHIV 42.2% (0.0–100.0%). lesions, lymphadenopathy, Existing guidelines should be updated reflect these groups at highest risk infection, MSM particular.

Язык: Английский

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Epidemiologic Situation of HIV and Monkeypox Coinfection: A Systematic Review

Vaccines, Год журнала: 2023, Номер 11(2), С. 246 - 246

Опубликована: Янв. 22, 2023

The most recent monkeypox (Mpox) outbreak is mostly affecting men who have sex with (MSM) participate in high-risk sexual behaviors, which typically the case among human immunodeficiency virus (HIV) carriers, according to clinical and epidemiological statistics. objective of this research determine situation HIV smallpox co-infection. Until 1 October 2022, a thorough evaluation literature was conducted utilizing databases PubMed, Embase, Scopus, Web Science. Studies were evaluated based on criteria for selection. Fifty-three studies met selection criteria. A total 6345 confirmed cases recorded, 40.32% (n = 2558) these also had In addition, 51.36% 3259) (91.44%; n 5802), whose ages ranged from 18 71 years, exhibited MSM-specific behaviors. Co-infection two viruses can be especially dangerous because it exacerbate symptoms both diseases make them more difficult treat. People are vulnerable certain infections, including monkeypox, their immune systems weakened. Therefore, important that they take measures prevent infection, such as avoiding contact infected animals, risky maintaining good hygiene.

Язык: Английский

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Severe monkeypox-virus infection in undiagnosed advanced HIV infection

Infection, Год журнала: 2022, Номер 50(6), С. 1633 - 1634

Опубликована: Авг. 15, 2022

Язык: Английский

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Mpox and HIV: a Narrative Review

Current HIV/AIDS Reports, Год журнала: 2023, Номер 20(4), С. 261 - 269

Опубликована: Май 13, 2023

Язык: Английский

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Demographic, Epidemiologic, and Clinical Characteristics of Human Monkeypox Disease Pre- and Post-2022 Outbreaks: A Systematic Review and Meta-Analysis

Biomedicines, Год журнала: 2023, Номер 11(3), С. 957 - 957

Опубликована: Март 20, 2023

(1) Background: In early May 2022, an increasing number of human monkeypox (mpox) cases were reported in non-endemic disparate regions the world, which raised concerns. Here, we provide a systematic review and meta-analysis mpox-confirmed patients presented peer-reviewed publications over 10 years before during 2022 outbreak from demographic, epidemiological, clinical perspectives. (2) Methods: A search was performed for relevant studies published Pubmed/Medline, Embase, Scopus, Google Scholar 1 January 2012 up to 15 February 2023. Pooled frequencies with 95% confidence intervals (CIs) assessed using random or fixed effect model due estimated heterogeneity true sizes. (3) Results: Out 10,163 articles, 67 met inclusion criteria, 31 cross-sectional included meta-analysis. Animal-to-human transmission dominant pre-2022 (61.64%), but almost all post-2022 had history contact, especially sexual contact. The pooled frequency MSM individuals 93.5% (95% CI 91.0-95.4, I2: 86.60%) only studies. male gender predominant both pre- outbreaks, mean age confirmed 29.92 (5.77-41, SD: 9.38). most common manifestations rash, fever, lymphadenopathy, malaise/fatigue. Proctalgia/proctitis (16.6%, 10.3-25.6, 97.76) anal/perianal lesions (39.8%, 30.4-49.9, 98.10) unprecedented outbreak, not described before. Genitalia involvement more mpox (55.6%, 51.7-59.4, 88.11). (4) Conclusions: There are speculations about possibility changes pathogenic properties virus. It seems that experience milder disease fewer rashes lower mortality rates. Moreover, vast majority managed on outpatient basis. Our study could serve as basis ongoing investigations identify different aspects previous outbreaks compare them current ones.

Язык: Английский

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Estimating the relative importance of epidemiological and behavioural parameters for epidemic mpox transmission: a modelling study

BMC Medicine, Год журнала: 2024, Номер 22(1)

Опубликована: Июль 18, 2024

Abstract Background Many European countries experienced outbreaks of mpox in 2022, and there was an outbreak 2023 the Democratic Republic Congo. There were many apparent differences between these previous mpox; recent observed men who have sex with after sexual encounters at common events, whereas earlier a wider population no identifiable link to contacts. These meant that data from could not reliably be used parametrise infectious disease models during 2022 outbreaks, modelling efforts hampered by uncertainty around key transmission immunity parameters. Methods We developed stochastic, discrete-time metapopulation model for allowed non-sexual implementation non-pharmaceutical interventions, specifically contact tracing pre- post-exposure vaccinations. calibrated case Berlin Sobol sensitivity analysis identify parameters is especially sensitive to. also briefly analysed effectiveness interventions various efficacy Results found variance probabilities due both had large effect on model, as did level conferred smallpox vaccination. Furthermore, number pre-exposure vaccinations offered dominant contributor dynamics men. If available, accuracy timeliness impact model. Conclusions Our results are valuable guiding epidemiological studies parameter ascertainment identifying factors success interventions.

Язык: Английский

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Características epidemiológicas e clínicas dos casos de monkeypox no Brasil em 2022: estudo transversal

Epidemiologia e Serviços de Saúde, Год журнала: 2022, Номер 31(3)

Опубликована: Янв. 1, 2022

to describe epidemiological and clinical characteristics of monkeypox (MPX) in Brazil, from the identification first case, on June 7, 2022, Epidemiological Week (EW) 39, ending October 1, 2022.this was a descriptive study cases notified Ministry Health; trends were analyzed based number confirmed probable per EW; also described according demographic variables.out 31,513 notifications, 23.8% confirmed; 91.8% male; 70.6% cis men; median age 32 years. Fever (58.0%), adenomegaly (42.4%), headache (39.9%) rash (37.0%) most frequent symptoms; 27.5% reported being immunosuppressed, 34.6% living with HIV 10.5% had sexually transmitted infection; three deaths recorded.the MPX case profile similar that other countries; surveillance actions must be strengthened control outbreak.descrever características epidemiológicas e clínicas da no Brasil desde identificação do primeiro caso, em 7 de junho até semana epidemiológica (SE) encerrada 1º outubro 2022.estudo descritivo dos casos notificados ao Ministério Saúde; as tendências foram analisadas sobre o número confirmados prováveis, por SE; os descritos segundo variáveis demográficas clínicas.das 33.513 notificações, 23,8% confirmadas, 91,8% eram sexo masculino 70,6% homens com idade mediana anos; febre (58,0%), adenomegalia (42,4%), cefaleia (39,9%) erupções (37,0%) sintomas mais frequentes; 27,5% declararam ser imunossuprimidos, 34,6% viviam 10,5% possuíam infecção sexualmente transmissível; três óbitos registrados.o perfil foi semelhante outros países; ações vigilância devem reforçadas para controle surto.Describir las y la viruela del mono en Brasil, identificación primer el junio hasta finalizando 1° octubre 2022.Las tendencias los al Ministerio Salud se analizaron como probables, SE. Los describieron según variables clínicas.se confirmaron notificaciones un 23,8%; masculino; hombres cis; con edad promedio años. Fiebre cefalea exantema fueron síntomas más frecuentes. Un declaró estar inmunodeprimido, vivía VIH tenía alguna infección transmisión sexual. Se registraron 3 muertes.El fue otros países. deben reforzar acciones vigilancia controlar brote.

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Monkeypox Outbreak in Peru

Medicina, Год журнала: 2023, Номер 59(6), С. 1096 - 1096

Опубликована: Июнь 6, 2023

Monkeypox (Mpox) is a zoonotic disease caused by the Orthopoxvirus monkeypox virus (MPXV). Since 1970, outbreaks of MPXV have occurred in several Sub-Saharan African countries. However, from May 2022 to April 2023, recent Mpox countries outside Africa, and these cases quickly spread over 100 non-endemic on all continents. Most were found region Americas Europe region. In Latin America, highest all-age rates per million inhabitants Peru, Colombia, Chile, Brazil. Given its global impact, was declared as an international Public Health Emergency WHO July 2022. infection disproportionately affects men who sex with members HIV-infected population. Vaccination current strategy for controlling preventing high-risk groups. this context, Peru has fourth-highest number America faces significant challenges control. Because this, review, we discuss epidemiology, public health indicators, prevention outbreak so that authorities can join forces control transmission.

Язык: Английский

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Mpox outbreak 2022: an overview of all cases reported to the Cologne Health Department

Infection, Год журнала: 2023, Номер 51(5), С. 1369 - 1381

Опубликована: Фев. 14, 2023

Язык: Английский

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Erregerlexikon: Mpox-Viren

Deleted Journal, Год журнала: 2025, Номер 02(02), С. 137 - 151

Опубликована: Апрель 23, 2025

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