Advancements and Challenges of R-loops in Cancers: Biological Insights and Future Directions

Cancer Letters, Год журнала: 2024, Номер 610, С. 217359 - 217359

Опубликована: Ноя. 27, 2024

Язык: Английский

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RNA methylation modifications in neurodegenerative diseases: Focus on their enzyme system

Journal of Advanced Research, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Neurodegenerative diseases (NDs) constitute a significant public health challenge, as they are increasingly contributing to global mortality and morbidity, particularly among the elderly population. Pathogenesis of NDs is intricate multifactorial. Recently, post-transcriptional modifications (PTMs) RNA, with particular focus on mRNA methylation, have been gaining increasing attention. At present, several regulatory genes associated methylation identified closely neurodegenerative disorders. This review aimed summarize RNA enzymes system, including writer, reader, eraser proteins delve into their functions in central nervous system (CNS), hoping open new avenues for exploring mechanisms therapeutic strategies NDs. studies highlighted critical role development function CNS, abnormalities this process may contribute brain damage NDs, aberrant expression involved has implicated onset

Язык: Английский

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Biological functions of 5-methylcytosine RNA-binding proteins and their potential mechanisms in human cancers

Frontiers in Oncology, Год журнала: 2025, Номер 15

Опубликована: Фев. 7, 2025

The 5-methylcytosine (m5C) modification is a crucial epigenetic RNA modification, which involved in the post-transcriptional regulation of genes. It plays an important role various biological processes, including cell metabolism, growth, apoptosis, and tumorigenesis. By affecting proliferation, migration, invasion, drug sensitivity tumor cells, m5C methylation vital part initiation progression tumors closely associated with poor prognosis. m5C-related proteins are categorized into three functional groups: methyltransferases (m5C writers), demethylases erasers), methyl-binding readers). This paper introduces several common methodologies for detecting methylation; reviews molecular structure functions readers, ALYREF, YBX1, YBX2, RAD52, YTHDF2, FMRP, SRSF2. further summarizes their roles regulatory mechanisms tumors, offering novel targets insights treatment.

Язык: Английский

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Recent insights into RNA m5C methylation modification in hepatocellular carcinoma

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Год журнала: 2024, Номер unknown, С. 189223 - 189223

Опубликована: Ноя. 1, 2024

Язык: Английский

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Significant roles of RNA 5-methylcytosine methylation in cancer

Cellular Signalling, Год журнала: 2024, Номер 126, С. 111529 - 111529

Опубликована: Ноя. 28, 2024

Язык: Английский

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