Significant roles of RNA 5-methylcytosine methylation in cancer DOI
Ning Lou, Xinyu Gu, Li Fu

et al.

Cellular Signalling, Journal Year: 2024, Volume and Issue: 126, P. 111529 - 111529

Published: Nov. 28, 2024

Language: Английский

Advancements and Challenges of R-loops in Cancers: Biological Insights and Future Directions DOI
Dengxiong Li, Fanglin Shao, Xinrui Li

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 610, P. 217359 - 217359

Published: Nov. 27, 2024

Language: Английский

Citations

5
RNA methylation modifications in neurodegenerative diseases: Focus on their enzyme system DOI Creative Commons
Lu Liu, Yujia Zhao, Feng Zhang

et al.

Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Neurodegenerative diseases (NDs) constitute a significant public health challenge, as they are increasingly contributing to global mortality and morbidity, particularly among the elderly population. Pathogenesis of NDs is intricate multifactorial. Recently, post-transcriptional modifications (PTMs) RNA, with particular focus on mRNA methylation, have been gaining increasing attention. At present, several regulatory genes associated methylation identified closely neurodegenerative disorders. This review aimed summarize RNA enzymes system, including writer, reader, eraser proteins delve into their functions in central nervous system (CNS), hoping open new avenues for exploring mechanisms therapeutic strategies NDs. studies highlighted critical role development function CNS, abnormalities this process may contribute brain damage NDs, aberrant expression involved has implicated onset

Language: Английский

Citations

0
Biological functions of 5-methylcytosine RNA-binding proteins and their potential mechanisms in human cancers DOI Creative Commons
Tingting Zhao, Zhe Zhang, Zhuo Chen

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: Feb. 7, 2025

The 5-methylcytosine (m5C) modification is a crucial epigenetic RNA modification, which involved in the post-transcriptional regulation of genes. It plays an important role various biological processes, including cell metabolism, growth, apoptosis, and tumorigenesis. By affecting proliferation, migration, invasion, drug sensitivity tumor cells, m5C methylation vital part initiation progression tumors closely associated with poor prognosis. m5C-related proteins are categorized into three functional groups: methyltransferases (m5C writers), demethylases erasers), methyl-binding readers). This paper introduces several common methodologies for detecting methylation; reviews molecular structure functions readers, ALYREF, YBX1, YBX2, RAD52, YTHDF2, FMRP, SRSF2. further summarizes their roles regulatory mechanisms tumors, offering novel targets insights treatment.

Language: Английский

Citations

0
Recent insights into RNA m5C methylation modification in hepatocellular carcinoma DOI Creative Commons
Danyang Li, Yanyan Liu,

Guang Yang

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2024, Volume and Issue: unknown, P. 189223 - 189223

Published: Nov. 1, 2024

Language: Английский

Citations

0
Significant roles of RNA 5-methylcytosine methylation in cancer DOI
Ning Lou, Xinyu Gu, Li Fu

et al.

Cellular Signalling, Journal Year: 2024, Volume and Issue: 126, P. 111529 - 111529

Published: Nov. 28, 2024

Language: Английский

Citations

0