Vitamin D Attenuates Non-Alcoholic Fatty Liver Disease in High-Fat Diet-Induced Obesity Murine Model DOI Creative Commons
Sook In Chung, Lin Liang, Heejae Han

и другие.

Yonsei Medical Journal, Год журнала: 2024, Номер 66(2), С. 75 - 75

Опубликована: Дек. 10, 2024

Obesity and metabolic syndrome are acknowledged as key factors contributing to the development of non-alcoholic fatty liver disease (NAFLD). Vitamin D (VitD) is a multifaceted secosteroid hormone known for its anti-fibrotic anti-inflammatory properties, with deficiency often linked obesity. Our study aimed investigate whether VitD supplementation could mitigate pathology associated NAFLD. The NAFLD model was developed by subjecting male C57BL/6 mice high-fat diet (HFD) 14 weeks. These were supplemented through intraperitoneal injection at dosage 7 µg/kg, administered three times per week HFD resulted in deficiency, insulin resistance, increased weight. It elevated serum levels aminotransferases triglyceride, ultimately leading steatohepatitis fibrosis. This exhibited transforming growth factor (TGF)-β1, pro-inflammatory cytokines, HNF4α transcription factors, reactive oxygen species (ROS), renin-angiotensin system activity, epithelial-mesenchymal transitions (EMT) within liver. Supplementation recovery weight, improvement histologic features steatohepatitis, reduction alanine triglyceride induced HFD. Additionally, it mitigated HFD-induced over-expressions TGF-β1 fibrosis-related genes, along cytokines ROS. Notably, no adverse effect found due this model. ameliorates obesity-induced pathways. emerges potentially safe, cost-effective, direct treatment approach patients dealing obesity or dysfunction.

Язык: Английский

Updates in Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) in Children DOI
Kushila Rupasinghe, Jonathan Hind, Robert Hegarty

и другие.

Journal of Pediatric Gastroenterology and Nutrition, Год журнала: 2023, Номер 77(5), С. 583 - 591

Опубликована: Авг. 18, 2023

The obesity epidemic is one of the major health concerns 21st century. Nonalcoholic fatty liver disease (NAFLD) linked with increased adiposity associated obesity. NAFLD has become most frequent cause chronic in adults and children worldwide. Metabolic dysfunction-associated (MAFLD) also known as pediatric (PeFLD) type 2 begun to supersede preferred nomenclature population. Evidence suggests etiology MAFLD multifactorial, related complex interplay hormonal, nutritional, genetic, environmental factors. Current limitations accurate diagnostic biomarkers have rendered it a diagnosis exclusion important exclude alternative or coexisting causes PeFLD. Lifestyle changes modifications remains primary treatment modality children. Weight loss 7%–10% described reversing patients. Mediterranean diet shows promise MAFLD. Pharmacological intervention debatable children, though trials not shown promise, other agents undergoing adult clinical show promise. This review outlines latest evidence its management.

Язык: Английский

Процитировано

12
Bioelectrical impedance parameters add incremental value to waist-to-hip ratio for prediction of metabolic dysfunction associated steatotic liver disease in youth with overweight and obesity DOI Creative Commons
Kyungchul Song,

Eun Gyung Seol,

Hyejin Yang

и другие.

Frontiers in Endocrinology, Год журнала: 2024, Номер 15

Опубликована: Май 31, 2024

Introduction Metabolic dysfunction-associated steatotic liver disease (MASLD) presents a growing health concern in pediatric populations due to its association with obesity and metabolic syndrome. Bioelectrical impedance analysis (BIA) offers non-invasive potentially effective alternative for identifying MASLD risk youth overweight or obesity. Therefore, this study aimed assess the utility of BIA screening youth. Method This retrospective, cross-sectional included 206 children adolescents aged <20 years who were obese. The correlations between anthropometric measurements parameters alanine aminotransferase (ALT) levels assessed using Pearson’s correlation analysis. Logistic regression was performed examine associations these ALT level elevation score. Receiver operating characteristic (ROC) curves generated predictive ability MASLD. Results revealed that waist-to-hip ratio (WHR), percentage body fat (PBF), combined correlated level. WHR, skeletal muscle mass/WHR, PBF-WHR, fat-free appendicular mass/WHR after adjusting age, sex, puberty. visceral area (VFA)-WHR positively score total population PBF-WHR VFA-WHR even normal cutoff points under ROC 34.6 0.69 respectively, 86.6 0.79 VFA-WHR, respectively. Discussion highlights combining WHR obese youth, those BIA-based less burdensome more efficient conventional methods, facilitating early detection intervention at

Язык: Английский

Процитировано

5
Cluster analysis of diet and lifestyle factors associated with metabolic dysfunction-associated steatotic liver disease: findings from Korean Genome and Epidemiology Study DOI
Jong-Hee Lee, Ha Eun Ryu, Taehwa Han

и другие.

Endocrine, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Bioelectrical impedance analysis parameters are superior to liver enzymes in predicting metabolic dysfunction-associated steatotic liver disease in young adults DOI
Kyungchul Song, Yu‐Jin Kwon, Eun Ju Lee

и другие.

Internal and Emergency Medicine, Год журнала: 2025, Номер unknown

Опубликована: Апрель 9, 2025

Язык: Английский

Процитировано

0
Early life factors of precocious puberty based on Korean nationwide data DOI Creative Commons
Myeongseob Lee, Jung-Hyun Kim, Haedong Kim

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Май 9, 2025

Язык: Английский

Процитировано

0
The Impact of the COVID-19 Pandemic in the Interrelationships Among Mental Health, Nutritional Status and Lifestyle Factors of Older Adults: A Cross-Sectional Study in the Pre- and Post-Covid Periods DOI Open Access

Antonios Dakanalis,

Evmorfia Psara,

Eleni Pavlidou

и другие.

Nutrients, Год журнала: 2025, Номер 17(2), С. 249 - 249

Опубликована: Янв. 10, 2025

The COVID-19 pandemic has led to detrimental effects on diverse aspects of the mental and physical health general population worldwide. elderly are more susceptible infection compared younger age groups. In this aspect, purpose current survey is evaluate effect interrelationships among sociodemographic anthropometric characteristics, depressive behavior, quality life, cognition status, activity nutritional status older adults. present study constitutes a comparative, cross-sectional 4162 adults (mean ± standard deviation: 72.13 8.1 years 75.22 8.2 in pre- post-COVID-19 periods, respectively, male/female ratio almost 1:1). We used validated questionnaires assess depression, function, pre-Covid post-Covid periods. Relevant were also for collecting data, while data measured using protocols. finds that influenced, an independent manner, residence location, smoking overweight/obesity abdominal obesity, levels elderly. was related employment living as well family economic status. Nevertheless, above three relationships insignificant multivariate analysis. exerted deleterious several elderly, which appeared strongly persist period. Future prospective population-based well-organized surveys should be conducted establish whether there causality long-term

Язык: Английский

Процитировано

0
Development and validation of a machine learning model for predicting pediatric metabolic syndrome using anthropometric and bioelectrical impedance parameters DOI
Youngha Choi, Kanghyuck Lee,

Eun Gyung Seol

и другие.

International Journal of Obesity, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Identification of pediatric MASLD using insulin resistance indices DOI Creative Commons
Kyungchul Song, Eun‐Ju Lee, Hye Sun Lee

и другие.

JHEP Reports, Год журнала: 2025, Номер unknown, С. 101419 - 101419

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Prediction of insulin resistance and elevated liver transaminases using serum uric acid and derived markers in children and adolescents DOI
Youngha Choi, Hyejin Yang, Soyoung Jeon

и другие.

European Journal of Clinical Nutrition, Год журнала: 2024, Номер 78(10), С. 864 - 871

Опубликована: Июль 26, 2024

Язык: Английский

Процитировано

2
High-Sensitivity C-Reactive Protein Levels in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), Metabolic Alcohol-Associated Liver Disease (MetALD), and Alcoholic Liver Disease (ALD) with Metabolic Dysfunction DOI Creative Commons
Seong‐Uk Baek, Jin‐Ha Yoon

Biomolecules, Год журнала: 2024, Номер 14(11), С. 1468 - 1468

Опубликована: Ноя. 18, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a recently introduced term for (SLD). Although the inflammatory process central to pathogenesis of SLD, research investigating differences in systemic inflammation across various SLD subtypes as well sex limited. This population-based, cross-sectional study investigated association between and high-sensitivity C-reactive protein (hs-CRP) levels among Korean adults (N = 20,141; mean age: 50.8 ± 16.7 years). The participants were classified into five groups that included no MASLD, metabolic alcohol-associated (MetALD), alcoholic with dysfunction (ALD MD), other SLDs. median (Q1, Q3) value hs-CRP level was 0.54 mg/L (0.33, 1.04). Among men, compared group, MetALD, ALD MD associated 41.9% (95% confidence interval [CI]: 35.1-49.1%), 46.8% CI: 35.0-59.6%), 51.8% 30.0-77.2%) increases levels, respectively. stronger women, 81.5% 73.6-89.8%), 84.3% 58.1-114.8%), 98.2% 38.0-184.8%) In conclusion, our findings indicate varying profile subtypes, more pronounced women

Язык: Английский

Процитировано

2