Vitamin D Attenuates Non-Alcoholic Fatty Liver Disease in High-Fat Diet-Induced Obesity Murine Model DOI Creative Commons
Sook In Chung, Lin Liang, Heejae Han

et al.

Yonsei Medical Journal, Journal Year: 2024, Volume and Issue: 66(2), P. 75 - 75

Published: Dec. 10, 2024

Obesity and metabolic syndrome are acknowledged as key factors contributing to the development of non-alcoholic fatty liver disease (NAFLD). Vitamin D (VitD) is a multifaceted secosteroid hormone known for its anti-fibrotic anti-inflammatory properties, with deficiency often linked obesity. Our study aimed investigate whether VitD supplementation could mitigate pathology associated NAFLD. The NAFLD model was developed by subjecting male C57BL/6 mice high-fat diet (HFD) 14 weeks. These were supplemented through intraperitoneal injection at dosage 7 µg/kg, administered three times per week HFD resulted in deficiency, insulin resistance, increased weight. It elevated serum levels aminotransferases triglyceride, ultimately leading steatohepatitis fibrosis. This exhibited transforming growth factor (TGF)-β1, pro-inflammatory cytokines, HNF4α transcription factors, reactive oxygen species (ROS), renin-angiotensin system activity, epithelial-mesenchymal transitions (EMT) within liver. Supplementation recovery weight, improvement histologic features steatohepatitis, reduction alanine triglyceride induced HFD. Additionally, it mitigated HFD-induced over-expressions TGF-β1 fibrosis-related genes, along cytokines ROS. Notably, no adverse effect found due this model. ameliorates obesity-induced pathways. emerges potentially safe, cost-effective, direct treatment approach patients dealing obesity or dysfunction.

Language: Английский

Updates in Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) in Children DOI
Kushila Rupasinghe, Jonathan Hind, Robert Hegarty

et al.

Journal of Pediatric Gastroenterology and Nutrition, Journal Year: 2023, Volume and Issue: 77(5), P. 583 - 591

Published: Aug. 18, 2023

The obesity epidemic is one of the major health concerns 21st century. Nonalcoholic fatty liver disease (NAFLD) linked with increased adiposity associated obesity. NAFLD has become most frequent cause chronic in adults and children worldwide. Metabolic dysfunction-associated (MAFLD) also known as pediatric (PeFLD) type 2 begun to supersede preferred nomenclature population. Evidence suggests etiology MAFLD multifactorial, related complex interplay hormonal, nutritional, genetic, environmental factors. Current limitations accurate diagnostic biomarkers have rendered it a diagnosis exclusion important exclude alternative or coexisting causes PeFLD. Lifestyle changes modifications remains primary treatment modality children. Weight loss 7%–10% described reversing patients. Mediterranean diet shows promise MAFLD. Pharmacological intervention debatable children, though trials not shown promise, other agents undergoing adult clinical show promise. This review outlines latest evidence its management.

Language: Английский

Citations

12
Bioelectrical impedance parameters add incremental value to waist-to-hip ratio for prediction of metabolic dysfunction associated steatotic liver disease in youth with overweight and obesity DOI Creative Commons
Kyungchul Song,

Eun Gyung Seol,

Hyejin Yang

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: May 31, 2024

Introduction Metabolic dysfunction-associated steatotic liver disease (MASLD) presents a growing health concern in pediatric populations due to its association with obesity and metabolic syndrome. Bioelectrical impedance analysis (BIA) offers non-invasive potentially effective alternative for identifying MASLD risk youth overweight or obesity. Therefore, this study aimed assess the utility of BIA screening youth. Method This retrospective, cross-sectional included 206 children adolescents aged <20 years who were obese. The correlations between anthropometric measurements parameters alanine aminotransferase (ALT) levels assessed using Pearson’s correlation analysis. Logistic regression was performed examine associations these ALT level elevation score. Receiver operating characteristic (ROC) curves generated predictive ability MASLD. Results revealed that waist-to-hip ratio (WHR), percentage body fat (PBF), combined correlated level. WHR, skeletal muscle mass/WHR, PBF-WHR, fat-free appendicular mass/WHR after adjusting age, sex, puberty. visceral area (VFA)-WHR positively score total population PBF-WHR VFA-WHR even normal cutoff points under ROC 34.6 0.69 respectively, 86.6 0.79 VFA-WHR, respectively. Discussion highlights combining WHR obese youth, those BIA-based less burdensome more efficient conventional methods, facilitating early detection intervention at

Language: Английский

Citations

5
Cluster analysis of diet and lifestyle factors associated with metabolic dysfunction-associated steatotic liver disease: findings from Korean Genome and Epidemiology Study DOI
Jong-Hee Lee, Ha Eun Ryu, Taehwa Han

et al.

Endocrine, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Bioelectrical impedance analysis parameters are superior to liver enzymes in predicting metabolic dysfunction-associated steatotic liver disease in young adults DOI
Kyungchul Song, Yu‐Jin Kwon, Eun Ju Lee

et al.

Internal and Emergency Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Language: Английский

Citations

0
Early life factors of precocious puberty based on Korean nationwide data DOI Creative Commons
Myeongseob Lee, Jung-Hyun Kim, Haedong Kim

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: May 9, 2025

Language: Английский

Citations

0
The Impact of the COVID-19 Pandemic in the Interrelationships Among Mental Health, Nutritional Status and Lifestyle Factors of Older Adults: A Cross-Sectional Study in the Pre- and Post-Covid Periods DOI Open Access

Antonios Dakanalis,

Evmorfia Psara,

Eleni Pavlidou

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(2), P. 249 - 249

Published: Jan. 10, 2025

The COVID-19 pandemic has led to detrimental effects on diverse aspects of the mental and physical health general population worldwide. elderly are more susceptible infection compared younger age groups. In this aspect, purpose current survey is evaluate effect interrelationships among sociodemographic anthropometric characteristics, depressive behavior, quality life, cognition status, activity nutritional status older adults. present study constitutes a comparative, cross-sectional 4162 adults (mean ± standard deviation: 72.13 8.1 years 75.22 8.2 in pre- post-COVID-19 periods, respectively, male/female ratio almost 1:1). We used validated questionnaires assess depression, function, pre-Covid post-Covid periods. Relevant were also for collecting data, while data measured using protocols. finds that influenced, an independent manner, residence location, smoking overweight/obesity abdominal obesity, levels elderly. was related employment living as well family economic status. Nevertheless, above three relationships insignificant multivariate analysis. exerted deleterious several elderly, which appeared strongly persist period. Future prospective population-based well-organized surveys should be conducted establish whether there causality long-term

Language: Английский

Citations

0
Development and validation of a machine learning model for predicting pediatric metabolic syndrome using anthropometric and bioelectrical impedance parameters DOI
Youngha Choi, Kanghyuck Lee,

Eun Gyung Seol

et al.

International Journal of Obesity, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Identification of pediatric MASLD using insulin resistance indices DOI Creative Commons
Kyungchul Song, Eun‐Ju Lee, Hye Sun Lee

et al.

JHEP Reports, Journal Year: 2025, Volume and Issue: unknown, P. 101419 - 101419

Published: April 1, 2025

Language: Английский

Citations

0
Prediction of insulin resistance and elevated liver transaminases using serum uric acid and derived markers in children and adolescents DOI
Youngha Choi, Hyejin Yang, Soyoung Jeon

et al.

European Journal of Clinical Nutrition, Journal Year: 2024, Volume and Issue: 78(10), P. 864 - 871

Published: July 26, 2024

Language: Английский

Citations

2
High-Sensitivity C-Reactive Protein Levels in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), Metabolic Alcohol-Associated Liver Disease (MetALD), and Alcoholic Liver Disease (ALD) with Metabolic Dysfunction DOI Creative Commons
Seong‐Uk Baek, Jin‐Ha Yoon

Biomolecules, Journal Year: 2024, Volume and Issue: 14(11), P. 1468 - 1468

Published: Nov. 18, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a recently introduced term for (SLD). Although the inflammatory process central to pathogenesis of SLD, research investigating differences in systemic inflammation across various SLD subtypes as well sex limited. This population-based, cross-sectional study investigated association between and high-sensitivity C-reactive protein (hs-CRP) levels among Korean adults (N = 20,141; mean age: 50.8 ± 16.7 years). The participants were classified into five groups that included no MASLD, metabolic alcohol-associated (MetALD), alcoholic with dysfunction (ALD MD), other SLDs. median (Q1, Q3) value hs-CRP level was 0.54 mg/L (0.33, 1.04). Among men, compared group, MetALD, ALD MD associated 41.9% (95% confidence interval [CI]: 35.1-49.1%), 46.8% CI: 35.0-59.6%), 51.8% 30.0-77.2%) increases levels, respectively. stronger women, 81.5% 73.6-89.8%), 84.3% 58.1-114.8%), 98.2% 38.0-184.8%) In conclusion, our findings indicate varying profile subtypes, more pronounced women

Language: Английский

Citations

2