Cancer Control, Год журнала: 2024, Номер 31
Опубликована: Янв. 1, 2024
Liver cancer (LivCa) is a growing concern in the MENA region, driven by diverse factors, including viral hepatitis, lifestyle-related risks, and other causes.
Язык: Английский
Clinical and Molecular Hepatology, Год журнала: 2023, Номер 29(2), С. 355 - 357
Опубликована: Март 9, 2023
Язык: Английский
Процитировано
78
Hepatology International, Год журнала: 2024, Номер 18(S2), С. 922 - 940
Опубликована: Июль 16, 2024
Язык: Английский
Процитировано
13
Clinical and Molecular Hepatology, Год журнала: 2024, Номер unknown
Опубликована: Дек. 26, 2024
Hepatocellular carcinoma (HCC) is a major global burden, ranking as the third leading cause of cancer-related mortality.HCC due to chronic hepatitis B virus (HBV) or C (HCV) infection has decreased universal vaccination for HBV and effective antiviral therapy both HCV, but HCC related metabolic dysfunction associated steatotic liver disease (MASLD) alcohol-associated (ALD) increasing.Biannual ultrasonography serum α-fetoprotein are primary surveillance tools early detection among high-risk patients (e.g., cirrhosis, HBV).Alternative such blood-based biomarker panels abbreviated MRIs being investigated.Multiphasic CT MRI standard diagnosis, histological confirmation should be considered, especially when inconclusive findings seen on cross-sectional imaging.Staging treatment decisions complex made in multidisciplinary settings, incorporating multiple factors including tumor degree dysfunction, patient performance status, available expertise, preferences.Early-stage best treated with curative options resection, ablation, transplantation.For intermediatestage disease, locoregional therapies primarily recommended although systemic may preferred large intrahepatic burden.In advanced-stage immune checkpoint inhibitor (ICI)-based regimen.In this review article, we discuss recent epidemiology, risk factors, care continuum encompassing surveillance, staging, treatments.
Язык: Английский
Процитировано
11
Hepatology International, Год журнала: 2025, Номер unknown
Опубликована: Янв. 11, 2025
Liver cancer (LC) is a major concern in the Asia-Pacific region, particularly China, Korea, and Japan. In this study, we aimed to investigate burden, trends, predictions related LC these countries. Using data from Global Burden of Disease Study 2021, epidemiological characteristics [incidence, deaths, disability-adjusted life-years (DALYs)] for were analysed stratified by specific etiologies Japan, South Korea. We examined temporal trends burden over last 32 years projected changes following 25 years. The risk factors associated with deaths DALYs also investigated. highest LC-related incidence, mortality, recorded China (196,637 incidents, 172,068 mortalities, 4,890,023 DALYs), lowest Korea (18,642 13,674 326,336 DALYs). age-standardized rates (ASRs) (19.94 per 100,000, 14.53 354.57 100,000), Japan (9.89, 7.29, 145.74, respectively). From 1990 incidents three countries increased, ASRs decreased. caused five increased past years, non-alcoholic steatohepatitis (NASH) was largest increasing China. Infections hepatitis B virus remained leading cause while C prevailing High body mass index (BMI) most sharply factor Alcohol drug use main respectively. rise steadily between 2022 2046. remains significant disease now next Regarding factors, NASH high BMI alcohol should receive attention.
Язык: Английский
Процитировано
2
Journal of Gastroenterology, Год журнала: 2023, Номер 58(12), С. 1222 - 1236
Опубликована: Сен. 4, 2023
Язык: Английский
Процитировано
19
BMC Public Health, Год журнала: 2025, Номер 25(1)
Опубликована: Янв. 6, 2025
Gastrointestinal (GI) cancers account for over a quarter of all cancer-related deaths in the United States; however, latest trends their prevalence remain unclear. Data on GI were obtained from Global Burden Disease Study 2021. Age-standardized incidence rates (ASIR) and age-standardized mortality (ASMR) estimated across various states, sexes, ages, risk factors, annual percentage changes calculated. From 2000 to 2021, liver cancer exhibited greatest increase both ASIR ASMR, followed by pancreatic cancer. In contrast, stomach showed decline, colorectal cancer, esophageal biliary tract Most predominantly affect men tend toward younger age onset. Geographic disparities exist burden factors. For esophageal, stomach, cancers, linked diet smoking decreased, whereas alcohol-related increased several especially West Virginia. Hepatitis C remains leading cause with intravenous drug use as primary factor. Non-alcoholic steatohepatitis (NASH) is fastest-growing excessive alcohol use. Mortality due high body-mass index fasting plasma glucose have states groups. The epidemiological U.S. shifted substantially. States need implement targeted policies that address specific populations factors each type.
Язык: Английский
Процитировано
1
Drug Metabolism and Personalized Therapy, Год журнала: 2025, Номер unknown
Опубликована: Апрель 22, 2025
Abstract Objectives Hepatocellular carcinoma (HCC) is a common type of liver cancer that progresses quickly and has limited treatment options. Nutraceutical anacardic acid (AA), bioactive compound derived from cashew nut shell, emerged as potential candidate for HCC owing to its reported anti-inflammatory, anticancer diverse pharmacological properties. In the present study, we investigate AA an inhibitor using molecular docking, gene ontology, network pharmacology. Methods The pharmacokinetic physicochemical properties were assessed Swiss ADME. SuperPred, Similarity Ensemble Approach, ChEMBL Target Prediction online tools used determining targets AA. addition, GeneCards, NCBI, DisGeNET UniProt ID search top 25 hub genes determined Cytohubba plugin. A protein interaction (PPI) was constructed through STRING database. Gene Ontology (GO) biological process Kyoto Encyclopaedia Genes (KEGG) pathway enrichment analysis performed FunRich ShinyGO 0.77. Moreover, docking studies on NF-κB GSK-3β. expression levels also validated by western blotting. Results Comprehensive data identified 375 11,333 HCC, with 264 in common. Network key targets, including caspase-3, NF-κB. ontology topology highlighted essential pathways implicated progression such renin-angiotensin system, VEGF signalling, apoptosis. Molecular revealed strong binding affinity proteins Upregulation p-NRF2 p-GSK-3β, downregulation p-NF-κB caspase-1 Conclusions Taken together, our study highlights promising chemopreventive agent because significant modulatory effects important regulatory linked cell division, inflammation, apoptosis, antioxidant response.
Язык: Английский
Процитировано
1
Applied Mathematical Modelling, Год журнала: 2024, Номер 134, С. 148 - 174
Опубликована: Июнь 10, 2024
Язык: Английский
Процитировано
6
Chinese Medical Journal, Год журнала: 2024, Номер 137(19), С. 2334 - 2342
Опубликована: Сен. 3, 2024
Abstract Background: Liver cancer remains the sixth most commonly diagnosed and third leading cause of cancer-related deaths worldwide, causing a heavy burden globally. An updated assessment global epidemiology liver that addresses geographical disparities is necessary to better understand promote healthcare delivery. Methods: Data were extracted from GLOBOCAN 2022 database, including number, crude, age-standardized rates incidence mortality at global, country, continent, human development index (HDI) regional levels. Age-standardized (incidence mortality) per 100,000 person-years adjusted based on Segi-Doll World standard population. The mortality-to-incidence ratios (MIR) for each region country calculated. HDI gross national income (GNI) obtained, Pearson correlation analysis was conducted with incidence, mortality, MIR. Results: In 2022, approximately 866,136 new cases 758,725 related recorded MIR 0.86. Males had disproportionately higher than females across all levels, highest observed in elderly Geographically, regions included Micronesia, Eastern Asia, Northern Africa, Southeastern Micronesia. Notably, Mongolia strikingly high compared other countries. North America lowest Africa. Negative associations GNI identified, irrespective sex. Conclusions: current underscores presence remarkable geographic heterogeneity, which particularly evident countries varying highlighting urgent need prioritize health accessibility availability achieve inequities.
Язык: Английский
Процитировано
6
Gastroenterology report, Год журнала: 2023, Номер 12
Опубликована: Дек. 22, 2023
Abstract Chronic liver disease presents a significant global health burden, characterized by several etiologies, including metabolic dysfunction-associated steatotic (MASLD), alcohol-related (ALD), chronic hepatitis B virus infection, and C infection. This review explored current epidemiological trends projections for each etiology, looking into their respective burdens challenges. MASLD, formerly known as nonalcoholic fatty disease, is the most prevalent cause of its incidence prevalence are steadily rising. ALD, fueled increased alcohol consumption, also on rise, with concerning implications future mortality rates. infections remain major public concerns, particularly in specific regions world, necessitating concerted efforts screening treatment. The coronavirus 2019 (COVID-19) pandemic has impacted epidemiology exacerbating rates disrupting healthcare services. Mental issues arising from further complicate treatment making comprehensive strategies essential. Despite advancements treatment, continues to impose substantial economic emphasizing importance preventive measures early intervention. In conclusion, ongoing surveillance research crucial understanding addressing evolving landscape disease. Comprehensive that encompass prevention, screening, different etiologies essential mitigating impact improving patient outcomes.
Язык: Английский
Процитировано
13