Non-alcoholic fatty liver disease: Immunological mechanisms and current treatments DOI Creative Commons
Lucy Petagine, Mohammed Gulrez Zariwala, Vinood B. Patel

и другие.

World Journal of Gastroenterology, Год журнала: 2023, Номер 29(32), С. 4831 - 4850

Опубликована: Авг. 24, 2023

Non-alcoholic fatty liver disease (NAFLD) causes significant global burden and is a leading cause of mortality. NAFLD induces myriad aberrant changes in hepatocytes at both the cellular molecular level. Although spectrum widely recognised, precise triggers for progression are still to be fully elucidated. Furthermore, propagation cirrhosis poorly understood. Whilst some progress terms treatment options have been explored, an incomplete understanding hepatic alterations limits their clinical utility. We therefore reviewed key pathways responsible pathogenesis such as innate adaptative immunity, lipotoxicity fibrogenesis, highlighted current trials patients.

Язык: Английский

Noninvasive Assessment of Liver Fibrosis in NAFLD DOI Creative Commons
Arun J. Sanyal, Laurent Castéra, Vincent Wai‐Sun Wong

и другие.

Clinical Gastroenterology and Hepatology, Год журнала: 2023, Номер 21(8), С. 2026 - 2039

Опубликована: Апрель 14, 2023

Язык: Английский

Процитировано

75

Non-invasive Scores and Serum Biomarkers for Fatty Liver in the Era of Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD): A Comprehensive Review From NAFLD to MAFLD and MASLD DOI Creative Commons
Farah Abdelhameed, Chris Kite, Lukasz Lagojda

и другие.

Current Obesity Reports, Год журнала: 2024, Номер 13(3), С. 510 - 531

Опубликована: Май 29, 2024

The prevalence of non-alcoholic fatty liver disease (NAFLD) is rapidly increasing worldwide, making it the leading cause related morbidity and mortality. Currently, biopsy gold standard for assessing individuals with steatohepatitis fibrosis. However, its invasiveness, sampling variability, impracticality large-scale screening has driven search non-invasive methods early diagnosis staging. In this review, we comprehensively summarise evidence on diagnostic performance limitations existing serum biomarkers scores in evaluation steatosis, steatohepatitis,

Язык: Английский

Процитировано

45

WFUMB Guideline/Guidance on Liver Multiparametric Ultrasound: Part 1. Update to 2018 Guidelines on Liver Ultrasound Elastography DOI Creative Commons
Giovanna Ferraioli, R. Graham Barr, Annalisa Berzigotti

и другие.

Ultrasound in Medicine & Biology, Год журнала: 2024, Номер 50(8), С. 1071 - 1087

Опубликована: Май 17, 2024

Язык: Английский

Процитировано

40

Steatotic liver disease predicts cardiovascular disease and advanced liver fibrosis: A community-dwelling cohort study with 20-year follow-up DOI
Hun Jee Choe, Joon Ho Moon, Won Kim

и другие.

Metabolism, Год журнала: 2024, Номер unknown, С. 155800 - 155800

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

30

NAFLD/MASLD and the Gut–Liver Axis: From Pathogenesis to Treatment Options DOI Creative Commons
Natalia G. Vallianou, Dimitris Kounatidis,

Sotiria Psallida

и другие.

Metabolites, Год журнала: 2024, Номер 14(7), С. 366 - 366

Опубликована: Июнь 28, 2024

Nonalcoholic fatty liver disease (NAFLD) poses an emerging threat topublic health. steatohepatitis (NASH) is reported to be the most rapidly rising cause of hepatocellular carcinoma in western world. Recently, a new term has been proposed: metabolic dysfunction-associated steatotic (MASLD). The introduction this terminology sparked debate about interchangeability these terms. pathogenesis NAFLD/MASLD thought multifactorial, involving both genetic and environmental factors. Among factors, alterations gut microbiota dysbiosis have recently garnered significant attention. In context, review will further discuss gut-liver axis, which refers bidirectional interaction between human liver. Additionally, therapeutic potential probiotics, particularly next-generation probiotics genetically engineered bacteria, explored. Moreover, role prebiotics, synbiotics, postbiotics, phages as well fecal transplantation analyzed. Particularly for lean patients with NAFLD/MASLD, who limited treatment options, approaches that modify diversity composition may hold promise. However, due ongoing safety concerns modulate microbiota, large-scale studies are necessary better assess their efficacy treating NAFLD/MASLD.

Язык: Английский

Процитировано

25

Does Resveratrol Improve Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)? DOI Open Access
Kamila Kasprzak‐Drozd, Przemysław Niziński,

Paulina Kasprzak

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(7), С. 3746 - 3746

Опубликована: Март 27, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) is influenced by a variety of factors, including environmental and genetic factors. The most significant outcome the alteration free fatty acid triglyceride metabolism. Lipotoxicity, impaired autophagy, chronic inflammation, oxidative stress, as well coexisting insulin resistance, obesity, changes in composition gut microbiota, are also considered crucial factors pathogenesis MASLD. Resveratrol polyphenolic compound that belongs to stilbene subgroup. This review summarises available information on therapeutic effects resveratrol against has demonstrated promising antisteatotic, antioxidant, anti-inflammatory activities cells vitro animal studies. been associated with inhibiting NF-κB pathway, activating SIRT-1 AMPK pathways, normalizing intestinal microbiome, alleviating inflammation. However, clinical studies have yielded inconclusive results regarding efficacy hepatic steatosis or reducing any parameters found MASLD human patients. lack homogeneity between studies, low bioavailability resveratrol, population variability when compared models could be reasons for this.

Язык: Английский

Процитировано

20

Management of Metabolic-Associated Fatty Liver Disease/Metabolic Dysfunction-Associated Steatotic Liver Disease: From Medication Therapy to Nutritional Interventions DOI Open Access
M H Miran Beygi, Salma Ahi, Samaneh Zolghadri

и другие.

Nutrients, Год журнала: 2024, Номер 16(14), С. 2220 - 2220

Опубликована: Июль 11, 2024

Non-alcoholic fatty liver disease (NAFLD) is a common long-lasting that affects millions of people around the world. It best identified with hepatic fat build-up ultimately leads to inflammation and damage. The classification nomenclature NAFLD have long been controversial topic, until 2020 when group international experts recommended substituting MAFLD (metabolic dysfunction-associated FLD). was then terminologically complemented in 2023 by altering it MASLD, i.e., metabolic steatotic (MASLD). Both MASLD terminologies comprise element disorder, as they offer diagnostic benchmarks are embedded risk factors underlie disease. (as multisystemic disease) provides comprehensive definition includes larger population patients who at morbidity mortality, well adverse cardiovascular diabetes outcomes. highlights risks lean or normal weight individuals, factor has not accentuated discussed previous guidelines. Novel antihyperglycemic agents, anti-hyperlipidemic drugs, lifestyle modifications, nutritional interventions, exercise therapies extensively studied MASLD. Nutrition plays vital role managing both conditions, where centralizing on diet rich whole vegetables, fruits, foods, healthy fats, proteins, specific nutrients (e.g., omega-3 acids fibers) can improve insulin resistance reduce inflammation. Thus, essential understand nutrition these conditions work develop an individualized plan for optimal health. This review discusses prevention strategies NAFLD/MAFLD/MASLD management, particular attention correction.

Язык: Английский

Процитировано

20

Liver diseases: epidemiology, causes, trends and predictions DOI Creative Commons

Can Gan,

Yuan Yuan, Haiyuan Shen

и другие.

Signal Transduction and Targeted Therapy, Год журнала: 2025, Номер 10(1)

Опубликована: Фев. 4, 2025

Abstract As a highly complex organ with digestive, endocrine, and immune-regulatory functions, the liver is pivotal in maintaining physiological homeostasis through its roles metabolism, detoxification, immune response. Various factors including viruses, alcohol, metabolites, toxins, other pathogenic agents can compromise function, leading to acute or chronic injury that may progress end-stage diseases. While sharing common features, diseases exhibit distinct pathophysiological, clinical, therapeutic profiles. Currently, contribute approximately 2 million deaths globally each year, imposing significant economic social burdens worldwide. However, there no cure for many kinds of diseases, partly due lack thorough understanding development these Therefore, this review provides comprehensive examination epidemiology characteristics covering spectrum from conditions manifestations. We also highlight multifaceted mechanisms underlying initiation progression spanning molecular cellular levels networks. Additionally, offers updates on innovative diagnostic techniques, current treatments, potential targets presently under clinical evaluation. Recent advances pathogenesis hold critical implications translational value novel strategies.

Язык: Английский

Процитировано

6

Association between triglyceride-glucose (TyG) related indices and cardiovascular diseases and mortality among individuals with metabolic dysfunction-associated steatotic liver disease: a cohort study of UK Biobank DOI Creative Commons
Yanan Qiao, Yue Wang, Chen Cheng

и другие.

Cardiovascular Diabetology, Год журнала: 2025, Номер 24(1)

Опубликована: Янв. 13, 2025

Triglyceride-glucose (TyG) related indices, which serve as simple markers for insulin resistance, have been closely linked to metabolic dysfunction-associated steatotic liver disease (MASLD), cardiovascular (CVD), and mortality. However, the prognostic utility of TyG-related indices in predicting risk CVD mortality among patients with MASLD remains unclear. Data 97,331 patients, a median age 58.0 years free at baseline, were obtained from UK Biobank. The TyG index, along its combination adiposity parameters (i.e. body mass index [BMI], waist circumference [WC], waist-to-height ratio [WHtR]), calculated. Cox proportional hazards models restricted cubic spline (RCS) performed evaluate associations between overall CVD, coronary heart (CHD), stroke, all-cause mortality, Additionally, Harrell's C-index, net reclassification (NRI), integrated discrimination improvement (IDI) used assess predictive performance these indices. Over follow-up 13.56 years, we identified 13,256 cases 10,980 CHD, 2,926 8,809 1,796 Compared lowest quartile participants high had significantly increased incident Specifically, hazard ratios occurring fourth versus first quartiles 1.19 (95% confidence interval: 1.13-1.25) TyG, 1.35 (1.28-1.42) TyG-BMI, 1.33 (1.26-1.40) TyG-WC, 1.39 (1.32-1.46) TyG-WHtR. RCS analyses indicated nonlinear association outcomes (all P values nonlinearity < 0.05), whereas there exhibited linear trends TyG-WHtR > 0.05, except TyG-WC stroke). Furthermore, demonstrated higher NRI, IDI patients. especially TyG-WHtR, significant individuals MASLD. may effective surrogate predictors

Язык: Английский

Процитировано

4

Clinical Insights into Non-Alcoholic Fatty Liver Disease and the Therapeutic Potential of Flavonoids: An Update DOI Open Access
Aleksandra Kozłowska

Nutrients, Год журнала: 2025, Номер 17(6), С. 956 - 956

Опубликована: Март 9, 2025

Non-alcoholic fatty liver disease (NAFLD) is considered a significant global health issue related to serious metabolic disorders. However, effective pharmacological treatments are still limited. Flavonoids, wide group of polyphenol substances, exert anti-inflammatory and lipid-lowering effects in preclinical data. Thus, implementing these research findings clinical practice could significantly help manage NAFLD its consequences. This narrative review assesses the therapeutic potential flavonoids managing NAFLD. The collected randomized controlled trials (RCTs) meta-analyses RCTs from past five years concerning impact on A total 20 studies were selected according predetermined inclusion criteria, comprising thirteen seven meta-analyses. underscores beneficial management through enhancement lipid metabolism, reduction hepatic steatosis, provision actions. Clinical demonstrate that interventions rich flavonoids, including quercetin, epigallocatechin gallate, naringenin, isoflavones, substantially reduce fat content enhance enzyme profiles, with certain compounds exhibiting superior efficacy particular subgroups, such as older adults females. Nonetheless, whereas therapies diminish their effect fibrosis constrained. To sum up, exhibit supplementary for by enhancing function, inflammation. Additional extensive necessary create uniform treatment methods ascertain long-term advantages.

Язык: Английский

Процитировано

3