Metabolites,
Год журнала:
2025,
Номер
15(2), С. 127 - 127
Опубликована: Фев. 13, 2025
Numerous
recent
studies
have
suggested
that
the
composition
of
intestinal
microbiota
can
trigger
metabolic
disorders,
such
as
diabetes,
prediabetes,
obesity,
syndrome,
sarcopenia,
dyslipidemia,
hyperhomocysteinemia,
and
non-alcoholic
fatty
liver
disease.
Since
then,
considerable
effort
has
been
made
to
understand
link
between
well
role
probiotics
in
modulation
microbiota.
The
aim
this
review
was
summarize
reviews
individual
articles
on
state
art
regarding
ideal
therapy
with
prebiotics
order
obtain
reversion
dysbiosis
(alteration
microbiota)
eubiosis
during
diseases,
diseases.
This
includes
245
eligible
studies.
In
conclusion,
a
condition
dysbiosis,
or
general,
alteration
microbiota,
could
be
implicated
development
disorders
through
different
mechanisms,
mainly
linked
release
pro-inflammatory
factors.
Several
already
demonstrated
potential
using
treatment
condition,
detecting
significant
improvements
specific
symptoms
These
findings
reinforce
hypothesis
lead
generalized
inflammatory
picture
negative
consequences
organs
systems.
Moreover,
confirms
beneficial
effects
diseases
are
promising,
but
more
research
is
needed
determine
optimal
probiotic
strains,
doses,
administration
forms
for
conditions.
Clinical and Molecular Hepatology,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 26, 2024
Hepatocellular
carcinoma
(HCC)
is
a
major
global
burden,
ranking
as
the
third
leading
cause
of
cancer-related
mortality.HCC
due
to
chronic
hepatitis
B
virus
(HBV)
or
C
(HCV)
infection
has
decreased
universal
vaccination
for
HBV
and
effective
antiviral
therapy
both
HCV,
but
HCC
related
metabolic
dysfunction
associated
steatotic
liver
disease
(MASLD)
alcohol-associated
(ALD)
increasing.Biannual
ultrasonography
serum
α-fetoprotein
are
primary
surveillance
tools
early
detection
among
high-risk
patients
(e.g.,
cirrhosis,
HBV).Alternative
such
blood-based
biomarker
panels
abbreviated
MRIs
being
investigated.Multiphasic
CT
MRI
standard
diagnosis,
histological
confirmation
should
be
considered,
especially
when
inconclusive
findings
seen
on
cross-sectional
imaging.Staging
treatment
decisions
complex
made
in
multidisciplinary
settings,
incorporating
multiple
factors
including
tumor
degree
dysfunction,
patient
performance
status,
available
expertise,
preferences.Early-stage
best
treated
with
curative
options
resection,
ablation,
transplantation.For
intermediatestage
disease,
locoregional
therapies
primarily
recommended
although
systemic
may
preferred
large
intrahepatic
burden.In
advanced-stage
immune
checkpoint
inhibitor
(ICI)-based
regimen.In
this
review
article,
we
discuss
recent
epidemiology,
risk
factors,
care
continuum
encompassing
surveillance,
staging,
treatments.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Март 13, 2025
Metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD)
is
an
emerging
global
health
concern
with
limited
therapeutic
options.
Multivitamins,
widely
consumed
dietary
supplements,
have
been
proposed
to
modulate
oxidative
stress
and
inflammation,
potentially
impacting
MASLD
progression.
However,
their
efficacy
in
reducing
mortality
other
complications
remains
unclear.
Using
data
from
the
UK
Biobank
7
years
of
median
follow-up
period,
this
study
assessed
association
between
multivitamin
use
outcomes,
including
all-cause
mortality,
liver-related
cardio-cerebrovascular
(CVD),
chronic
kidney
(CKD),
individuals
those
without
disease.
Inverse
probability
treatment
weighting
(IPTW)
was
employed
adjust
for
confounders.
Multivitamin
users
showed
a
significantly
lower
risk
cohort
both
before
(HR:
0.88,
95%
CI
0.81–0.95,
P
=
0.034)
after
0.94,
0.88–1.00,
0.037)
IPTW
adjustment.
also
associated
CVD
0.72,
0.68–0.76,
<
0.001)
CKD
0.73,
0.67–0.81,
cohort.
No
significant
reduction
found
or
cirrhosis
incidence.
These
findings
suggest
that
multivitamins
might
provide
broader
protective
effects
populations
metabolic
dysfunction.
Further
research
needed
clarify
role
liver-specific
outcomes.
BMC Medical Imaging,
Год журнала:
2025,
Номер
25(1)
Опубликована: Янв. 20, 2025
The
purpose
of
our
study
was
to
investigate
the
association
between
non-alcoholic
fatty
liver
disease
(NAFLD)
and
abdominal
aortic
aneurysms
(AAA)
progression
using
non-enhanced
computed
tomography
(CT)
CT
angiography
(CTA).
Patients
with
AAA
age-
sex-matched
healthy
subjects
who
underwent
CTA
examination
January
2015
2023
from
four
hospitals
were
retrospectively
analyzed.
divided
into
(growth
rate
>
10
mL/year)
non-progression
groups,
as
well
those
NAFLD
without
NAFLD,
based
on
results.
Kaplan-Meier
Cox
regression
used
progression.
A
total
151
patients
(mean
age:
69.1
±
10.5
years
old,
133
men)
included,
among
which
66
(43.7%)
had
NAFLD.
During
a
median
10.7
months
(6.0–76.0
months),
57
(37.7%)
prevalence
significantly
higher
in
group
compared
control
(43.7%
vs.
31.1%,
p
=
0.024).
Multivariable
analysis
revealed
that
independently
associated
(HR,
4.28;
95%
CI,
2.20–8.31;
<
0.001).
area
under
curve
combined
maximal
diameter
0.857
for
predicting
is
an
independent
predictor
It
can
improve
diagnostic
efficacy
aneurysms.
Not
applicable.
This
research
retrospective
analysis.
Journal of Digestive Diseases,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 2, 2025
ABSTRACT
Objectives
Sarcopenia
increases
the
risk
of
nonalcoholic
steatohepatitis
(NASH)
and
cirrhosis
in
patients
with
fatty
liver
disease
(NAFLD).
Subsequently,
poorly
managed
NAFLD
can
result
adverse
health
outcomes.
Lifestyle
interventions
are
effective
for
both
sarcopenia;
however,
diagnosis
sarcopenia
this
population
is
not
well
defined.
This
review
aimed
to
examine
current
methods
diagnose
patients.
Methods
MEDLINE,
EMBASE,
CINAHL
databases
were
searched
articles
published
until
July
2023
using
terms
“Non‐alcoholic
disease,”
“NAFLD,”
“fatty
liver,”
“sarcopenia,”
“myoatrophy.”
Studies
excluded
if
they
included
pediatric
populations,
did
NAFLD,
or
alternate
causes
disease.
Results
Twenty
studies,
predominantly
from
Asian
countries
(14
[70.0%]),
involving
68
848
participants
(45.5%
females)
included.
In
15
most
had
a
BMI
>
25
kg/m
2
.
Heterogeneity
tools
used
was
identified,
abdominal
ultrasound
being
commonly
used.
European,
Asian,
Australasian
Working
Groups
differing
diagnostic
definitions
sarcopenia.
Of
three
potential
elements
(muscle
mass,
strength,
function),
all
studies
measured
muscle
through
bioelectrical
impedance
analysis
(12
[60.0%]).
Seven
(35.0%)
majority
(
n
=
6)
utilizing
hand
grip
strength.
Four
(20.0%)
function,
gait
speed
timed
up‐and‐go
test.
Conclusions
The
lack
standardization
concerning.
A
consistent
definition
necessary
prevent
comorbidity
overlooked,
improve
care,
Metabolites,
Год журнала:
2025,
Номер
15(2), С. 127 - 127
Опубликована: Фев. 13, 2025
Numerous
recent
studies
have
suggested
that
the
composition
of
intestinal
microbiota
can
trigger
metabolic
disorders,
such
as
diabetes,
prediabetes,
obesity,
syndrome,
sarcopenia,
dyslipidemia,
hyperhomocysteinemia,
and
non-alcoholic
fatty
liver
disease.
Since
then,
considerable
effort
has
been
made
to
understand
link
between
well
role
probiotics
in
modulation
microbiota.
The
aim
this
review
was
summarize
reviews
individual
articles
on
state
art
regarding
ideal
therapy
with
prebiotics
order
obtain
reversion
dysbiosis
(alteration
microbiota)
eubiosis
during
diseases,
diseases.
This
includes
245
eligible
studies.
In
conclusion,
a
condition
dysbiosis,
or
general,
alteration
microbiota,
could
be
implicated
development
disorders
through
different
mechanisms,
mainly
linked
release
pro-inflammatory
factors.
Several
already
demonstrated
potential
using
treatment
condition,
detecting
significant
improvements
specific
symptoms
These
findings
reinforce
hypothesis
lead
generalized
inflammatory
picture
negative
consequences
organs
systems.
Moreover,
confirms
beneficial
effects
diseases
are
promising,
but
more
research
is
needed
determine
optimal
probiotic
strains,
doses,
administration
forms
for
conditions.
