Aquaculture,
Год журнала:
2024,
Номер
587, С. 740803 - 740803
Опубликована: Март 16, 2024
The
unique
metabolic
capabilities
and
fast
growth
rates
of
microalgae
render
them
promising
candidates
for
various
industrial
applications,
such
as
biofuel
production,
pharmaceuticals,
nutraceuticals,
wastewater
treatment.
Metabolic
engineering
is
a
powerful
approach
used
to
enhance
the
sustainable
production
high-value
compounds
in
microalgae,
improve
their
stress
tolerance,
characteristics
suitability
large-scale
cultivation.
This
review
provides
snapshot
current
state
knowledge
on
omics
research
further
our
understanding
microalgal
metabolism
enable
development
optimized
strains
with
improved
productivity
functionality.
More
specifically,
it
focuses
recent
breakthroughs
omics,
driven
by
advancements
genomics
technologies,
sequencing
platforms
bioinformatics
tools,
that
have
enabled
functional
characterization
key
genes,
identification
pathways,
elucidation
cell
physiology.
Conventional
state-of-the-art
genetic
approaches
last
decades
manipulate
pathways
targeted
manner,
are
highlighted
scope
optimization.
In
this
review,
different
applications
impact
industry
also
discussed.
Integrating
pan-omics
data
future
crucial
predicting
novel
interactions
identifying
aspects
flux,
towards
enhancing
algal
strain-engineering
techniques.
Progress in Energy and Combustion Science,
Год журнала:
2023,
Номер
96, С. 101071 - 101071
Опубликована: Фев. 27, 2023
Microalgae
have
gained
considerable
attention
as
an
alternative
feedstock
for
the
biofuel
production,
particularly
in
combination
with
genetic
modification
strategies
that
target
enhanced
lipid
productivity.
To
tackle
climate
change
issues,
phasing
out
usage
of
fossil
fuels
is
seen
a
priority,
where
utilization
from
microalgae
serves
potential
sustainable
energy
source
various
applications.
These
photosynthetic
utilize
solar
and
carbon
dioxide
to
produce
energy-rich
compounds
(i.e.,
starch
lipids),
can
be
further
converted
into
biofuels
different
types.
Among
types
biofuels,
biodiesel
transesterification
triacylglycerols
stands
most
replacement
transportation
fuel
over
fossil-based
petroleum
diesel.
However,
hurdles
such
limited
productivity,
overall
production
cost
challenges
upscaling
algal
technology
leaves
huge
gap
on
road
commercialized
microalgae-based
biofuel.
This
review
article
first
presents
comprehensive
overview
imperative
knowledge
regarding
terms
classification,
factors
affecting
growth
during
cultivation
steps
upstream
processing.
also
discusses
recent
advances
downstream
processing
microalgal
biorefinery.
Additionally,
this
paper
focuses
deliberating
modifications
their
feasibility
productivity
microalgae.
Finally,
current
future
perspectives
are
highlighted
discussing
several
aspects,
including
sustainability
status
algae-based
industry,
risks
legislation
considerations
Frontiers in Nutrition,
Год журнала:
2023,
Номер
9
Опубликована: Янв. 19, 2023
Current
agricultural
and
food
production
practices
are
facing
extreme
stress,
posed
by
climate
change
an
ever-increasing
human
population.
The
pressure
to
feed
nearly
8
billion
people
while
maintaining
a
minimal
impact
on
the
environment
has
prompted
movement
toward
new,
more
sustainable
sources.
For
thousands
of
years,
both
macro
(seaweed
kelp)
micro
(unicellular)
forms
algae
have
been
cultivated
as
source.
Algae
evolved
be
highly
efficient
at
resource
utilization
proven
viable
source
nutritious
biomass
that
could
address
many
current
issues.
Particularly
for
microalgae,
studies
their
large-scale
growth
cultivation
come
from
biofuel
industry;
however,
this
knowledge
can
reasonably
translated
into
algae-based
products.
ability
sequester
CO
2
lends
its
sustainability
helping
reduce
carbon
footprint
production.
Additionally,
produced
non-arable
land
using
non-potable
water
(including
brackish
or
seawater),
which
allows
them
complement
rather
than
compete
with
traditional
agriculture.
inherently
desired
qualities
because
they
produce
digestible
proteins,
lipids,
carbohydrates,
rich
in
essential
fatty
acids,
vitamins,
minerals.
Although
yet
fully
domesticated
sources,
variety
breeding
tools
exist
built
upon
allow
increased
productivity
enhanced
nutritional
organoleptic
will
required
bring
mainstream
utilization.
Here
we
focus
microalgae
cyanobacteria
highlight
advancements
expand
well
outline
various
challenges
between
economic
market.
Marine Drugs,
Год журнала:
2022,
Номер
20(7), С. 440 - 440
Опубликована: Июнь 30, 2022
Microalgae
have
become
a
promising
novel
and
sustainable
feedstock
for
meeting
the
rising
demand
food
feed.
However,
microalgae-based
products
are
currently
hindered
by
high
production
costs.
One
major
reason
this
is
that
commonly
cultivated
wildtype
strains
do
not
possess
robustness
productivity
required
successful
industrial
production.
Several
strain
improvement
technologies
been
developed
towards
creating
more
stress
tolerant
productive
strains.
While
classical
methods
of
forward
genetics
extensively
used
to
determine
gene
function
randomly
generated
mutants,
reverse
has
explored
generate
specific
mutations
target
phenotypes.
Site-directed
mutagenesis
can
be
accomplished
employing
different
editing
tools,
which
enable
generation
tailor-made
genotypes.
Nevertheless,
strategies
promoting
selection
mutants
avoid
introduction
foreign
genetic
material.
In
paper,
we
review
microalgal
approaches
their
applications,
with
primary
focus
on
random
mutagenesis.
Current
challenges
hampering
improvement,
selection,
commercialization
will
discussed.
The
combination
these
high-throughput
technologies,
such
as
fluorescence-activated
cell
sorting,
tools
select
most
also
Biotechnology for Biofuels and Bioproducts,
Год журнала:
2024,
Номер
17(1)
Опубликована: Янв. 23, 2024
Abstract
The
development
of
microalgal
biofuels
is
significant
importance
in
advancing
the
energy
transition,
alleviating
food
pressure,
preserving
natural
environment,
and
addressing
climate
change.
Numerous
countries
regions
across
globe
have
conducted
extensive
research
strategic
planning
on
bioenergy,
investing
funds
manpower
into
this
field.
However,
microalgae
biofuel
industry
has
faced
a
downturn
due
to
constraints
high
costs.
In
past
decade,
with
new
strains,
technologies,
equipment,
feasibility
large-scale
production
should
be
re-evaluated.
Here,
we
gathered
results
from
decade
regarding
production,
providing
insights
opportunities
challenges
by
perspectives
selection,
modification,
cultivation.
review,
suggest
that
highly
adaptable
are
preferred
choice
for
especially
strains
can
utilize
concentrations
inorganic
carbon
sources
possess
stress
resistance.
use
omics
technologies
genetic
editing
greatly
enhanced
lipid
accumulation
microalgae.
associated
risks
constrained
outdoor
Therefore,
relatively
controllable
cultivation
method
photobioreactors
(PBRs)
made
it
mainstream
approach
production.
Moreover,
adjusting
performance
parameters
PBRs
also
enhance
future,
given
relentless
escalation
demand
sustainable
sources,
deemed
pivotal
constituent
national
planning,
particularly
case
China.
advancement
synthetic
biology
helps
reduce
genetically
modified
(GM)
enhances
economic
viability
their
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