Frontiers in Bioengineering and Biotechnology,
Год журнала:
2025,
Номер
12
Опубликована: Янв. 22, 2025
Cerebrovascular
imaging
is
essential
for
the
diagnosis,
treatment,
and
prognosis
of
cerebrovascular
disease,
including
stroke,
aneurysms,
vascular
malformations.
Conventional
techniques
such
as
MRI,
CT,
DSA
ultrasound
have
their
own
strengths
limitations,
particularly
in
terms
resolution,
contrast
safety.
Recent
advances
nanotechnology
offer
new
opportunities
improved
imaging.
Nanomaterials,
metallic
nanoparticles,
magnetic
quantum
dots,
carbon-based
nanomaterials,
polymer
show
great
potential
due
to
unique
physical,
chemical,
biological
properties.
This
review
summarizes
recent
advanced
nanomaterials
applications
various
techniques,
discusses
challenges
future
research
directions.
The
aim
provide
valuable
insights
researchers
facilitate
development
clinical
application
these
innovative
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(4), С. 2360 - 2360
Опубликована: Фев. 17, 2024
This
review
explores
the
diverse
applications
of
gold
nanoparticles
(AuNPs)
in
neurological
diseases,
with
a
specific
focus
on
Alzheimer's
disease
(AD),
Parkinson's
(PD),
and
stroke.
The
introduction
highlights
pivotal
role
neuroinflammation
these
disorders
introduces
unique
properties
AuNPs.
review's
core
examines
mechanisms
by
which
AuNPs
exert
neuroprotection
anti-neuro-inflammatory
effects,
elucidating
various
pathways
through
they
manifest
properties.
potential
therapeutic
AD
are
discussed,
shedding
light
promising
avenues
for
therapy.
also
prospects
utilizing
PD
interventions,
presenting
hopeful
outlook
future
treatments.
Additionally,
delves
into
providing
after
strokes,
emphasizing
their
significance
mitigating
cerebrovascular
accidents'
aftermath.
Experimental
findings
from
cellular
animal
models
consolidated
to
provide
comprehensive
overview
AuNPs'
effectiveness,
offering
insights
impact
at
both
vivo
levels.
enhances
our
understanding
diseases
lays
groundwork
innovative
strategies
neurology.
Frontiers in Nanotechnology,
Год журнала:
2024,
Номер
6
Опубликована: Окт. 11, 2024
Nanoparticulate
delivery
systems
have
been
attracting
attention
in
pharmaceutical
sciences
for
enhanced
drug
bioavailability
and
targeted
delivery.
Specifically,
these
can
enhance
the
solubility
of
poorly
water-soluble
drugs,
protect
therapeutic
agents
from
degradation,
prolong
circulation
time
body,
control
release,
facilitate
precise
targeting
drugs
to
specific
tissues
or
cells.
However,
once
administered
into
nanoparticles
often
encounter
significant
challenges
that
affect
their
efficacy
safety,
such
as
issues
with
stability,
biocompatibility,
targeting.
The
surface
properties
are
one
most
important
features
they
greatly
influence
interactions
between
themselves
biological
targets.
Key
characteristics,
charge,
hydrophobicity,
presence
functional
groups,
determine
how
behave
environments,
thereby
influencing
cellular
uptake,
ability
avoid
immune
clearance.
Modification
nanoparticle
has
shown
be
an
effective
approach
modulate
physicochemical
nanoparticles,
achieving
desired
vivo
.
This
review
aims
summarize
recent
advances
decoration
emphasis
on
improved
colloidal
reduced
toxicity,
future
perspectives
modification
approaches
also
discussed.
Frontiers in Nanotechnology,
Год журнала:
2024,
Номер
6
Опубликована: Окт. 21, 2024
Nanoparticles
are
attractive
therapeutic
tools
due
to
their
distinctive
characteristics,
including
more
accurate
drug
delivery,
improved
bioavailability,
and
enhanced
targeted
therapy.
This
review
offers
a
comprehensive
analysis
of
the
potentials
cutting-edge
nanoparticles
as
demonstrated
in
human
clinical
trials,
based
on
empirical
evidence.
Through
systematic
searches
major
scientific
databases,
relevant
studies
published
up
March
2024
were
included,
focusing
trials
utilizing
advanced
for
purposes.
The
discusses
diverse
applications
oncology,
infectious
diseases,
neurology,
other
medical
fields.
Additionally,
it
scrutinizes
safety
profiles,
efficacy
outcomes,
challenges
associated
with
nanoparticle-based
therapies.
findings
underscore
significant
progress
translating
nanoparticle
research
into
practice
highlight
potential
these
innovative
platforms
revolutionize
treatments.
contributes
valuable
insights
growing
field
therapeutics,
fostering
deeper
understanding
implications
practice.
Pharmaceutics,
Год журнала:
2025,
Номер
17(1), С. 121 - 121
Опубликована: Янв. 16, 2025
In
the
21st
century,
thanks
to
advances
in
biotechnology
and
developing
pharmaceutical
technology,
significant
progress
is
being
made
effective
drug
design.
Drug
targeting
aims
ensure
that
acts
only
pathological
area;
it
defined
as
ability
accumulate
selectively
quantitatively
target
tissue
or
organ,
regardless
of
chemical
structure
active
substance
method
administration.
With
targeting,
conventional,
biotechnological
gene-derived
drugs
body’s
organs,
tissues,
cells
can
be
transported
specific
regions.
These
systems
serve
carriers
regulate
timing
release.
Despite
having
many
advantageous
features,
these
have
limitations
thoroughly
treating
complex
diseases
such
cancer.
Therefore,
combining
with
nanoparticle
technologies
imperative
treat
cancer
at
both
local
systemic
levels
effectively.
The
nanocarrier-based
delivery
involves
encapsulating
target-specific
molecules
into
polymeric
vesicular
systems.
Various
(DDS)
were
investigated
discussed
this
review
article.
first
part
passive
systems,
hydrogels,
thermoplastics,
microdevices
transdermal-based
second
carrier
nanobiotechnology
(carbon
nanotubes,
nanoparticles,
coated,
pegylated,
solid
lipid
nanoparticles
smart
nanogels).
third
part,
advantages
discussed,
finally,
market
research
commercial
used
nanotechnological
approaches
was
included.
Frontiers in Neuroscience,
Год журнала:
2022,
Номер
16
Опубликована: Авг. 4, 2022
Alzheimer's
disease
(AD),
the
most
common
form
of
dementia,
is
a
progressive
and
multifactorial
neurodegenerative
disorder
whose
primary
causes
are
mostly
unknown.
Due
to
increase
in
life
expectancy
world
population,
including
developing
countries,
AD,
incidence
rises
dramatically
with
age,
at
forefront
among
diseases.
Moreover,
definitive
cure
not
yet
within
reach,
imposing
substantial
medical
public
health
burdens
every
latitude.
Therefore,
effort
devise
novel
effective
therapeutic
strategies
still
paramount
importance.
Genetic,
functional,
structural
biochemical
studies
all
indicate
that
new
efficacious
drug
delivery
interfere
different
levels
various
cellular
molecular
targets.
Over
last
few
decades,
development
nanomedicine
preclinical
stage
has
shown
progress
fast
pace,
thus
paving
way
for
its
potential
impact
on
human
improving
prevention,
diagnosis,
treatment
age-related
disorders,
AD.
Clinical
translation
nano-based
therapeutics,
despite
current
limitations,
may
present
important
advantages
innovation
be
exploited
neuroscience
field
as
well.
In
this
state-of-the-art
review
article,
we
promising
applications
polymeric
nanoparticle-mediated
bypassing
blood-brain
barrier
AD
models
boost
pharmacological
safety
efficacy.
particular,
strategic
chemical
functionalization
nanocarriers
could
successfully
employed
treating
thoroughly
described.
Emphasis
also
placed
nanotheranostics
both
diagnostic
tool
targeted
treatments.
Our
highlights
emerging
role
management
providing
readers
an
overview
nanostrategies
currently
available
develop
future
against
chronic
disease.
Pharmaceutics,
Год журнала:
2023,
Номер
15(3), С. 746 - 746
Опубликована: Фев. 23, 2023
Nanomedicine
is
currently
focused
on
the
design
and
development
of
nanocarriers
that
enhance
drug
delivery
to
brain
address
unmet
clinical
needs
for
treating
neuropsychiatric
disorders
neurological
diseases.
Polymer
lipid-based
carriers
are
advantageous
central
nervous
system
(CNS)
due
their
safety
profiles,
drug-loading
capacity,
controlled-release
properties.
nanoparticles
(NPs)
reported
penetrate
blood–brain
barrier
(BBB)
have
been
extensively
assessed
in
vitro
animal
models
glioblastoma,
epilepsy,
neurodegenerative
disease.
Since
approval
by
Food
Drug
Administration
(FDA)
intranasal
esketamine
treatment
major
depressive
disorder,
administration
has
emerged
as
an
attractive
route
bypass
BBB
CNS.
NPs
can
be
specifically
designed
tailoring
size
coating
with
mucoadhesive
agents
or
other
moieties
promote
transport
across
nasal
mucosa.
In
this
review,
unique
characteristics
polymeric
desirable
explored
addition
potential
repurposing
CNS
disorders.
Progress
using
nanostructures
treatments
various
diseases
also
described.
Carbohydrate Polymer Technologies and Applications,
Год журнала:
2024,
Номер
7, С. 100427 - 100427
Опубликована: Янв. 8, 2024
The
focus
of
this
review
is
on
chitosan
and
the
functionalization
nanoparticles
using
chlorotoxin
as
a
targeting
agent
in
drug
delivery
treatment
glioma.
Chitosan
has
been
characterized
most
commonly
used
polymer
for
brain
with
highest
bioadhesive
biocompatible
properties.
long
chain
amino-polysaccharide
obtained
by
alkaline
deacetylation
chitin
polysaccharide,
natural
component
crab
shells.
It
was
shown
to
have
many
beneficial
properties
such
antifungal,
antibacterial,
tissue
repair
or
neuroprotective.
advantage
chitosan-drug
based
that
it
biodegradable,
breaking
down
amino
acids,
readily
absorbed
safe
use.
In
addition,
mucoadhesive
affinity
MUC1
(CD227).
This
property
evaluated
us
previously
based-drug
system
tumor
cells.
vehicle
various
systems
including
those
glioma
glioblastoma
Glioma
highly
aggressive
invasive
low
patient's
survival
currently
no
effective
therapies
beside
standard
surgery,
radiation
chemotherapy.
Chlorotoxin
36
acids
peptide
originally
purified
from
venom
scorpion
Leiurus
quinquestriatus.
can
be
synthetically
manufactured
first
an
neuroectodermal
cells
later
also
several
other
types
tumors.
target
vitro
vivo
well
clinical
studies.
Conjugated
131-I
administered
intravenously
its
were
trials
treating
glioblastoma.
Recently,
applied
models
detection
polymeric
functionalize
their
specifically
