Frontiers in Bioengineering and Biotechnology,
Год журнала:
2025,
Номер
12
Опубликована: Янв. 22, 2025
Cerebrovascular
imaging
is
essential
for
the
diagnosis,
treatment,
and
prognosis
of
cerebrovascular
disease,
including
stroke,
aneurysms,
vascular
malformations.
Conventional
techniques
such
as
MRI,
CT,
DSA
ultrasound
have
their
own
strengths
limitations,
particularly
in
terms
resolution,
contrast
safety.
Recent
advances
nanotechnology
offer
new
opportunities
improved
imaging.
Nanomaterials,
metallic
nanoparticles,
magnetic
quantum
dots,
carbon-based
nanomaterials,
polymer
show
great
potential
due
to
unique
physical,
chemical,
biological
properties.
This
review
summarizes
recent
advanced
nanomaterials
applications
various
techniques,
discusses
challenges
future
research
directions.
The
aim
provide
valuable
insights
researchers
facilitate
development
clinical
application
these
innovative
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(14), С. 11722 - 11722
Опубликована: Июль 21, 2023
The
development
of
paclitaxel-loaded
polymeric
nanoparticles
for
the
treatment
brain
tumors
was
investigated.
Poly(lactide-glycolide)
(PLGA)
containing
10%
w/w
paclitaxel
with
a
particle
size
216
nm
were
administered
through
intranasal
and
intravenous
routes
to
male
Sprague-Dawley
rats
at
dose
5
mg/kg.
Both
administration
showed
appreciable
accumulation
in
tissue,
liver,
kidney
without
any
sign
toxicity.
anti-proliferative
effect
on
glioblastoma
tumor
cells
comparable
that
free
paclitaxel.
As
a
form
of
dementia,
Alzheimer's
disease
(AD)
suffers
from
no
efficacious
cure,
yet
AD
treatment
is
still
imperative,
as
it
ameliorates
the
symptoms
or
prevents
deteriorating
maintains
current
status
to
longest
extent.
The
human
brain
most
sensitive
and
complex
organ
in
body,
which
protected
by
blood-brain
barrier
(BBB).
This
induces
difficulty
curing
drugs
nanomaterials
that
are
much
inhibited
reaching
lesion
site.
Thus,
BBB
crossing
capability
drug
delivery
system
remains
significant
challenge
development
neurological
therapeutics.
Fortunately,
nano-enabled
systems
possess
promising
potential
achieve
multifunctional
diagnostics/therapeutics
against
various
targets
owing
their
intriguing
advantages
nanocarriers,
including
easy
multifunctionalization
on
surfaces,
high
surface-to-volume
ratio
with
large
payloads,
ability
cross
BBB,
making
them
capable
conquering
limitations
conventional
candidates.
review,
focuses
diagnosis
treatment,
will
provide
an
insightful
vision
conducive
AD-related
nanomaterials.
ACS Biomaterials Science & Engineering,
Год журнала:
2023,
Номер
9(3), С. 1224 - 1242
Опубликована: Фев. 8, 2023
Imaging
plays
an
integral
role
in
diagnostics
and
treatment
monitoring
for
conditions
affecting
the
brain;
enhanced
brain
imaging
capabilities
will
improve
upon
both
while
increasing
general
understanding
of
how
works.
T1-weighted
magnetic
resonance
is
preferred
modality
imaging.
Commercially
available
contrast
agents,
which
are
often
required
to
render
readable
images,
have
considerable
toxicity
concerns.
In
recent
years,
much
progress
has
been
made
developing
new
agents
based
on
features
gadolinium,
iron,
or
magnesium.
Nanotechnological
approaches
these
systems
allow
protected
integration
potentially
harmful
metals
with
added
benefits
like
reduced
dosage
improved
transport.
Polymeric
enhancement
each
design
further
improves
biocompatibility
allowing
specific
targeting.
This
review
outlines
research
polymeric
nanomedicine
designs
that
evaluated
performance
brain.
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
179, С. 117372 - 117372
Опубликована: Авг. 28, 2024
Polymeric
nanoparticles
have
emerged
as
promising
contenders
for
addressing
the
intricate
challenges
encountered
in
brain
tumor
therapy
due
to
their
distinctive
attributes,
including
adjustable
size,
biocompatibility,
and
controlled
drug
release
kinetics.
This
review
comprehensively
delves
into
latest
developments
synthesizing,
characterizing,
applying
polymeric
explicitly
tailored
therapy.
Various
synthesis
methodologies,
such
emulsion
polymerization,
nanoprecipitation,
template-assisted
fabrication,
are
scrutinized
within
context
of
targeting,
elucidating
advantages
limitations
concerning
traversing
blood-brain
barrier.
Furthermore,
strategies
pertaining
surface
modification
functionalization
expounded
upon
augment
stability,
targeting
prowess
amidst
milieu
microenvironment.
Characterization
techniques
encompassing
dynamic
light
scattering,
transmission
electron
microscopy,
spectroscopic
methods
evaluate
physicochemical
attributes
engineered
Moreover,
a
comprehensive
exploration
manifold
applications
delivery,
gene
therapy,
imaging,
combination
therapies
tumours
is
undertaken.
Special
emphasis
placed
on
encapsulation
diverse
therapeutics
nanoparticles,
thereby
shielding
them
from
degradation
enabling
precise
brain.
Additionally,
recent
advancements
stimuli-responsive
multifunctional
probed
potential
personalized
medicine
theranostics
tumours.
In
essence,
this
furnishes
an
all-encompassing
overview
strides
made
tailoring
illuminating
synthesis,
characterization,
multifaceted
application.
