Biomaterials Advances,
Год журнала:
2023,
Номер
153, С. 213582 - 213582
Опубликована: Авг. 9, 2023
The
anticancer
potential
of
quercetin
(Q),
a
plant-derived
flavonoid,
and
underlining
molecular
mechanisms
are
widely
documented
in
cellular
models
vitro.
However,
biomedical
applications
Q
limited
due
to
its
low
bioavailability
hydrophilicity.
In
the
present
study,
electrospinning
approach
was
used
obtain
polylactide
(PLA)
PLA
polyethylene
oxide
(PEO)-based
micro-
nanofibers
containing
Q,
namely
PLA/Q
PLA/PEO/Q,
respectively,
form
non-woven
fabrics.
structure
physico-chemical
properties
Q-loaded
fibers
were
characterized
by
scanning
electron
atomic
force
microscopy
(SEM
AFM),
X-ray
powder
diffraction
(XRD),
differential
calorimetry
(DSC),
goniometry
FTIR
Raman
spectroscopy.
action
PLA/PEO/Q
revealed
using
two
types
cancer
nine
cell
lines,
osteosarcoma
(MG-63,
U-2
OS,
SaOS-2
cells)
breast
(SK-BR-3,
MCF-7,
MDA-MB-231,
MDA-MB-468,
Hs
578T,
BT-20
cells).
activity
more
pronounced
than
free
Q.
promoted
cycle
arrest,
oxidative
stress
apoptotic
death
that
not
overcome
heat
shock
protein
(HSP)-mediated
adaptive
response.
biocompatible
safe,
as
judged
vitro
testing
normal
fibroblasts.
We
postulate
with
releasing
can
be
considered
novel
efficient
nano-system
deliver
eliminate
phenotypically
different
cells.
Journal of Drug Delivery Science and Technology,
Год журнала:
2023,
Номер
90, С. 105156 - 105156
Опубликована: Ноя. 10, 2023
Electrospinning
is
acknowledged
as
a
versatile
technique
for
producing
polymer
nanofibers.
Various
methods,
such
template
synthesis,
self-assembly,
phase
separation,
and
drawing,
have
been
employed
to
create
However,
due
its
simplicity,
adaptability,
the
inherently
high
surface
area-to-volume
ratio
in
electrospun
fibers,
electrospinning
has
emerged
most
suitable
method
nanofiber
fabrication.
This
review
delves
into
mechanisms
of
techniques
establishes
how
overcomes
challenges
presented
by
other
nanofabrication
methods.
The
explores
principles
electrospinning,
processing
parameters,
their
effects
on
resulting
fibers.
It
also
discusses
properties
selection
polymers
used
highlighting
various
types
commonly
pharmaceutical
applications.
Additionally,
covers
different
configurations,
discussing
impact
drug
release
profiles,
along
with
respective
advantages
disadvantages.
recent
applications
enhancing
outcomes
are
examined,
addressing
crucial
aspects
field,
improving
dissolution
rates,
masking
undesirable
tastes,
enabling
delivery
through
systems.
In
summary,
this
article
provides
comprehensive
understanding
pivotal
role
advancing
approaches.
Journal of Composites Science,
Год журнала:
2024,
Номер
8(1), С. 32 - 32
Опубликована: Янв. 15, 2024
Polymeric
nanofibers
have
emerged
as
a
captivating
medium
for
crafting
structures
with
biomedical
applications.
Spinning
methods
garnered
substantial
attention
in
the
context
of
medical
applications
and
neural
tissue
engineering,
ultimately
leading
to
production
polymer
fibers.
In
comparison
microfibers,
boasting
nanometer-scale
diameters
offer
significantly
larger
surface
areas,
facilitating
enhanced
functionalization.
Consequently,
nanofiber
mats
are
presently
undergoing
rigorous
evaluation
myriad
applications,
including
filters,
scaffolds
protective
equipment,
reinforcement
composite
materials,
sensors.
This
review
offers
an
exhaustive
overview
latest
advancements
processing
characterization.
Additionally,
it
engages
discourse
regarding
research
challenges,
forthcoming
developments
production,
diverse
types
its
Electrospinning
has
been
used
convert
broad
range
polymers
into
nanoparticle
nanofibers,
may
be
only
approach
significant
potential
industrial
manufacturing.
The
basics
these
spinning
techniques,
highlighting
uses
well
nanostructured
fibers
drug
delivery,
disease
modeling,
regenerative
medicine,
bio-sensing
explored.
Fibers,
Год журнала:
2024,
Номер
12(3), С. 26 - 26
Опубликована: Март 12, 2024
This
review
is
focused
on
the
recent
development
of
various
chitosan-based
nanofibers
(membranes,
patches,
mats,
and
scaffolds)
that
have
been
designed
into
core
shell
structures
using
emulsion
coaxial
electrospinning
techniques.
Chitosan,
a
promising
polysaccharide
derived
from
natural
sources,
holds
potential
for
diverse
applications,
including
nanofiber
production,
aimed
at
fostering
sustainability.
Core/shell
offer
appealing
features,
drug
encapsulation
sustained
release
capabilities,
with
higher
efficiency
than
uniaxial
fibers.
The
fabrication
core/shell
nanofibers,
co-spinning
agents
spinning
parameters,
such
as
voltage,
needle
size,
flow
rate,
distance
tip
to
collector,
temperature,
humidity,
summarized
in
this
work.
also
explores
updated
applications
fields,
textiles,
medical
dressings,
systems,
filtration
membranes,
food
packaging.
It
highlights
current
advancements
produced
via
innovative
insights
presented
literature
challenges
associated
these
sustainable
materials
are
thoroughly
examined,
offering
valuable
contributions
field.
Polymers,
Год журнала:
2025,
Номер
17(4), С. 435 - 435
Опубликована: Фев. 7, 2025
Drug
delivery
systems
have
revolutionized
traditional
drug
administration
methods
by
addressing
various
challenges,
such
as
enhancing
solubility,
prolonging
effectiveness,
minimizing
adverse
effects,
and
preserving
potency.
Nanotechnology-based
systems,
particularly
nanoparticles
(NPs)
nanofibers
(NFs),
emerged
promising
solutions
for
biomedicine
delivery.
NFs,
with
their
ability
to
mimic
the
porous
fibrous
structures
of
biological
tissues,
garnered
significant
interest
in
drug-delivering
applications.
Biopolymers
gelatin
(Ge)
chitosan
(CH)
gained
much
more
attention
due
biocompatibility,
biodegradability,
versatility
biomedical
CH
exhibits
exceptional
anti-bacterial
activity,
wound
healing
capabilities,
whereas
Ge
provides
good
biocompatibility
cell
adhesion
properties.
Ge/CH-based
NFs
stimulate
cellular
connections
facilitate
tissue
regeneration
owing
structural
resemblance
extracellular
matrix.
This
review
explores
additive
preparation,
including
electrospinning,
force
pinning,
template
synthesis,
focusing
on
electrospinning
factors
influencing
fiber
structure.
The
properties
CH,
role
release,
formulation
strategies,
characterization
techniques
electrospun
fibers
are
discussed.
Furthermore,
this
addresses
applications
delivering
active
moieties
management
orthopedics
regulatory
considerations,
along
challenges
related
them.
Thus,
aims
provide
a
comprehensive
overview
potential
Chemistry of Materials,
Год журнала:
2023,
Номер
36(1), С. 8 - 27
Опубликована: Дек. 18, 2023
The
field
of
hybrid
materials
has
grown
so
wildly
in
the
last
30
years
that
writing
a
comprehensive
review
turned
into
an
impossible
mission.
Yet,
need
for
general
view
remains,
and
it
would
be
certainly
useful
to
draw
scientific
technological
map
connecting
dots
very
different
subfields
materials,
which
could
relate
essential
common
characteristics
these
fascinating
while
providing
overview
combinations,
synthetic
approaches,
final
applications
formulated
this
field,
become
whole
world.
That
is
why
we
decided
write
metareview,
is,
reviews
provide
eagle's
eye
complex
varied
landscape
nevertheless
share
driving
force:
power
hybridization.
Advanced Engineering Materials,
Год журнала:
2023,
Номер
26(1)
Опубликована: Ноя. 14, 2023
Electrospinning
is
a
prominent
technique
for
micro/nanofiber
production
and
has
received
significant
attention
in
the
21
st
century.
It
enables
of
ultrafine
fibers
using
variety
polymers,
including
synthetic,
natural,
hybrid
materials.
Electrospun
nanofibers
(NFs)
possess
unique
properties
such
as
high
surface‐to‐volume
ratio,
tunable
pore
structures,
customizable
composition,
making
them
highly
desirable
various
fields
biomedical
science,
textiles,
sensors,
filters,
energy,
packaging.
Herein,
particular
will
be
given
to
application
NFs
fields.
The
use
delivery
drugs,
growth
factors,
proteins,
nanoparticles,
etc.,
holds
promise
field
science.
To
combine
these
compounds
with
NFs,
electrospinning
techniques
have
been
developed
outstanding
improvements,
based
on
requirements
type,
different
processes
are
favored.
In
this
review,
most
common
drug
loading
methods
into
generally
used
synthetic/natural
polymers
NF
production,
their
systems,
tissue
engineering,
wound
dressing
mentioned.
Finally,
challenges
future
perspectives
above
mentioned
applications
discussed.
Advanced Sensor and Energy Materials,
Год журнала:
2024,
Номер
3(2), С. 100093 - 100093
Опубликована: Фев. 24, 2024
The
advancement
of
gas
sensor
technology
over
the
past
decades
has
led
to
remarkable
progress
and
achievements
in
pollution
control
environmental
protection.
Compared
with
other
sensing
materials,
electrospun
nanofibers
have
attracted
significant
attention,
which
is
mainly
due
their
unique
characteristics,
including
but
not
limited
high
surface
area,
easy
structure
design,
facile
facility
setup,
multifunctional
properties,
etc.,
making
them
outstanding
candidates
for
potential
applications
this
field.
This
review
provides
an
overview
sensors,
concentrating
on
carbon
monoxide,
hydrogen,
dioxide,
hydrogen
sulfide,
ammonia,
nitrogen
oxides,
oxygen,
volatile
organic
compounds.
It
begins
a
brief
introduction
materials
advantages
along
ongoing
research.
principles
electrospinning
are
then
discussed.
Afterward,
corresponding
properties
diverse
sensors
thoroughly
reviewed.
Finally,
future
vision
regarding
challenges
perspectives
area
proposed.
extensive
comprehensive
reference
utilize
advanced
generate
novel
facilitating
performance
high-demand
areas.
