Опубликована: Янв. 1, 2024
Язык: Английский
Molecules, Год журнала: 2023, Номер 28(20), С. 7039 - 7039
Опубликована: Окт. 12, 2023
Large bone defects due to trauma, infections, and tumors are difficult heal spontaneously by the body’s repair mechanisms have become a major hindrance people’s daily lives economic development. However, autologous allogeneic grafts, with their lack of donors, more invasive surgery, immune rejection, potential viral transmission, hinder development repair. Hydrogel tissue bioengineered scaffolds gained widespread attention in field good biocompatibility three-dimensional network structure that facilitates cell adhesion proliferation. In addition, loading natural products nanoparticles incorporating them into hydrogel is one most effective strategies promote bioactivity limitations products. Therefore, this paper presents brief review application hydrogels different gel-forming properties, matrices, nanoparticle-loaded loaded incorporated for defect recent years.
Язык: Английский
Процитировано
28
Gels, Год журнала: 2024, Номер 10(11), С. 693 - 693
Опубликована: Окт. 25, 2024
Hydrogels are known for their high water retention capacity and biocompatibility have become essential materials in tissue engineering drug delivery systems. This review explores recent advancements hydrogel technology, focusing on innovative types such as self-healing, tough, smart, hybrid hydrogels, each engineered to overcome the limitations of conventional hydrogels. Self-healing hydrogels can autonomously repair structural damage, making them well-suited applications dynamic biomedical environments. Tough designed with enhanced mechanical properties, enabling use load-bearing cartilage regeneration. Smart respond external stimuli, including changes pH, temperature, electromagnetic fields, ideal controlled release tailored specific medical needs. Hybrid made from both natural synthetic polymers, combine bioactivity resilience, which is particularly valuable complex tissues. Despite these innovations, challenges optimizing biocompatibility, adjusting degradation rates, scaling up production remain. provides an in-depth analysis emerging technologies, highlighting transformative potential while outlining future directions development applications.
Язык: Английский
Процитировано
13
Chemistry of Materials, Год журнала: 2024, Номер 36(3), С. 1054 - 1087
Опубликована: Янв. 16, 2024
The field of tissue engineering and regenerative medicine is rapidly advancing, with numerous novel intriguing biomimetic materials being reported. Hydrogels, due to their unique structure properties closely resembling biological tissues, stand as prime candidates for mimicking natural tissues in applications. In recent years, drawing inspiration from the intricate structures found soft researchers have successfully created a range hydrogels. These hydrogels been tailored diverse applications fields such biomedicine, engineering, flexible electronic devices, beyond. However, designing fabricating synthetic structures, dynamic microenvironment systems, integrated functionalities remains challenging. This article presents latest research progress macroscopic structural hydrogels, well along most construction strategies, key design principles, optimization mechanisms. It summarizes potential various domains repair, signal detection sensing, drug delivery, more. Lastly, challenges future development directions preparation application are outlined.
Язык: Английский
Процитировано
8
Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials, Год журнала: 2024, Номер 158, С. 106674 - 106674
Опубликована: Июль 24, 2024
Язык: Английский
Процитировано
8
Macromolecular Rapid Communications, Год журнала: 2024, Номер unknown
Опубликована: Июнь 8, 2024
Abstract Soft actuators are one of the most promising technological advancements with potential solutions to diverse fields’ day‐to‐day challenges. derived from hydrogel materials possess unique features such as flexibility, responsiveness stimuli, and intricate deformations, making them ideal for soft robotics, artificial muscles, biomedical applications. This review provides an overview material composition design techniques actuators, exploring 3D printing, photopolymerization, cross‐linking, microfabrication methods improved actuation. It examines applications in biomedical, bioinspired systems, microfluidics, lab‐on‐a‐chip devices, environmental, energy systems. Finally, it discusses challenges, opportunities, advancements, regulatory aspects related actuators.
Язык: Английский
Процитировано
7
Biomacromolecules, Год журнала: 2024, Номер 25(6), С. 3345 - 3359
Опубликована: Май 3, 2024
The management of diabetic ulcers poses a significant challenge worldwide, and persistent hyperglycemia makes patients susceptible to bacterial infections. Unfortunately, the overuse antibiotics may lead drug resistance prolonged infections, contributing chronic inflammation hindering healing process. To address these issues, photothermal therapy technique was incorporated in preparation wound dressings. This innovative solution involved formulation self-healing injectable hydrogel matrix based on Schiff base structure formed between oxidized Bletilla striata polysaccharide (BSP) hydroxypropyltrimethylammonium chloride chitosan. Furthermore, introduction CuO nanoparticles encapsulated polydopamine imparted excellent properties hydrogel, which promoted release berberine (BER) loaded boosted antibacterial performance. In addition providing reliable physical protection wound, developed integrated herbal components BSP BER, effectively accelerated closure via microenvironment regulation, including alleviated inflammatory reaction, stimulated re-epithelialization, reduced oxidative stress promising results from cell animal experiments. These impressive outcomes highlighted their clinical potential safeguarding against intrusion managing ulcers.
Язык: Английский
Процитировано
4
Journal of Polymers and the Environment, Год журнала: 2025, Номер unknown
Опубликована: Янв. 25, 2025
Язык: Английский
Процитировано
0
Journal of Cleaner Production, Год журнала: 2025, Номер unknown, С. 145265 - 145265
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Bioengineering, Год журнала: 2025, Номер 12(5), С. 434 - 434
Опубликована: Апрель 22, 2025
Background: Cartilage defects and injuries often lead to osteoarthritis, posing significant challenges for cartilage repair. Traditional treatments have limited efficacy, necessitating innovative therapeutic strategies. This study aimed develop an injectable hydrogel-based tissue engineering construct enhance regeneration by combining mesenchymal stem cells (MSCs) the small molecule drug kartogenin (KGN). Methods: An hydrogel was synthesized crosslinking carboxymethyl chitosan (CMC) with aldehyde-modified cellulose nanocrystals (DACNCs). KGN incorporated into during achieve sustained release. Three hydrogels varying CMC/DACNC molar ratios (MR = 0.11, 0.22, 0.33) were developed characterized their structural, mechanical, biocompatible properties. The optimal ratio further evaluated its ability support MSC viability differentiation in vitro. Additionally, signaling pathways (TGF-β, FOXO, PI3K-AKT) investigated elucidate underlying mechanisms. In vivo efficacy assessed using a rabbit femoral trochlear defect model. Results: higher exhibited increased compressive modulus, reduced swelling rate, superior biocompatibility, effectively promoting Signaling pathway analysis revealed activation of TGF-β, PI3K-AKT pathways, suggesting enhanced chondrogenic potential. experiments demonstrated that KGN-MSC-encapsulated significantly improved Conclusions: hydrogel, combined MSCs, synergistically both vitro vivo. highlights potential this as promising scaffold engineering, offering novel approach injuries.
Язык: Английский
Процитировано
0
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0