Regenerative Engineering and Translational Medicine, Год журнала: 2024, Номер unknown
Опубликована: Сен. 20, 2024
Язык: Английский
Polymers, Год журнала: 2024, Номер 16(10), С. 1351 - 1351
Опубликована: Май 10, 2024
Chitosan, a versatile biopolymer derived from chitin, has garnered significant attention in various biomedical applications due to its unique properties, such as biocompatibility, biodegradability, and mucoadhesiveness. This review provides an overview of the diverse chitosan derivatives antibacterial, anticancer, wound healing, tissue engineering fields. In antibacterial applications, exhibits potent antimicrobial properties by disrupting microbial membranes DNA, making it promising natural preservative agent against bacterial infections. Its role cancer therapy involves development chitosan-based nanocarriers for targeted drug delivery, enhancing therapeutic efficacy while minimising side effects. Chitosan also plays crucial healing promoting cell proliferation, angiogenesis, regulating inflammatory responses. Additionally, serves multifunctional scaffold engineering, facilitating regeneration tissues cartilage, bone, neural adhesion proliferation. The extensive range pharmaceutical sciences is not only highlighted comprehensive scope this review, but establishes fundamental component forthcoming research biomedicine.
Язык: Английский
Процитировано
53
Discover Nano, Год журнала: 2024, Номер 19(1)
Опубликована: Сен. 3, 2024
Highlights CPL-AgNPs exhibited improved biomimetic attributes. Antibiotic resistance against pathogens were challenged through use of CPL-AgNPs. Supercapacitor application facile synthesized AgNPs for the first time demonstrated physical application.
Язык: Английский
Процитировано
16
Polymers, Год журнала: 2025, Номер 17(4), С. 435 - 435
Опубликована: Фев. 7, 2025
Drug delivery systems have revolutionized traditional drug administration methods by addressing various challenges, such as enhancing solubility, prolonging effectiveness, minimizing adverse effects, and preserving potency. Nanotechnology-based systems, particularly nanoparticles (NPs) nanofibers (NFs), emerged promising solutions for biomedicine delivery. NFs, with their ability to mimic the porous fibrous structures of biological tissues, garnered significant interest in drug-delivering applications. Biopolymers gelatin (Ge) chitosan (CH) gained much more attention due biocompatibility, biodegradability, versatility biomedical CH exhibits exceptional anti-bacterial activity, wound healing capabilities, whereas Ge provides good biocompatibility cell adhesion properties. Ge/CH-based NFs stimulate cellular connections facilitate tissue regeneration owing structural resemblance extracellular matrix. This review explores additive preparation, including electrospinning, force pinning, template synthesis, focusing on electrospinning factors influencing fiber structure. The properties CH, role release, formulation strategies, characterization techniques electrospun fibers are discussed. Furthermore, this addresses applications delivering active moieties management orthopedics regulatory considerations, along challenges related them. Thus, aims provide a comprehensive overview potential
Язык: Английский
Процитировано
3
Gels, Год журнала: 2023, Номер 9(7), С. 594 - 594
Опубликована: Июль 24, 2023
The main objective of this review is to provide a comprehensive overview the current evidence regarding use chitosan-based hydrogels manage skin infections. Chitosan, naturally occurring polysaccharide derived from chitin, possesses inherent antimicrobial properties, making it promising candidate for treating various dermal This follows systematic approach analyze relevant studies that have investigated effectiveness in context By examining available evidence, aims evaluate these hydrogels' overall efficacy, safety, and potential applications managing review's primary focus gather data different recent about combating infections; includes assessing their ability inhibit growth microorganisms reduce infection-related symptoms. Furthermore, also considers safety profile hydrogels, any adverse effects associated with use. evaluation crucial ensure can be safely utilized management infections without causing harm patients. healthcare professionals researchers understanding infection management. findings contribute informed decision-making development treatment strategies field.
Язык: Английский
Процитировано
34
Polymers, Год журнала: 2023, Номер 15(15), С. 3150 - 3150
Опубликована: Июль 25, 2023
Chitin, which may be the second-most common polymer after cellulose, is raw material of chitosan. Chitosan has been infused with various plant extracts and subsidiary polymers to improve its biological physiological properties. Chitosan's physicochemical properties are enhanced by blending, making them potential candidates that can utilized in multifunctional areas, including food processing, nutraceuticals, quality monitoring, packaging, storage. Chitosan-based biomaterials biocompatible, biodegradable, low toxic, mucoadhesive, regulate chemical release. Therefore, they used biomedical field. The present manuscript highlights application chitosan-based composites industries.
Язык: Английский
Процитировано
30
Molecular Cancer, Год журнала: 2024, Номер 23(1)
Опубликована: Окт. 31, 2024
Chitosan nanoparticles (NPs) are well-recognized as promising vehicles for delivering anticancer drugs due to their distinctive characteristics. They have the potential enclose hydrophobic molecules, thereby enhancing solubilities, permeabilities, and bioavailabilities; without use of surfactant, i.e., through surfactant-free solubilization. This allows higher drug concentrations at tumor sites, prevents excessive toxicity imparted by surfactants, could circumvent resistance. Moreover, biomedical engineers formulation scientists can also fabricate chitosan NPs slowly release agents. keeps site longer, makes therapy more effective, lowers frequency dosing. Notably, some types cancer cells (fallopian tube, epithelial tumors ovary, primary peritoneum; lung, kidney, ependymal brain, uterus, breast, colon, malignant pleural mesothelioma) overexpression folate receptors (FRs) on outer surface, which lets folate-drug conjugate–incorporated target kill them effectively. Strikingly, there is evidence suggesting that excessively produced FR&αgr (isoforms FR) stays consistent throughout treatment in ovarian endometrial cancer, indicating resistance conventional treatment; this regard, folate-anchored overcome it improve therapeutic outcomes. Interestingly, overly expressed FRs present only certain types, a biomarker predicting effectiveness FR-targeted therapy. On other hand, folate-modified enhance oral absorption medicines, especially drugs, pave way effective long-term low-dose metronomic scheduling poorly soluble permeable drugs. In review, we talked briefly about techniques used create, characterize, tailor chitosan-based NPs; delved deeper into applications folate-engineered treating various types. Schematic illustration ligand-drug incorporated its advantage cancer. Figure created with BioRender.Com.
Язык: Английский
Процитировано
13
Intelligent Pharmacy, Год журнала: 2024, Номер 2(3), С. 441 - 449
Опубликована: Фев. 9, 2024
Repaglinide (RPG) has a high rate of absorption from the gastrointestinal system after oral administration due to low log P value. Hence, in this study inotropic gelation process was used fabricate mucoadhesive microspheres RPG using biodegradable polymers such as guar gum, chitosan, and fenugreek seed mucilage. The were characterized tested vitro followed with glucose tolerance test on animals. Scanning electron microscopy images demonstrated that fabricated smooth spherical lack pores. particle size polydispersity index (PDI) microsphere observed 300 μm 0.349, respectively positive zeta potential 38.4 mV. results percentage yield swelling analysis 87.04 % 90.65 %, for optimized formulation an release capability 95.20 10 h. In addition, suggested successfully entrapped 94.86 ± 4.25 RPG. These clearly indicated fortified reduced blood level (hyperglycemia load 2 g/kg) significantly, compared marketed (0.25 mg/kg) h administration. Additionally, incorporated enable regulated over overall improvement anti-diabetic efficacy.
Язык: Английский
Процитировано
10
Nano-Structures & Nano-Objects, Год журнала: 2024, Номер 39, С. 101193 - 101193
Опубликована: Июнь 10, 2024
Язык: Английский
Процитировано
10
Food Research International, Год журнала: 2024, Номер 187, С. 114420 - 114420
Опубликована: Апрель 26, 2024
Язык: Английский
Процитировано
9
Regenerative Engineering and Translational Medicine, Год журнала: 2024, Номер unknown
Опубликована: Июль 19, 2024
Язык: Английский
Процитировано
9