Chitosan derived chito-oligosaccharides promote osteoblast differentiation and offer anti-osteoporotic potential: Molecular and morphological evidence from a zebrafish model

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 259, С. 129250 - 129250

Опубликована: Янв. 9, 2024

Язык: Английский

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Biogenic metallic nanoparticles: from green synthesis to clinical translation

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2024, Номер 397(11), С. 8603 - 8631

Опубликована: Июнь 27, 2024

Язык: Английский

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A review of chitosan in gene therapy: Developments and challenges

Carbohydrate Polymers, Год журнала: 2023, Номер 324, С. 121562 - 121562

Опубликована: Ноя. 4, 2023

Язык: Английский

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Modified polysaccharides for food packaging applications: A review

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 258, С. 128916 - 128916

Опубликована: Дек. 20, 2023

Язык: Английский

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Unveiling the potential of chitosan-coated lipid nanoparticles in drug delivery for management of critical illness: a review

Zeitschrift für Naturforschung C, Год журнала: 2024, Номер 79(5-6), С. 107 - 124

Опубликована: Май 1, 2024

Chitosan (CT), a natural, cationic, chemically stable molecule, biocompatible, biodegradable, nontoxic, polysaccharide derived from the deacetylation of chitin, has very uniquely surfaced as material promise for drug delivery and biomedical applications. For oral, ocular, cutaneous, pulmonary, nose-to-brain routes, CT-coated nanoparticles (CTCNPs) have numerous advantages, consisting improved controlled release, physicochemical stability, cell tissue interactions, increased bioavailability efficacy active ingredient. CTCNPs broad range therapeutic properties including anticancer, antiviral, antifungal, anti-inflammatory, antibacterial properties, treating neurological disorders, other diseases. This led to substantial research into many potential uses CT vehicle. also been employed in wide processes, bone cartilage regeneration, ocular periodontal heart wound healing. Additionally, used cosmeceutical, bioimaging, immunization, gene transfer exhibits number biological activities, which are basis its remarkable use vehicle, these activities covered detail this article. The alterations applied obtain necessary described.

Язык: Английский

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Biomaterials Comprising Implantable and Dermal Drug Delivery Targeting Brain in Management of Alzheimer’s Disease: A Review

Regenerative Engineering and Translational Medicine, Год журнала: 2024, Номер unknown

Опубликована: Март 4, 2024

Язык: Английский

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Navigating the future of cancer management through carbon nanodots: A review

Nano-Structures & Nano-Objects, Год журнала: 2024, Номер 39, С. 101217 - 101217

Опубликована: Июнь 17, 2024

Язык: Английский

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Metallic nanoparticles in cancer: Types, green synthesis, applications, tumor microenvironment and toxicity considerations

Journal of Drug Delivery Science and Technology, Год журнала: 2023, Номер 92, С. 105307 - 105307

Опубликована: Дек. 29, 2023

Язык: Английский

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Niacin-Loaded Liquid Crystal Nanoparticles Ameliorate Prostaglandin D2-Mediated Niacin-Induced Flushing and Hepatotoxicity

ACS Applied Nano Materials, Год журнала: 2024, Номер 7(1), С. 444 - 454

Опубликована: Янв. 2, 2024

Niacin plays a significant role in the therapy and management of mixed dyslipidemia. Nevertheless, its administration raw form is contraindicated due to potential adverse effects including hepatotoxicity cutaneous flushing. Prostaglandin D2 (PGD2) crucial signaling cascade niacin-induced To address reactions linked niacin therapy, we developed niacin-loaded lyotropic liquid crystal nanoparticle (NLCS) crafted explicitly for oral niacin. NLCSs were produced by disrupting cubic gel glyceryl monostearate (GMS). The nanoparticles demonstrated notable drug-loading capabilities with size approximately 255 ± 31.6 nm. Furthermore, NLCS displayed sustained release behavior, indicating their controlled prolonged drug delivery. Efficient encapsulation minimal interaction between other excipients evidenced through Fourier transform infrared X-ray diffraction studies, establishing high stability. In vitro studies suggested that had good antioxidant activity, swelling biocompatibility. Additionally, compared niacin, showed higher vivo therapeutic efficacy, less hepatotoxicity, more refined lipid profile, an improved complete blood count (CBC) profile. addition, it was shown animals treated lower PGD2 levels than those conclusion, our study highlights as promising strategy alleviate side direct ingestion pure These offer solution flushing-like symptoms positioning them viable option managing

Язык: Английский

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Sustainable sources of raw materials as substituting biomaterials for additive manufacturing of dental implants: a review

Deleted Journal, Год журнала: 2024, Номер 8(1)

Опубликована: Июнь 12, 2024

The increasing demand for dental implants and the necessity to develop sustainable biomaterials have increased interest in additive manufacturing (AM) of implants. implant industry has traditionally relied on materials such as metals alloys their mechanical properties biocompatibility. However, extraction processing these pose considerable environmental ethical challenges. This review explores emerging paradigm shift towards substituting traditional raw with AM also briefs about recent advancements techniques that enable fabrication using biomaterials. Using three dimensional (3D) printing technology allows precise customization while minimizing waste. Additionally, biodegradable polymers bio-ceramics shown promise supporting bone regeneration reducing ecological footprint production. Despite numerous challenges, this field study can fundamentally transform dentistry sector by impact effects related processes improving availability patients. Although preliminary reported studies are promising, further research required advance progress toward clinical applications AM.

Язык: Английский

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