Опубликована: Дек. 6, 2024
Язык: Английский
Journal of King Saud University - Science, Год журнала: 2024, Номер 36(8), С. 103307 - 103307
Опубликована: Июнь 14, 2024
This study aims to develop scaffolds (CCS, CCS-SeNPs, CCS-SA-SeNPs, and CCS-PET-SeNPs) with enhanced mechanical strength, thermal stability, antioxidant properties improve cell attachment proliferation of the C2C12 line for cardiac health applications. Collagen chitosan are popular biopolymers in tissue engineering their biocompatibility, biodegradability, support growth. Selenium nanoparticles (SeNPs) incorporated into antioxidant, anti-inflammatory, antimicrobial properties, which enhance regeneration. Sodium alginate pectin, natural polysaccharides, further modify these structural functional properties. Developing composite optimize biomaterial performance regenerative medicine. In present study, various types CCS-PET-SeNPs scaffolds) were prepared characterized using X-ray diffraction (XRD), Scanning Electron Microscopy Energy Dispersive Spectroscopy (SEM-EDX), Thermo-Gravimetric Analysis (TGA). The XRD data revealed that all displayed an amorphous structure. SEM analysis demonstrated CCS CCS-SA-SeNPs exhibit solid-walled metrics a smooth surface. EDX confirmed homogeneous Se distribution within scaffolds. tensile strength CCS, was found be 5.15 N, 4.77 4.05 4.01 respectively. Thermal stability assessments showed good maximum decomposition occurring at 250 °C. Furthermore, notable activity ∼ 57 %, compared scaffold's 42 %. Morphological studies cells on better SeNPs-enhanced Nucleus morphology remained unchanged, indicating no adverse effects from SeNPs. results indicate demonstrate enhancements efficacy. These advancements anticipated promote adhesion line, thereby emphasizing potential utility
Язык: Английский
Процитировано
6
Gels, Год журнала: 2024, Номер 10(7), С. 478 - 478
Опубликована: Июль 18, 2024
Oral diseases encompassing conditions such as oral cancer, periodontitis, and endodontic infections pose significant challenges due to the cavity's susceptibility pathogenic bacteria infectious agents. Saliva, a key component of environment, can compromise drug efficacy during disease treatment by diluting formulations reducing drug-site interactions. Thus, it is imperative develop effective delivery methods. Stimuli-responsive nanocomposite hydrogels offer promising solution adapting changes in environmental states, thereby enabling targeted delivery. These smart systems have potential enhance efficacy, minimize adverse reactions, reduce administration frequency, improve patient compliance, thus facilitating faster recovery. This review explores various types stimuli-responsive tailored for delivery, with specific focus on their applications managing diseases.
Язык: Английский
Процитировано
6
Gels, Год журнала: 2024, Номер 10(11), С. 689 - 689
Опубликована: Окт. 24, 2024
Stimuli-responsive nanocomposite gels combine the unique properties of hydrogels with those nanoparticles, thus avoiding suboptimal results single components and creating versatile, multi-functional platforms for therapeutic diagnostic applications. These hybrid materials are engineered to respond various internal external stimuli, such as temperature, pH, light, magnetic fields, enzymatic activity, allowing precise control over drug release, tissue regeneration, biosensing. Their responsiveness environmental cues permits personalized medicine approaches, providing dynamic interventions real-time capabilities. This review explores recent advances in stimuli-responsive gels' synthesis application, including delivery, engineering, diagnostics. Overall, these have significant clinical potential, future research is expected lead solutions address unmet medical needs.
Язык: Английский
Процитировано
5
Nanotechnology in the life sciences, Год журнала: 2025, Номер unknown, С. 131 - 181
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
The minerals, metals & materials series, Год журнала: 2025, Номер unknown, С. 683 - 692
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
ACS Biomaterials Science & Engineering, Год журнала: 2025, Номер unknown
Опубликована: Март 11, 2025
Roughly 1.71 billion people worldwide suffer from large bone abnormalities, which are the primary cause of disability. Traditional grafting procedures have several drawbacks that impair their therapeutic efficacy and restrict use in clinical settings. A great deal work has been done to create fresh, more potent strategies. Under these circumstances, a crucial technique for regeneration major lesions emerged: tissue engineering (BTE). BTE involves biomaterials can imitate natural design bone. To yet, no biological material able fully meet parameters perfect implantable material, even though varieties created investigated regeneration. Against this backdrop, researchers focused interest over past few years on subject nanotechnology nanostructures regenerative medicine. The ability nanoengineered particles overcome current constraints strategies─such as decreased cell proliferation differentiation, insufficient mechanical strength materials, production extrinsic factors required effective osteogenesis revolutionized field engineering. effects nanoparticles characteristics application materials main topics our review, summarizes most recent vitro vivo research context BTE.
Язык: Английский
Процитировано
0
Results in Surfaces and Interfaces, Год журнала: 2025, Номер unknown, С. 100481 - 100481
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Frontiers in Cellular and Infection Microbiology, Год журнала: 2025, Номер 15
Опубликована: Апрель 11, 2025
Bone marrow is vital for hematopoiesis, producing blood cells essential oxygen transport, immune defense, and clotting. However, disorders like leukemia, lymphoma, aplastic anemia, myelodysplastic syndromes can severely disrupt its function, leading to life-threatening complications. Traditional treatments, including chemotherapy stem cell transplants, have significantly improved patient outcomes but are often associated with severe side effects limitations, necessitating the exploration of safer, more targeted therapeutic strategies. Nanotechnology has emerged as a promising approach addressing these challenges, particularly in delivery nutraceuticals—bioactive compounds derived from food sources potential benefits. Despite their promise, nutraceuticals face clinical limitations due poor bioavailability, instability, inefficient target sites. Nanoparticles offer viable solution by enhancing stability, absorption, transport bone while minimizing systemic effects. This study explores range disorders, conventional treatment modalities, nanoparticles enhance nutraceutical-based therapies. By improving efficacy, could revolutionize disease management, providing patients effective less invasive options. These advancements represent significant step toward safer efficient approaches, ultimately prognosis overall health.
Язык: Английский
Процитировано
0
Frontiers in Bioengineering and Biotechnology, Год журнала: 2024, Номер 12
Опубликована: Авг. 15, 2024
Heart failure is a major health problem in which the heart unable to pump enough blood meet body’s needs. It progressive disease that becomes more severe over time and can be caused by variety of factors, including attack, cardiomyopathy valve disease. There are various methods cure this disease, has many complications risks. The advancement knowledge technology proposed new for diseases. One promising treatments tissue engineering. Tissue engineering field research aims create living tissues organs replace damaged or diseased tissue. goal improve cardiac function reduce need transplantation. This done using three important principles cells, biomaterials signals techniques cells such as electrospinning, hydrogel synthesis, decellularization, etc. diverse. Treating through still under development research, but it hoped there will no transplants invasive surgeries near future. In study, based on most recent years, we examine power treatment failure.
Язык: Английский
Процитировано
3
Materials Today Sustainability, Год журнала: 2024, Номер 28, С. 100975 - 100975
Опубликована: Сен. 6, 2024
Язык: Английский
Процитировано
3