Extracellular vesicles as tools and targets in therapy for diseases
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Фев. 5, 2024
Abstract
Extracellular
vesicles
(EVs)
are
nano-sized,
membranous
structures
secreted
into
the
extracellular
space.
They
exhibit
diverse
sizes,
contents,
and
surface
markers
ubiquitously
released
from
cells
under
normal
pathological
conditions.
Human
serum
is
a
rich
source
of
these
EVs,
though
their
isolation
proteins
non-EV
lipid
particles
poses
challenges.
These
transport
various
cellular
components
such
as
proteins,
mRNAs,
miRNAs,
DNA,
lipids
across
distances,
influencing
numerous
physiological
events,
including
those
within
tumor
microenvironment
(TME).
Their
pivotal
roles
in
communication
make
EVs
promising
candidates
for
therapeutic
agents,
drug
delivery
systems,
disease
biomarkers.
Especially
cancer
diagnostics,
EV
detection
can
pave
way
early
identification
offers
potential
diagnostic
Moreover,
subtypes
emerging
targeted
tools,
highlighting
clinical
significance.
The
need
non-invasive
biomarkers
to
monitor
biological
processes
purposes
remains
unfulfilled.
Tapping
unique
composition
could
unlock
advanced
avenues
future.
In
this
review,
we
discuss
detail
conditions,
cancers
(encompassing
head
neck,
lung,
gastric,
breast,
hepatocellular
carcinoma),
neurodegenerative
disorders,
diabetes,
viral
infections,
autoimmune
renal
diseases,
emphasizing
advancements
molecular
diagnostics
delivery.
Язык: Английский
Exosomes target HBV-host interactions to remodel the hepatic immune microenvironment
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Июнь 5, 2024
Chronic
hepatitis
B
poses
a
significant
global
burden,
modulating
immune
cells,
leading
to
chronic
inflammation
and
long-term
damage.
Due
its
hepatotropism,
the
virus
(HBV)
cannot
infect
other
cells.
The
mechanisms
underlying
intercellular
communication
among
different
liver
cells
in
HBV-infected
individuals
microenvironment
imbalance
remain
elusive.
Exosomes,
as
important
cargo
transportation
tools
between
hepatocytes
have
been
shown
assist
HBV
regulate
microenvironment.
However,
role
of
exosomes
has
only
gradually
received
attention
recent
years.
Minimal
literature
systematically
elaborated
on
reshaping
liver.
This
review
unfolds
sequentially
based
biological
processes
exosomes:
exosomes'
biogenesis,
release,
transport,
uptake
by
recipient
their
impact
We
delineate
how
influences
biogenesis
exosomes,
utilizing
exosomal
covert
transmission,
reshapes
hepatic
And
characteristics
functions
potential
applications
are
summarized
predicted.
Язык: Английский
Interplay of Extracellular Vesicles and TLR4 Signaling in Hepatocellular Carcinoma Pathophysiology and Therapeutics
Pharmaceutics,
Год журнала:
2023,
Номер
15(10), С. 2460 - 2460
Опубликована: Окт. 13, 2023
Hepatocellular
carcinoma
(HCC)
stands
as
a
significant
contributor
to
global
cancer-related
mortality.
Chronic
inflammation,
often
arising
from
diverse
sources
such
viral
hepatitis,
alcohol
misuse,
nonalcoholic
fatty
liver
disease
(NAFLD),
and
steatohepatitis
(NASH),
profoundly
influences
HCC
development.
Within
this
context,
the
interplay
of
extracellular
vesicles
(EVs)
gains
prominence.
EVs,
encompassing
exosomes
microvesicles,
mediate
cell-to-cell
communication
cargo
transfer,
impacting
various
biological
processes,
including
inflammation
cancer
progression.
Toll-like
receptor
4
(TLR4),
key
sentinel
innate
immune
system,
recognizes
both
pathogen-associated
molecular
patterns
(PAMPs)
damage-associated
(DAMPs),
thereby
triggering
signaling
cascades
pro-inflammatory
cytokine
release.
The
intricate
involvement
TLR4
pathway
in
chronic
pathogenesis
is
discussed
study.
Moreover,
we
delve
into
therapeutic
potential
modulating
using
EVs
novel
agents
for
HCC.
This
review
underscores
multifaceted
role
context
proposes
innovative
avenues
targeted
interventions
against
formidable
disease.
Язык: Английский
Bifidobacterium longum-Derived Extracellular Vesicles Prevent Hepatocellular Carcinoma by Modulating the TGF-β1/Smad Signaling in Mice
Frontiers in Bioscience-Landmark,
Год журнала:
2024,
Номер
29(7), С. 241 - 241
Опубликована: Июнь 28, 2024
The
involvement
of
gut
microbiota
in
carcinogenesis
has
gradually
been
highlighted
past
decades.
Bacteria
could
play
its
role
by
the
secretion
extracellular
vesicles
(EVs);
however,
interrelationship
between
bacterial
EVs
and
hepatocellular
carcinoma
(HCC)
development
not
investigated
much.
Язык: Английский
Extracellular Vesicles in Viral Liver Diseases
Viruses,
Год журнала:
2024,
Номер
16(11), С. 1785 - 1785
Опубликована: Ноя. 17, 2024
Extracellular
vesicles
(EVs)
are
bilayer
released
by
cells
in
the
microenvironment
of
liver
including
parenchymal
and
non-parenchymal
cells.
They
third
important
mechanism
communications
between
cells,
besides
secretion
cytokines
chemokines
direct
cell-to-cell
contact.
The
aim
this
review
is
to
discuss
role
EVs
viral
disease,
as
there
increasing
evidence
that
transportation
proteins,
all
types
RNA,
particles
complete
virions
implicated
pathogenesis
both
cirrhosis
viral-related
hepatocellular
carcinoma.
biogenesis
discussed
their
diseases
presented.
Their
use
diagnostic
prognostic
biomarkers
also
analyzed.
Most
importantly,
significance
possible
novel
treatment
strategies
for
fibrosis
carcinoma
presented,
although
available
data
based
on
experimental
clinical
trials
have
not
been
reported.
Язык: Английский
Proceedings of the 5th Meeting of Translational Hepatology, organized by the Spanish Association for the Study of the Liver (AEEH)
Gastroenterología y Hepatología,
Год журнала:
2024,
Номер
47(10), С. 502207 - 502207
Опубликована: Май 8, 2024
This
is
the
summary
report
of
5th
Translational
Hepatology
Meeting,
endorsed
by
Spanish
Association
for
Study
Liver
(AEEH)
and
held
in
Seville,
Spain,
October
2023.
The
meeting
aimed
to
provide
an
update
on
latest
advances
field
basic
translational
hepatology,
covering
different
molecular,
cellular,
pathophysiological
aspects
most
relevant
clinical
challenges
liver
pathologies.
includes
identification
novel
biomarkers
diagnostic
tools,
understanding
relevance
immune
response
inflammation
diseases,
characterization
current
medical
approaches
reverse
incorporation
molecular
insights
through
omics
techniques,
or
impact
toxic
metabolic
insults,
as
well
other
organ
crosstalk,
pathophysiology.
Este
es
el
informe
resumen
de
la
5ª
Reunión
Hepatología
Traslacional,
organizada
por
Asociación
Española
para
Estudio
del
Hígado
y
celebrada
en
Sevilla,
España,
octubre
La
reunión
tuvo
como
objetivo
proporcionar
una
actualización
sobre
los
últimos
avances
campo
hepatología
básica
traslacional,
cubriendo
diferentes
aspectos
moleculares,
celulares
fisiopatológicos
las
necesidades
clínicas
más
relevantes
patologías
hepáticas.
Esto
incluye
identificación
nuevos
biomarcadores
herramientas
diagnóstico,
comprensión
relevancia
respuesta
inmune
inflamación
enfermedades
hepáticas,
caracterización
nuevas
aproximaciones
revertir
incorporación
conocimientos
moleculares
a
través
enfoques
ómicos,
o
impacto
agentes
tóxicos
alteraciones
metabólicas,
así
interacción
con
otros
órganos,
fisiopatología
hígado.
Proceedings of the 5th Meeting of Translational Hepatology, organized by the Spanish Association for the Study of the Liver (AEEH)
Gastroenterología y Hepatología (English Edition),
Год журнала:
2024,
Номер
47(10), С. 502207 - 502207
Опубликована: Ноя. 27, 2024
Язык: Английский