
Gastroenterología y Hepatología (English Edition), Год журнала: 2024, Номер 47(10), С. 502207 - 502207
Опубликована: Ноя. 27, 2024
Язык: Английский
Gastroenterología y Hepatología (English Edition), Год журнала: 2024, Номер 47(10), С. 502207 - 502207
Опубликована: Ноя. 27, 2024
Язык: Английский
Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)
Опубликована: Фев. 5, 2024
Abstract Extracellular vesicles (EVs) are nano-sized, membranous structures secreted into the extracellular space. They exhibit diverse sizes, contents, and surface markers ubiquitously released from cells under normal pathological conditions. Human serum is a rich source of these EVs, though their isolation proteins non-EV lipid particles poses challenges. These transport various cellular components such as proteins, mRNAs, miRNAs, DNA, lipids across distances, influencing numerous physiological events, including those within tumor microenvironment (TME). Their pivotal roles in communication make EVs promising candidates for therapeutic agents, drug delivery systems, disease biomarkers. Especially cancer diagnostics, EV detection can pave way early identification offers potential diagnostic Moreover, subtypes emerging targeted tools, highlighting clinical significance. The need non-invasive biomarkers to monitor biological processes purposes remains unfulfilled. Tapping unique composition could unlock advanced avenues future. In this review, we discuss detail conditions, cancers (encompassing head neck, lung, gastric, breast, hepatocellular carcinoma), neurodegenerative disorders, diabetes, viral infections, autoimmune renal diseases, emphasizing advancements molecular diagnostics delivery.
Язык: Английский
Процитировано
326Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Июнь 5, 2024
Chronic hepatitis B poses a significant global burden, modulating immune cells, leading to chronic inflammation and long-term damage. Due its hepatotropism, the virus (HBV) cannot infect other cells. The mechanisms underlying intercellular communication among different liver cells in HBV-infected individuals microenvironment imbalance remain elusive. Exosomes, as important cargo transportation tools between hepatocytes have been shown assist HBV regulate microenvironment. However, role of exosomes has only gradually received attention recent years. Minimal literature systematically elaborated on reshaping liver. This review unfolds sequentially based biological processes exosomes: exosomes' biogenesis, release, transport, uptake by recipient their impact We delineate how influences biogenesis exosomes, utilizing exosomal covert transmission, reshapes hepatic And characteristics functions potential applications are summarized predicted.
Язык: Английский
Процитировано
6Pharmaceutics, Год журнала: 2023, Номер 15(10), С. 2460 - 2460
Опубликована: Окт. 13, 2023
Hepatocellular carcinoma (HCC) stands as a significant contributor to global cancer-related mortality. Chronic inflammation, often arising from diverse sources such viral hepatitis, alcohol misuse, nonalcoholic fatty liver disease (NAFLD), and steatohepatitis (NASH), profoundly influences HCC development. Within this context, the interplay of extracellular vesicles (EVs) gains prominence. EVs, encompassing exosomes microvesicles, mediate cell-to-cell communication cargo transfer, impacting various biological processes, including inflammation cancer progression. Toll-like receptor 4 (TLR4), key sentinel innate immune system, recognizes both pathogen-associated molecular patterns (PAMPs) damage-associated (DAMPs), thereby triggering signaling cascades pro-inflammatory cytokine release. The intricate involvement TLR4 pathway in chronic pathogenesis is discussed study. Moreover, we delve into therapeutic potential modulating using EVs novel agents for HCC. This review underscores multifaceted role context proposes innovative avenues targeted interventions against formidable disease.
Язык: Английский
Процитировано
7Frontiers in Bioscience-Landmark, Год журнала: 2024, Номер 29(7), С. 241 - 241
Опубликована: Июнь 28, 2024
The involvement of gut microbiota in carcinogenesis has gradually been highlighted past decades. Bacteria could play its role by the secretion extracellular vesicles (EVs); however, interrelationship between bacterial EVs and hepatocellular carcinoma (HCC) development not investigated much.
Язык: Английский
Процитировано
1Viruses, Год журнала: 2024, Номер 16(11), С. 1785 - 1785
Опубликована: Ноя. 17, 2024
Extracellular vesicles (EVs) are bilayer released by cells in the microenvironment of liver including parenchymal and non-parenchymal cells. They third important mechanism communications between cells, besides secretion cytokines chemokines direct cell-to-cell contact. The aim this review is to discuss role EVs viral disease, as there increasing evidence that transportation proteins, all types RNA, particles complete virions implicated pathogenesis both cirrhosis viral-related hepatocellular carcinoma. biogenesis discussed their diseases presented. Their use diagnostic prognostic biomarkers also analyzed. Most importantly, significance possible novel treatment strategies for fibrosis carcinoma presented, although available data based on experimental clinical trials have not been reported.
Язык: Английский
Процитировано
0Gastroenterología y Hepatología, Год журнала: 2024, Номер 47(10), С. 502207 - 502207
Опубликована: Май 8, 2024
This is the summary report of 5th Translational Hepatology Meeting, endorsed by Spanish Association for Study Liver (AEEH) and held in Seville, Spain, October 2023. The meeting aimed to provide an update on latest advances field basic translational hepatology, covering different molecular, cellular, pathophysiological aspects most relevant clinical challenges liver pathologies. includes identification novel biomarkers diagnostic tools, understanding relevance immune response inflammation diseases, characterization current medical approaches reverse incorporation molecular insights through omics techniques, or impact toxic metabolic insults, as well other organ crosstalk, pathophysiology. Este es el informe resumen de la 5ª Reunión Hepatología Traslacional, organizada por Asociación Española para Estudio del Hígado y celebrada en Sevilla, España, octubre La reunión tuvo como objetivo proporcionar una actualización sobre los últimos avances campo hepatología básica traslacional, cubriendo diferentes aspectos moleculares, celulares fisiopatológicos las necesidades clínicas más relevantes patologías hepáticas. Esto incluye identificación nuevos biomarcadores herramientas diagnóstico, comprensión relevancia respuesta inmune inflamación enfermedades hepáticas, caracterización nuevas aproximaciones revertir incorporación conocimientos moleculares a través enfoques ómicos, o impacto agentes tóxicos alteraciones metabólicas, así interacción con otros órganos, fisiopatología hígado.
Процитировано
0Gastroenterología y Hepatología (English Edition), Год журнала: 2024, Номер 47(10), С. 502207 - 502207
Опубликована: Ноя. 27, 2024
Язык: Английский
Процитировано
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