Anti-skin Aging Effects of Kale-derived Exosome-like Nanoparticles DOI Open Access
Shigeru Katayama

YAKUGAKU ZASSHI, Год журнала: 2024, Номер 145(1), С. 29 - 33

Опубликована: Дек. 31, 2024

In an aging society, there is a growing interest in functional foods that offer anti-aging benefits. Food-derived bioactive compounds such as carotenoids and polyphenols can enhance skin elasticity delay aging. However, the mechanisms by which these orally ingested directly impact are not fully understood. Recent studies on exosomes have suggested significant physiological functions, including their potential for intercellular communication. Similar to mammalian exosomes, plant-derived known roles, cross-kingdom communication, ability target specific organs animal models delivery vehicles. The authors been investigating effects of kale previously reported its benefits cognitive function mouse models. Long-term oral administration glucoraphanin-enriched suppresses senescence symptoms hair increases type I collagen antioxidant enzyme expression tissues, indicating role promoting health. Exosome-like nanoparticles (ELNs) from appear modulate extracellular matrix-related genes. Kale-derived ELNs exhibit great ameliorating aging, suggesting promote health through targeted cellular supporting use active natural compound nutraceuticals beverages.

Язык: Английский

Bioactive compounds and biological functions of medicinal plant-derived extracellular vesicles DOI Creative Commons
Siyu Hao,

Hongyu Yang,

Jiaojiao Hu

и другие.

Pharmacological Research, Год журнала: 2024, Номер 200, С. 107062 - 107062

Опубликована: Янв. 9, 2024

Extracellular vesicles (EVs) are tiny lipid bilayer-enclosed membrane particles released from a variety of cell types into the surrounding environment. These EVs have massive participated in cell-to-cell communication and interspecies communication. In recent years, plant-derived extracellular (PDEVs) "exosome-like" populations found distinct plants attracted widespread attention. Especially, research on medicinal (MPDEVs) increasing, which considered kind promising natural compound. This review summarizes current knowledge MPDEVs terms bioactive compounds, including small RNA, protein, lipid, metabolite, been surface and/or lumen MPDEVs. Moreover, both vitro vivo experiments shown that exert broad biomedical functions, such as anti-inflammatory, anticancer, antioxidant, modulate microbiota, etc. may be better substitute than animal-derived (ADEVs) because safety biocompatibility future.

Язык: Английский

Процитировано

18
Harnessing tomato-derived small extracellular vesicles as drug delivery system for cancer therapy DOI Creative Commons

Kartik Kumar Sarwareddy,

Anula Divyash Singh, Sreekanth Patnam

и другие.

Future Science OA, Год журнала: 2025, Номер 11(1)

Опубликована: Фев. 7, 2025

Aim This study aims to explore a sustainable and scalable approach using tomato fruit-derived sEVs (TsEVs) deliver calcitriol for enhanced anticancer effects, addressing challenges of low yield high costs associated with mammalian cell-derived sEVs.

Язык: Английский

Процитировано

2
Exosome-like nanovesicles derived from kale juice enhance collagen production by downregulating Smad7 in human skin fibroblasts DOI Creative Commons
P. J. Hsu,

Yuriko Kamijyo,

Emiri Koike

и другие.

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Фев. 10, 2025

Plant-derived exosome-like nanovesicles (ELNs) are critical mediators of cross-kingdom communication, modulating gene expression in animal cells despite their plant origin. In this study, we investigated the effects glucoraphanin-enriched kale (GEK)-derived ELNs (GELNs) on collagen production normal human dermal fibroblasts NB1RGB. The isolated from GEK juice powder had particle sizes similar to those typical exosomes. GELNs increased type I NB1RGB significantly. Microarray analysis demonstrated that GELN-derived total RNA upregulated genes related extracellular matrix formation, including involved synthesis. Further investigation revealed microRNA-enriched fraction promoted by inhibiting Smad7. These findings suggest and microRNA content enhance through downregulation

Язык: Английский

Процитировано

2
Recent Advances in the Isolation Strategies of Plant-Derived Exosomes and Their Therapeutic Applications DOI Creative Commons

Jeong‐Geon Mun,

Dandan Song, Ji‐Ye Kee

и другие.

Current Issues in Molecular Biology, Год журнала: 2025, Номер 47(3), С. 144 - 144

Опубликована: Фев. 22, 2025

Exosome-like nanovesicles (ELNs) derived from natural products are gaining attention as innovative therapeutic agents due to their biocompatibility, low immunogenicity, and capability transport bioactive molecules such proteins, lipids, nucleic acids. These plant-derived ELNs exhibit structural similarities with mammalian exosomes, making them suitable for drug delivery, microbiome-targeted therapies, regenerative medicine. Recent studies highlight potential in treating cancer, inflammation, metabolic disorders. Additionally, have applications cosmetics, agriculture, the food industry. This review combines latest advancements research on ELNs, focusing isolation techniques, pharmacological effects, applications. Although offer promising opportunities, several challenges must be addressed, including standardization, large-scale production, vivo efficacy. By summarizing cutting-edge suggesting future directions, we aim inspire further development of next-generation platforms.

Язык: Английский

Процитировано

2
Exosomes in Dermatological Research: Unveiling Their Multifaceted Role in Cellular Communication, Healing, and Disease Modulation DOI Creative Commons
Daniela Pinto,

Giammaria Giuliani,

Giorgia Mondadori

и другие.

Cosmetics, Год журнала: 2025, Номер 12(1), С. 16 - 16

Опубликована: Янв. 22, 2025

Exosomes, a subtype of extracellular vehicles (EVs), play pivotal role in cellular communication and have gained considerable attention dermatological research. Formed through the inward budding endosomal membrane, exosomes facilitate transfer proteins, lipids, nucleic acids, including microRNAs (miRNAs), thereby influencing behavior function recipient cells. These vesicles are secreted by various cell types, keratinocytes, crucial for maintaining skin homeostasis, regulating immune responses, promoting wound healing. Exosomes demonstrated therapeutic potential addressing conditions such as hair disorders, cancers photoaging enhanced regeneration reduced oxidative stress. However, they also implicated disease progression, with pathogens utilizing exosome release to evade host responses. Recent studies highlight diverse origins functions exosomes, suggesting their promise innovative agents dermatology. As research continues elucidate multifaceted roles, represent frontier understanding intercellular developing novel treatments skin-related diseases, underscoring impact on both health clinical applications. This review synthesizes existing literature biology isolation focus implications contexts.

Язык: Английский

Процитировано

1
Comparative analysis of exosomes isolated by ultracentrifugation and total exosome isolation reagent: a biophysical and physicochemical study DOI

Angel Mendonca,

Aparajita Acharjee,

Janardanan Subramonia Kumar

и другие.

Journal of Nanoparticle Research, Год журнала: 2025, Номер 27(2)

Опубликована: Янв. 24, 2025

Язык: Английский

Процитировано

1
Unlocking the Medicinal Potential of Plant-Derived Extracellular Vesicles: current Progress and Future Perspectives DOI Creative Commons
Xiaoliang Liu,

Kecheng Lou,

Y.‐H. Percival Zhang

и другие.

International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 4877 - 4892

Опубликована: Май 1, 2024

Abstract: Botanical preparations for herbal medicine have received more and attention from drug researchers, the extraction of active ingredients their successful clinical application become an important direction research in major pharmaceutical companies, but complexity extracts, multiple side effects, significant individual differences brought many difficulties to preparations. It is noteworthy that extracellular vesicles as biomolecules extracted medicinal plants are believed be useful treatment a variety diseases, including cancer, inflammation, regenerative-restorative degenerative which may provide new utilization In this review, we sort out recent advances plant discuss potential disease therapeutics. Finally, future challenges directions translation also discussed, expect continued development based on will facilitate Keywords: plant-derived vesicles, Chinese preparation, nanoparticle, delivery nanoplatforms, nanotherapeutics

Язык: Английский

Процитировано

9
Exosome-mediated delivery of siRNA molecules in cancer therapy: triumphs and challenges DOI Creative Commons
Philemon Ubanako, Sheefa Mirza, Paul Ruff

и другие.

Frontiers in Molecular Biosciences, Год журнала: 2024, Номер 11

Опубликована: Сен. 17, 2024

The discovery of novel and innovative therapeutic strategies for cancer treatment management remains a major global challenge. Exosomes are endogenous nanoscale extracellular vesicles that have garnered increasing attention as vehicles advanced drug delivery targeted therapy. attractive physicochemical biological properties exosomes, including increased permeability, biocompatibility, extended half-life in circulation, reduced toxicity immunogenicity, multiple functionalization strategies, made them preferred other diseases. Small interfering RNAs (siRNAs) remarkably able to target any known gene: an attribute harnessed knock down cancer-associated genes viable strategy management. Extensive research on exosome-mediated siRNAs targeting diverse types has yielded promising results anticancer therapy, with some formulations progressing through clinical trials. This review catalogs recent advances siRNA several cancer, the manifold benefits minimal drawbacks such systems. Additionally, we highlighted potential plant-derived exosomes systems treatment, offering numerous advantages scalability, compared traditional methods. These their unique characteristics effective delivery, represent significant advancement nanomedicine therapeutics. Further exploration manufacturing processes mechanisms could significantly advance natural medicine enhance efficacy exosome-based therapies.

Язык: Английский

Процитировано

8
Plant-Derived Extracellular Vesicles: Natural Nanocarriers for Biotechnological Drugs DOI Open Access
Eleonora Calzoni, Agnese Bertoldi, Gaia Cusumano

и другие.

Processes, Год журнала: 2024, Номер 12(12), С. 2938 - 2938

Опубликована: Дек. 23, 2024

Plant-derived extracellular vesicles (PDEVs) are lipid bilayer nanoparticles, naturally produced by plant cells, with sizes ranging from 50 to 500 nm. Recent studies have highlighted their great potential in the biotechnological and medical fields, due natural origin, high biocompatibility intrinsic therapeutic properties. PDEVs contain a complex biological cargo of proteins, lipids, nucleic acids secondary metabolites, including antioxidants anti-inflammatory molecules, making them ideal for biomedical applications such as drug delivery. These play key role intercellular communication gene regulation, proving be particularly promising personalized medicine. ability improve stability bioavailability, optimizing targeted release minimizing side effects. Despite some challenges, compositional variability need standardized protocols, at gunsight innovative research aimed improving loading capacity specificity. This review aims provide comprehensive overview PDEVs, exploring structure, isolation methods, functional characteristics, applications, highlighting advantages over synthetic nanoparticles animal-derived vesicles, leading an sustainable solution development new approaches.

Язык: Английский

Процитировано

7
Prospect of extracellular vesicles in tumor immunotherapy DOI Creative Commons

Wenbo Xia,

Yunhan Tan,

Y.-P. Liu

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Фев. 26, 2025

Extracellular vesicles (EVs), as cell-derived small vesicles, facilitate intercellular communication within the tumor microenvironment (TME) by transporting biomolecules. EVs from different sources have varied contents, demonstrating differentiated functions that can either promote or inhibit cancer progression. Thus, regulating formation, secretion, and intake of becomes a new strategy for intervention. Advancements in EV isolation techniques spurred interest EV-based therapies, particularly immunotherapy. This review explores multifaceted various immunotherapy, highlighting their potential vaccines adoptive cell therapy. Furthermore, we explore nanoparticle delivery systems Finally, discuss current state clinical settings future directions, aiming to provide crucial information advance development application treatment.

Язык: Английский

Процитировано

0