Frontiers in Bioengineering and Biotechnology,
Год журнала:
2024,
Номер
12
Опубликована: Дек. 11, 2024
Introduction
Alveolar
bone
defects
pose
significant
challenges
in
dentistry.
Due
to
the
complexity
of
alveolar
anatomy
and
insufficient
repair
mechanisms,
large
are
difficult
for
body
heal
naturally.
Clinical
treatment
typically
involves
use
substitute
materials.
However,
current
substitutes
often
suffer
from
limitations
such
as
osteoinductivity,
rapid
degradation,
inflammatory
responses,
poor
mechanical
properties.
Additionally,
irregular
morphology
complicates
application
solid
substitutes,
potentially
leading
secondary
damage
at
site.
Methods
To
address
these
challenges,
this
study
introduces
an
innovative
approach
by
integrating
MXene
nanomaterials
into
Ag-HA/GelMA
hydrogels
create
injectable
MXene/Ag-HA
composite
hydrogel.
renowned
their
excellent
biocompatibility,
antibacterial
properties,
strength.
Results
The
results
indicate
that
hydrogel
exhibits
satisfactory
biological
Specifically,
it
demonstrates
antibacterial,
antioxidant,
osteogenic
activities.
Gene
expression
analysis
further
reveals
promotes
osteogenesis
regulating
Dmp1
Dusp1.
Discussion
findings
suggest
is
a
promising
candidate
regeneration.
integration
enhances
its
making
well-suited
defects.
Furthermore,
underscores
vast
potential
biomedical
field,
hinting
applications
beyond
repair.
Cells,
Год журнала:
2025,
Номер
14(2), С. 145 - 145
Опубликована: Янв. 20, 2025
Maxillofacial
bone
defects
can
have
a
profound
impact
on
both
facial
function
and
aesthetics.
While
various
biomaterial
scaffolds
shown
promise
in
addressing
these
challenges,
regenerating
this
region
remains
complex
due
to
its
irregular
shape,
intricate
structure,
differing
cellular
origins
compared
other
bones
the
human
body.
Moreover,
significant
variable
mechanical
loads
placed
maxillofacial
add
further
complexity,
especially
cases
of
difficult-to-treat
medical
conditions.
This
review
provides
brief
overview
medication-related
osteonecrosis
jaw
(MRONJ),
highlighting
medication-induced
adverse
reactions
associated
clinical
challenges
treating
condition.
The
purpose
manuscript
is
emphasize
role
biotechnology
tissue
engineering
technologies
therapy.
By
using
scaffold
materials
biofactors
combination
with
autologous
cells,
innovative
solutions
are
explored
for
repair
damaged
bones.
ongoing
search
effective
that
address
improve
vitro
preparation
subsequent
regeneration
critical.
primary
spotlight
current
research
trends
novel
approaches
area.
Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials,
Год журнала:
2024,
Номер
163, С. 106848 - 106848
Journal of the American Ceramic Society,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 6, 2024
Abstract
The
increasing
demand
for
bone
grafts
due
to
the
aging
population
has
opened
new
opportunities
manufacture
of
porous
ceramics
assist
in
reconstruction.
In
our
study,
we
investigate
a
new,
promising
method
hierarchically
structures
straightforward
and
tunable
way.
It
consists
combining
novel
technology
capillary
suspensions,
formed
by
mixing
solid
particles
two
immiscible
liquids,
one
less
than
5
vol%,
with
freeze
casting.
We
have
successfully
achieved
alumina
beta‐tricalcium
phosphate
(β‐TCP)
materials
both
<2
µm
20–50
as
smallest
largest
pore
sizes,
respectively.
microstructure
exhibits
fully
open
pores
high
levels
porosity
(>60%).
suspensions’
rheological
behavior
indicates
that
silica
nano‐suspensions
secondary
fluid
creates
stronger
internal
particle
network
sucrose
system.
Conversely,
opposite
was
observed
β‐TCP
These
differences
were
attributed
change
affinity
between
fluids
loading.
systems
served
deepen
knowledge
about
area
suspensions
proved
their
use
hierarchical
scaffolds
tissue
engineering.
This
study
investigated
the
potential
use
of
a
3D-printed
β-tricalcium
phosphate
(β-TCP)
scaffold
as
bone-mimicking
environment
in
an
advanced
vitro
osteosarcoma
preclinical
model.
The
compatibility
with
cell
spheroids,
endothelial
cells,
and
primary
bone
marrow-derived
mesenchymal
stem
cells
(pBMSCs)
was
evaluated
along
its
physicochemical
characteristics.
Transcriptomic
analysis
pBMSCs
on
scaffolds
revealed
gene
expression
profiles,
indicating
pronounced
organisation
extracellular
matrix
minor
osteogenic
activity.
model
effectively
replicated
significant
aspects
tumour
microenvironment
tri-culture
system,
dynamic
perfusion
enhancing
metabolic
developed
scaffold-based
employed
doxorubicin
cytotoxicity
test.
physiological
significance
demonstrated
by
distinct
accumulation,
contrast
to
spheroid
monocultures.
Besides
limitations
proposed
approach
terms
efficient
vascularisation
model,
this
highlights
β-TCP
modelling
support
physiologically
relevant
models.
Journal of Clinical and Experimental Dentistry,
Год журнала:
2025,
Номер
unknown, С. e211 - e218
Опубликована: Янв. 1, 2025
Vertical
and
horizontal
bone
augmentation
is
one
of
the
most
challenging
techniques
in
engineering.
The
use
barrier
membranes
scaffolds
guided
regeneration
(GBR)
procedures
a
common
approach
for
treatment
lost
around
teeth
dental
implants.
aim
this
study
was
to
estimate
effects
synthetic
poly
(lactic
acid/caprolactone)
[P(LA/CL)]
bilayer
membrane
GBR,
compared
porcine
collagen
membrane,
vertical
model
on
10-12-months
old
rat
skull
without
periosteum.
hydroxyapatite
(HAp)
block
(diameter:
4
mm,
height:
3
porosity:75%,
average
pore
size:150
μm)
placed
P(LA/CL)
(solid
layer:
25
μm,
porous
175
or
layer,
layer)
applied
onto
HAp
block.
At
3,
6,
12
weeks
after
surgery,
incised
tissues
were
fixed,
decalcified,
stained
with
hematoxylin
eosin
histological
evaluation.
remained
until
could
achieve
inhibit
cellular
invasion
from
repositioned
soft
tissues.
Local
formation
occurred
interconnected
pores
at
6
weeks.
On
other
hand,
did
not
its
expansion
weeks,
absorbed
Histomorphometrically,
P(LA/CL)/HAp
occupied
8.3
%
10.0
%,
respectively,
while
formed
upper
half
area
collagen/HAp.
results
biomimetic
indicated
that
might
be
effective
GBR
as
an
occlusive
absorbable
membrane.
Key
words:Guided
(GBR),
bone,
augmentation,
absorbable,
collagen,
hy-droxyapatite;
P(LA/CL),
biomimetic.
