Frontiers in Bioengineering and Biotechnology,
Journal Year:
2024,
Volume and Issue:
12
Published: Dec. 11, 2024
Introduction
Alveolar
bone
defects
pose
significant
challenges
in
dentistry.
Due
to
the
complexity
of
alveolar
anatomy
and
insufficient
repair
mechanisms,
large
are
difficult
for
body
heal
naturally.
Clinical
treatment
typically
involves
use
substitute
materials.
However,
current
substitutes
often
suffer
from
limitations
such
as
osteoinductivity,
rapid
degradation,
inflammatory
responses,
poor
mechanical
properties.
Additionally,
irregular
morphology
complicates
application
solid
substitutes,
potentially
leading
secondary
damage
at
site.
Methods
To
address
these
challenges,
this
study
introduces
an
innovative
approach
by
integrating
MXene
nanomaterials
into
Ag-HA/GelMA
hydrogels
create
injectable
MXene/Ag-HA
composite
hydrogel.
renowned
their
excellent
biocompatibility,
antibacterial
properties,
strength.
Results
The
results
indicate
that
hydrogel
exhibits
satisfactory
biological
Specifically,
it
demonstrates
antibacterial,
antioxidant,
osteogenic
activities.
Gene
expression
analysis
further
reveals
promotes
osteogenesis
regulating
Dmp1
Dusp1.
Discussion
findings
suggest
is
a
promising
candidate
regeneration.
integration
enhances
its
making
well-suited
defects.
Furthermore,
underscores
vast
potential
biomedical
field,
hinting
applications
beyond
repair.
Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials,
Journal Year:
2024,
Volume and Issue:
163, P. 106848 - 106848
This
study
investigated
the
potential
use
of
a
3D-printed
β-tricalcium
phosphate
(β-TCP)
scaffold
as
bone-mimicking
environment
in
an
advanced
vitro
osteosarcoma
preclinical
model.
The
compatibility
with
cell
spheroids,
endothelial
cells,
and
primary
bone
marrow-derived
mesenchymal
stem
cells
(pBMSCs)
was
evaluated
along
its
physicochemical
characteristics.
Transcriptomic
analysis
pBMSCs
on
scaffolds
revealed
gene
expression
profiles,
indicating
pronounced
organisation
extracellular
matrix
minor
osteogenic
activity.
model
effectively
replicated
significant
aspects
tumour
microenvironment
tri-culture
system,
dynamic
perfusion
enhancing
metabolic
developed
scaffold-based
employed
doxorubicin
cytotoxicity
test.
physiological
significance
demonstrated
by
distinct
accumulation,
contrast
to
spheroid
monocultures.
Besides
limitations
proposed
approach
terms
efficient
vascularisation
model,
this
highlights
β-TCP
modelling
support
physiologically
relevant
models.
Cells,
Journal Year:
2025,
Volume and Issue:
14(2), P. 145 - 145
Published: Jan. 20, 2025
Maxillofacial
bone
defects
can
have
a
profound
impact
on
both
facial
function
and
aesthetics.
While
various
biomaterial
scaffolds
shown
promise
in
addressing
these
challenges,
regenerating
this
region
remains
complex
due
to
its
irregular
shape,
intricate
structure,
differing
cellular
origins
compared
other
bones
the
human
body.
Moreover,
significant
variable
mechanical
loads
placed
maxillofacial
add
further
complexity,
especially
cases
of
difficult-to-treat
medical
conditions.
This
review
provides
brief
overview
medication-related
osteonecrosis
jaw
(MRONJ),
highlighting
medication-induced
adverse
reactions
associated
clinical
challenges
treating
condition.
The
purpose
manuscript
is
emphasize
role
biotechnology
tissue
engineering
technologies
therapy.
By
using
scaffold
materials
biofactors
combination
with
autologous
cells,
innovative
solutions
are
explored
for
repair
damaged
bones.
ongoing
search
effective
that
address
improve
vitro
preparation
subsequent
regeneration
critical.
primary
spotlight
current
research
trends
novel
approaches
area.
Journal of Clinical and Experimental Dentistry,
Journal Year:
2025,
Volume and Issue:
unknown, P. e211 - e218
Published: Jan. 1, 2025
Vertical
and
horizontal
bone
augmentation
is
one
of
the
most
challenging
techniques
in
engineering.
The
use
barrier
membranes
scaffolds
guided
regeneration
(GBR)
procedures
a
common
approach
for
treatment
lost
around
teeth
dental
implants.
aim
this
study
was
to
estimate
effects
synthetic
poly
(lactic
acid/caprolactone)
[P(LA/CL)]
bilayer
membrane
GBR,
compared
porcine
collagen
membrane,
vertical
model
on
10-12-months
old
rat
skull
without
periosteum.
hydroxyapatite
(HAp)
block
(diameter:
4
mm,
height:
3
porosity:75%,
average
pore
size:150
μm)
placed
P(LA/CL)
(solid
layer:
25
μm,
porous
175
or
layer,
layer)
applied
onto
HAp
block.
At
3,
6,
12
weeks
after
surgery,
incised
tissues
were
fixed,
decalcified,
stained
with
hematoxylin
eosin
histological
evaluation.
remained
until
could
achieve
inhibit
cellular
invasion
from
repositioned
soft
tissues.
Local
formation
occurred
interconnected
pores
at
6
weeks.
On
other
hand,
did
not
its
expansion
weeks,
absorbed
Histomorphometrically,
P(LA/CL)/HAp
occupied
8.3
%
10.0
%,
respectively,
while
formed
upper
half
area
collagen/HAp.
results
biomimetic
indicated
that
might
be
effective
GBR
as
an
occlusive
absorbable
membrane.
Key
words:Guided
(GBR),
bone,
augmentation,
absorbable,
collagen,
hy-droxyapatite;
P(LA/CL),
biomimetic.
Nanomedicine,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 18
Published: Jan. 31, 2025
Advancements
in
tissue
regeneration,
particularly
bone
regeneration
is
key
area
of
research
due
to
potential
novel
therapeutic
approaches.
Efforts
reduce
reliance
on
autologous
and
allogeneic
grafts
have
led
the
development
biomaterials
that
promote
synchronized
controlled
healing.
However,
use
growth
factors
limited
by
their
short
half-life,
slow
penetration,
large
molecular
size
toxicity.
These
suggest
traditional
delivery
methods
may
be
inadequate
hence,
address
these
challenges,
new
strategies
are
being
explored.
approaches
include
bioactive
substances
within
advanced
systems
enable
precise
spatiotemporal
control.
Dual-release
composite
scaffolds
offer
a
promising
solution
reducing
need
for
multiple
surgical
interventions
simplifying
treatment
process.
allow
sustained
drug
release,
enhancing
repair
while
minimizing
drawbacks
conventional
methods.
This
review
explores
various
dual-drug
release
systems,
discussing
modes
action,
types
drugs
used
mechanisms
improve
regeneration.
Biofabrication,
Journal Year:
2025,
Volume and Issue:
17(2), P. 025028 - 025028
Published: March 5, 2025
Ultraviolet
photopolymerization
additive
manufacturing
has
been
used
to
fabricate
calcium
phosphate
(Ca-P)
ceramic
scaffolds
for
repairing
bone
defects,
but
it
is
still
a
challenge
3D
printed
Ca-P
simultaneously
enhance
the
mechanical
strength
and
osteoinductivity.
Here,
we
successfully
developed
high-performance
hydroxyapatite
(HA)
scaffold
containingin-situcarbon
graphene
oxide
(GO)
by
precisely
regulating
degreasing
sintering
atmosphere.
The
results
indicated
that
properties
of
HA
could
be
significantly
improved
amount
ofin-situcarbon.
containing
0.27
wt.%
carbon
achieved
maximum
compressive
12.5
MPa
with
porosity
approximately
70%.
RNA
transcriptome
sequencing
analysis
revealed
thatin-situcarbon
promote
osteogenic
differentiation
improving
oxygen
transport
promoting
expression
multiple
angiogenic
factors.
More
importantly,
in
absence
osteoinductive
agents,
thein-situcarbon
GO
synergistically
promoted
more
effective
mineralization,
demonstrating
enhanced
osteoinductivityin
vitro.In
rodent
model,
bioceramic
also
exhibited
osteogenesis
critical
defects.
Therefore,in-situcarbon
osteoinductivity
scaffolds,
effectively
achieving
substantial
endogenous
regeneration.
This
strategy
will
provide
simple
energy-efficient
approach
engineering
